ENZYME entry: EC 1.14.15.26
| Accepted Name |
|---|
| Toluene methyl-monooxygenase.
|
| Reaction catalysed |
|---|
- Toluene + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) <=> benzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
- p-xylene + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) <=> 4-methylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
- m-xylene + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) <=> 3-methylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
|
| Comment(s) |
|---|
- The enzyme, characterized from several Pseudomonas strains, catalyzes
the first step in the degradation of toluenes and xylenes.
- It has a broad substrate specificity and is also active with
substituted compounds, such as chlorotoluenes.
- The electrons are provided by a reductase (EC 1.18.1.3) that
transfers electrons from NADH via FAD and an [2Fe-2S] cluster.
- The enzyme can also act on its products, producing gem-diols that
spontaneously dehydrate to form aldehydes.
|
| Cross-references |
|---|
| BRENDA | 1.14.15.26 |
| EC2PDB | 1.14.15.26 |
| ExplorEnz | 1.14.15.26 |
| PRIAM enzyme-specific profiles | 1.14.15.26 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.15.26 |
| IUBMB Enzyme Nomenclature | 1.14.15.26 |
| IntEnz | 1.14.15.26 |
| MEDLINE | Find literature relating to 1.14.15.26 |
| MetaCyc | 1.14.15.26 |
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.15.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-