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ENZYME entry: EC 1.14.15.36

Accepted Name
Sterol 14-alpha-demethylase (ferredoxin).
Alternative Name(s)
CYP51.
Reaction catalysed
A 14-alpha-methylsteroid + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H(+) + 3 O(2) <=> a Delta(14)-steroid + formate + 6 oxidized ferredoxin [iron-sulfur] cluster + 4 H(2)O
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in several bacterial species.
  • The enzyme, which is involved in sterol biosynthesis, catalyzes a hydroxylation and a reduction of the 14-alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond.
  • The enzyme from Methylococcus capsulatus is fused to the ferredoxin by an alanine-rich linker.
  • Cf. EC 1.14.14.154.
Cross-references
BRENDA1.14.15.36
EC2PDB1.14.15.36
ExplorEnz1.14.15.36
PRIAM enzyme-specific profiles1.14.15.36
KEGG Ligand Database for Enzyme Nomenclature1.14.15.36
IUBMB Enzyme Nomenclature1.14.15.36
IntEnz1.14.15.36
MEDLINEFind literature relating to 1.14.15.36
MetaCyc1.14.15.36

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