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ENZYME entry: EC 1.14.14.90

Accepted Name
isoflavone 2'-hydroxylase.
Alternative Name(s)
CYP81E1.
CYP Ge-3.
isoflavone 2'-monooxygenase.
Reaction catalysed
a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • Acts on daidzein, formononetin and genistein.
  • EC 1.14.14.89 has the same reaction but is more specific as it requires a 4'-methoxyisoflavone.
  • Formerly EC 1.14.13.89.
Cross-references
BRENDA1.14.14.90
EC2PDB1.14.14.90
ExplorEnz1.14.14.90
PRIAM enzyme-specific profiles1.14.14.90
KEGG Ligand Database for Enzyme Nomenclature1.14.14.90
IUBMB Enzyme Nomenclature1.14.14.90
IntEnz1.14.14.90
MEDLINEFind literature relating to 1.14.14.90
MetaCyc1.14.14.90
Rhea expert-curated reactions1.14.14.90
UniProtKB/Swiss-Prot
P93147, C81E1_GLYEC

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