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ENZYME entry: EC

Accepted Name
luteothin monooxygenase.
Reaction catalysed
4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]
  • The enzyme, characterized from the bacterium Streptomyces thioluteus, is a bifunctional cytochrome P450 (heme-thiolate) protein that catalyzes both the hydroxylation of its substrate and formation of a furan ring, the final step in the biosynthesis of the antibiotic aureothin.
  • In the bacteria Streptomyces orinoci and Streptomyces spectabilis an orthologous enzyme catalyzes a similar reaction that forms spectinabilin.
PRIAM enzyme-specific profiles1.14.15.37
KEGG Ligand Database for Enzyme Nomenclature1.14.15.37
IUBMB Enzyme Nomenclature1.14.15.37
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.15.37

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.15.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-