Expasy logo

ENZYME

ENZYME entry: EC 1.14.15.17

PURL: https://purl.expasy.org/enzyme/EC/1.14.15.17
Accepted Name
pheophorbide a oxygenase
Alternative Name(s)
PaO
PAO
pheide a monooxygenase
pheide a oxygenase
Reaction catalysed
pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = red chlorophyll catabolite + 2 oxidized [2Fe-2S]-[ferredoxin]
Comment(s)
  • This enzyme catalyzes a key reaction in chlorophyll degradation, which occurs during leaf senescence and fruit ripening in higher plants.
  • The enzyme from Arabidopsis contains a Rieske-type iron-sulfur cluster and requires reduced ferredoxin, which is generated either by NADPH through the pentose-phosphate pathway or by the action of photosystem I.
  • While still attached to this enzyme, the product is rapidly converted into primary fluorescent chlorophyll catabolite by the action of EC 1.3.7.12.
  • Pheophorbide b acts as an inhibitor.
  • In (18)O2 labeling experiments, only the aldehyde oxygen is labeled, suggesting that the other oxygen atom may originate from H2O.
  • Formerly EC 1.14.12.20.
Cross-references
BRENDA1.14.15.17
EC2PDB1.14.15.17
ExplorEnz1.14.15.17
KEGG Ligand Database for Enzyme Nomenclature1.14.15.17
IUBMB Enzyme Nomenclature1.14.15.17
MEDLINEFind literature relating to 1.14.15.17
MetaCyc1.14.15.17
Rhea expert-curated reactions1.14.15.17
UniProtKB/Swiss-Prot
Q9FYC2, PAO_ARATHQ0DV66, PAO_ORYSJ

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.15.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-