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ENZYME

ENZYME entry: EC 1.14.18.5

PURL: https://purl.expasy.org/enzyme/EC/1.14.18.5
Accepted Name
sphingolipid C4-monooxygenase
Alternative Name(s)
sphinganine C4-monooxygenase
sphingolipid C4-hydroxylase
Reaction catalysed
a dihydroceramide + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O
Comment(s)
  • The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes.
  • Some enzymes are bifunctional and also catalyze EC 1.14.19.17.
  • Formerly EC 1.14.13.169.
Cross-references
BRENDA1.14.18.5
EC2PDB1.14.18.5
ExplorEnz1.14.18.5
KEGG Ligand Database for Enzyme Nomenclature1.14.18.5
IUBMB Enzyme Nomenclature1.14.18.5
MEDLINEFind literature relating to 1.14.18.5
MetaCyc1.14.18.5
Rhea expert-curated reactions1.14.18.5
UniProtKB/Swiss-Prot
Q0II71, DEGS2_BOVING5EC63, DEGS2_CAEELQ6QHC5, DEGS2_HUMAN
Q8R2F2, DEGS2_MOUSEQ564G3, DEGS2_RATQ8VYI1, SBH1_ARATH
Q9AST3, SBH2_ARATH

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