Expasy logo

ENZYME

ENZYME entry: EC 1.14.16.4

PURL: https://purl.expasy.org/enzyme/EC/1.14.16.4
Accepted Name
tryptophan 5-monooxygenase
Alternative Name(s)
indoleacetic acid-5-hydroxylase
L-tryptophan hydroxylase
tryptophan 5-hydroxylase
tryptophan hydroxylase
Reaction catalysed
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
Comment(s)
  • Activated by phosphorylation, catalyzed by a Ca(2+)-activated protein kinase.
  • The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96.
  • The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
Cross-references
BRENDA1.14.16.4
EC2PDB1.14.16.4
ExplorEnz1.14.16.4
KEGG Ligand Database for Enzyme Nomenclature1.14.16.4
IUBMB Enzyme Nomenclature1.14.16.4
MEDLINEFind literature relating to 1.14.16.4
MetaCyc1.14.16.4
Rhea expert-curated reactions1.14.16.4
UniProtKB/Swiss-Prot
P90925, PH4H_CAEELQ54XS1, PH4H_DICDIP17276, PH4H_DROME
P70080, TPH1_CHICKP17752, TPH1_HUMANP17532, TPH1_MOUSE
P17290, TPH1_RABITP09810, TPH1_RATQ92142, TPH1_XENLA
Q0EAB8, TPH2_HORSEQ8IWU9, TPH2_HUMANQ2HZ26, TPH2_MACMU
Q8CGV2, TPH2_MOUSEQ8CGU9, TPH2_RAT

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.16.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-