ENZYME entry: EC 126.96.36.199
View entry in original ENZYME format
View entry in raw text format (no links)
|2-hydroxy fatty acid dioxygenase.
|A (2R)-2-hydroxy C(n)-fatty acid + O(2) <=> a C(n-1)-fatty acid + H(2)O + CO(2)|
- Requires Fe(II).
- The enzyme, characterized from yeast, is involved in phytosphingosine
- The reaction is mediated by iron(IV) peroxide and results in the
release of a water molecule and a carbon dioxide molecule, shortening
the substrate by a single carbon atom and forming an odd-numbered
- Both oxygen atoms of the original carboxylate group are released -
one as the leaving water molecule, the other as one of the oxygens of
the carbon dioxide molecule.
- The two oxygen atoms in the newly-formed carboxylate originate from
the 2-hydroxy group and from molecular oxygen, respectively.
- The other oxygen atom of the molecular oxygen is incorporated into
the leaving CO(2) molecule.
- The enzyme from the yeast Saccharomyces cerevisiae is active at least
toward C(14) to C(26) 2-hydroxy fatty acids, but not against C(8)
2-hydroxy fatty acid.
|PRIAM enzyme-specific profiles||188.8.131.52|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.206|
|IUBMB Enzyme Nomenclature||220.127.116.11|
|MEDLINE||Find literature relating to 18.104.22.168|
entries corresponding to 1.14.18.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-