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ENZYME entry: EC 1.14.15.30

Accepted Name
3-ketosteroid 9alpha-monooxygenase
Alternative Name(s)
3-ketosteroid 9alpha-hydroxylase
Reaction catalysed
androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
Comment(s)
  • The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis.
  • It forms a two-component system with a ferredoxin reductase (KshB).
  • The enzyme contains a Rieske-type iron-sulfur center and non-heme iron.
  • The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.
  • Formerly EC 1.14.13.142.
Cross-references
BRENDA1.14.15.30
EC2PDB1.14.15.30
ExplorEnz1.14.15.30
PRIAM enzyme-specific profiles1.14.15.30
KEGG Ligand Database for Enzyme Nomenclature1.14.15.30
IUBMB Enzyme Nomenclature1.14.15.30
IntEnz1.14.15.30
MEDLINEFind literature relating to 1.14.15.30
MetaCyc1.14.15.30
Rhea expert-curated reactions1.14.15.30
UniProtKB/Swiss-Prot
F1CMX0, KSHA1_RHORHF1CMX8, KSHA3_RHORHB6V6V5, KSHA4_RHORH
F1CMY8, KSHA5_RHORHA0R4R3, KSHA_MYCS2P71875, KSHA_MYCTU
A0R525, KSHB_MYCS2P9WJ92, KSHB_MYCTOP9WJ93, KSHB_MYCTU
B6V6V6, KSHB_RHORH

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