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ENZYME entry: EC 1.14.15.33

Accepted Name
Pikromycin synthase.
Alternative Name(s)
CYP107L1.
Reaction catalysed
  • Narbomycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) <=> pikromycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
  • Narbomycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) <=> neopikromycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
  • Narbomycin + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H(+) + 2 O(2) <=> novapikromyin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O
  • 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) <=> methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
  • 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) <=> neomethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
  • 10-deoxymethymycin + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H(+) + 2 O(2) <=> novamethymycin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit.
  • With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin.
  • With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin.
  • Formerly EC 1.14.13.185.
Cross-references
BRENDA1.14.15.33
EC2PDB1.14.15.33
ExplorEnz1.14.15.33
PRIAM enzyme-specific profiles1.14.15.33
KEGG Ligand Database for Enzyme Nomenclature1.14.15.33
IUBMB Enzyme Nomenclature1.14.15.33
IntEnz1.14.15.33
MEDLINEFind literature relating to 1.14.15.33
MetaCyc1.14.15.33
Rhea expert-curated reactions1.14.15.33
UniProtKB/Swiss-Prot
O87605, PIKC_STRVZ

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