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ENZYME entry: EC 1.14.18.12

Accepted Name
2-hydroxy fatty acid dioxygenase.
Reaction catalysed
A (2R)-2-hydroxy C(n)-fatty acid + O(2) <=> a C(n-1)-fatty acid + H(2)O + CO(2)
Comment(s)
  • Requires Fe(II).
  • The enzyme, characterized from yeast, is involved in phytosphingosine metabolism.
  • The reaction is mediated by iron(IV) peroxide and results in the release of a water molecule and a carbon dioxide molecule, shortening the substrate by a single carbon atom and forming an odd-numbered fatty acid.
  • Both oxygen atoms of the original carboxylate group are released - one as the leaving water molecule, the other as one of the oxygens of the carbon dioxide molecule.
  • The two oxygen atoms in the newly-formed carboxylate originate from the 2-hydroxy group and from molecular oxygen, respectively.
  • The other oxygen atom of the molecular oxygen is incorporated into the leaving CO(2) molecule.
  • The enzyme from the yeast Saccharomyces cerevisiae is active at least toward C(14) to C(26) 2-hydroxy fatty acids, but not against C(8) 2-hydroxy fatty acid.
Cross-references
BRENDA1.14.18.12
EC2PDB1.14.18.12
ExplorEnz1.14.18.12
PRIAM enzyme-specific profiles1.14.18.12
KEGG Ligand Database for Enzyme Nomenclature1.14.18.12
IUBMB Enzyme Nomenclature1.14.18.12
IntEnz1.14.18.12
MEDLINEFind literature relating to 1.14.18.12
MetaCyc1.14.18.12
Rhea expert-curated reactions1.14.18.12
UniProtKB/Swiss-Prot
O13737, MPO1_SCHPO;  P25338, MPO1_YEAST;  

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