ENZYME entry: EC 1.14.16.1
Accepted Name |
Phenylalanine 4-monooxygenase.
|
Alternative Name(s) |
PAH. |
Phenylalaninase. |
Phenylalanine 4-hydroxylase. |
Phenylalanine hydroxylase. |
Reaction catalysed |
L-phenylalanine + tetrahydrobiopterin + O(2) <=> L-tyrosine + 4a-hydroxytetrahydrobiopterin |
Cofactor(s) |
Fe cation.
|
Comment(s) |
- The reaction involves an arene oxide which rearranges to give the
phenolic hydroxy group.
- This results in the hydrogen at C-4 migrating to C-3 and in part
being retained, a process known as the NIH-shift.
- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-
dihydrobiopterin, both spontaneously and by the action of
EC 4.2.1.96.
- The 6,7-dihydrobiopterin can be enzymically reduced back to
tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the
more stable compound 7,8-dihydrobiopterin.
- Formerly EC 1.14.3.1 and EC 1.99.1.2.
|
Cross-references |
PROSITE | PDOC00316 |
BRENDA | 1.14.16.1 |
EC2PDB | 1.14.16.1 |
ExplorEnz | 1.14.16.1 |
PRIAM enzyme-specific profiles | 1.14.16.1 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.16.1 |
IUBMB Enzyme Nomenclature | 1.14.16.1 |
IntEnz | 1.14.16.1 |
MEDLINE | Find literature relating to 1.14.16.1 |
MetaCyc | 1.14.16.1 |
Rhea expert-curated reactions | 1.14.16.1 |
UniProtKB/Swiss-Prot |
Q2KIH7, PH4H_BOVIN; | P90925, PH4H_CAEEL; | Q9A7V7, PH4H_CAUVC; |
P30967, PH4H_CHRVO; | Q54XS1, PH4H_DICDI; | P17276, PH4H_DROME; |
P00439, PH4H_HUMAN; | P16331, PH4H_MOUSE; | P43334, PH4H_PSEAE; |
Q8XU39, PH4H_RALSO; | P04176, PH4H_RAT; | Q98D72, PH4H_RHILO; |
Q9KLB8, PH4H_VIBCH; |
|
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