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ENZYME entry: EC 1.14.14.90

Accepted Name
Isoflavone 2'-hydroxylase.
Alternative Name(s)
CYP Ge-3.
CYP81E1.
Isoflavone 2'-monooxygenase.
Reaction catalysed
An isoflavone + [reduced NADPH--hemoprotein reductase] + O(2) <=> a 2'-hydroxyisoflavone + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • Acts on daidzein, formononetin and genistein.
  • EC 1.14.14.89 has the same reaction but is more specific as it requires a 4'-methoxyisoflavone.
  • Formerly EC 1.14.13.89.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.90
EC2PDB1.14.14.90
ExplorEnz1.14.14.90
PRIAM enzyme-specific profiles1.14.14.90
KEGG Ligand Database for Enzyme Nomenclature1.14.14.90
IUBMB Enzyme Nomenclature1.14.14.90
IntEnz1.14.14.90
MEDLINEFind literature relating to 1.14.14.90
MetaCyc1.14.14.90
UniProtKB/Swiss-Prot
P93147, C81E1_GLYEC

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