A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.19.17

Accepted Name
Sphingolipid 4-desaturase.
Alternative Name(s)
Dehydroceramide desaturase.
Reaction catalysed
A dihydroceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H(2)O
Comment(s)
  • The enzyme, which has been characterized from plants, fungi, and mammals, generates a trans double bond at position 4 of sphinganine bases in sphingolipids.
  • The preferred substrate is dihydroceramide, but the enzyme is also active with dihydroglucosylceramide.
  • Unlike EC 1.14.19.29, this enzyme does not contain an integral cytochrome b5 domain and requires an external cytochrome b5.
  • The product serves as an important signaling molecules in mammals and is required for spermatide differentiation.
Cross-references
BRENDA1.14.19.17
EC2PDB1.14.19.17
ExplorEnz1.14.19.17
PRIAM enzyme-specific profiles1.14.19.17
KEGG Ligand Database for Enzyme Nomenclature1.14.19.17
IUBMB Enzyme Nomenclature1.14.19.17
IntEnz1.14.19.17
MEDLINEFind literature relating to 1.14.19.17
MetaCyc1.14.19.17
UniProtKB/Swiss-Prot
Q3ZBY7, DEGS1_BOVIN;  O44186, DEGS1_CAEEL;  Q5F3C1, DEGS1_CHICK;  
O15121, DEGS1_HUMAN;  Q6UQ04, DEGS1_MICFO;  O09005, DEGS1_MOUSE;  
Q5RE51, DEGS1_PONAB;  Q5XIF5, DEGS1_RAT;  Q68FB8, DEGS1_XENTR;  
Q0II71, DEGS2_BOVIN;  G5EC63, DEGS2_CAEEL;  Q6QHC5, DEGS2_HUMAN;  
Q8R2F2, DEGS2_MOUSE;  Q564G3, DEGS2_RAT;  Q5AJX2, DEGS_CANAL;  
C4R613, DEGS_KOMPG;  O59715, DEGS_SCHPO;  Q9ZPH4, DES1L_ARATH;  
Q6H5U3, DES1L_ORYSJ;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.19.-
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