ENZYME entry: EC 1.14.15.33
Accepted Name |
Pikromycin synthase.
|
Alternative Name(s) |
CYP107L1. |
Reaction catalysed |
- Narbomycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) <=> pikromycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
- Narbomycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) <=> neopikromycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
- Narbomycin + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H(+) + 2 O(2) <=> novapikromyin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O
- 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) <=> methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
- 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) <=> neomethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
- 10-deoxymethymycin + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H(+) + 2 O(2) <=> novamethymycin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O
|
Cofactor(s) |
Heme-thiolate.
|
Comment(s) |
- A cytochrome P450 (heme-thiolate) protein.
- Involved in the biosynthesis of a number of bacterial macrolide
antibiotics containing a desosamine glycoside unit.
- With narbomycin it hydroxylates at either C-12 to give pikromycin or
C-14 to give neopikromycin or both positions to give narvopikromycin.
- With 10-deoxymethymycin it hydroxylates at either C-10 to give
methymycin or C-12 to give neomethymycin or both positions to give
novamethymycin.
- Formerly EC 1.14.13.185.
|
Cross-references |
BRENDA | 1.14.15.33 |
EC2PDB | 1.14.15.33 |
ExplorEnz | 1.14.15.33 |
PRIAM enzyme-specific profiles | 1.14.15.33 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.15.33 |
IUBMB Enzyme Nomenclature | 1.14.15.33 |
IntEnz | 1.14.15.33 |
MEDLINE | Find literature relating to 1.14.15.33 |
MetaCyc | 1.14.15.33 |
UniProtKB/Swiss-Prot |
|
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