ENZYME entry: EC 1.14.15.26
Accepted Name |
Toluene methyl-monooxygenase.
|
Reaction catalysed |
- Toluene + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) <=> benzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
- p-xylene + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) <=> 4-methylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
- m-xylene + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) <=> 3-methylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
|
Comment(s) |
- The enzyme, characterized from several Pseudomonas strains, catalyzes
the first step in the degradation of toluenes and xylenes.
- It has a broad substrate specificity and is also active with
substituted compounds, such as chlorotoluenes.
- The electrons are provided by a reductase (EC 1.18.1.3) that
transfers electrons from NADH via FAD and an [2Fe-2S] cluster.
- The enzyme can also act on its products, producing gem-diols that
spontaneously dehydrate to form aldehydes.
|
Cross-references |
BRENDA | 1.14.15.26 |
EC2PDB | 1.14.15.26 |
ExplorEnz | 1.14.15.26 |
PRIAM enzyme-specific profiles | 1.14.15.26 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.15.26 |
IUBMB Enzyme Nomenclature | 1.14.15.26 |
IntEnz | 1.14.15.26 |
MEDLINE | Find literature relating to 1.14.15.26 |
MetaCyc | 1.14.15.26 |
Rhea expert-curated reactions | 1.14.15.26 |
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