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ENZYME

ENZYME entry: EC 1.14.19.17

PURL: https://purl.expasy.org/enzyme/EC/1.14.19.17
Accepted Name
sphingolipid 4-desaturase
Alternative Name(s)
dehydroceramide desaturase
Reaction catalysed
an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O
Comment(s)
  • The enzyme, which has been characterized from plants, fungi, and mammals, generates a trans double bond at position 4 of sphinganine bases in sphingolipids.
  • The preferred substrate is dihydroceramide, but the enzyme is also active with dihydroglucosylceramide.
  • Unlike EC 1.14.19.29, this enzyme does not contain an integral cytochrome b5 domain and requires an external cytochrome b5.
  • The product serves as an important signaling molecules in mammals and is required for spermatide differentiation.
Cross-references
BRENDA1.14.19.17
EC2PDB1.14.19.17
ExplorEnz1.14.19.17
KEGG Ligand Database for Enzyme Nomenclature1.14.19.17
IUBMB Enzyme Nomenclature1.14.19.17
MEDLINEFind literature relating to 1.14.19.17
MetaCyc1.14.19.17
Rhea expert-curated reactions1.14.19.17
UniProtKB/Swiss-Prot
Q6UQ04, DEGS1_ALEFOQ3ZBY7, DEGS1_BOVINO44186, DEGS1_CAEEL
Q5F3C1, DEGS1_CHICKQ94515, DEGS1_DROMEO15121, DEGS1_HUMAN
O09005, DEGS1_MOUSEQ5RE51, DEGS1_PONABQ5XIF5, DEGS1_RAT
Q68FB8, DEGS1_XENTRQ0II71, DEGS2_BOVING5EC63, DEGS2_CAEEL
Q6QHC5, DEGS2_HUMANQ8R2F2, DEGS2_MOUSEQ564G3, DEGS2_RAT
Q5AJX2, DEGS_CANALC4R613, DEGS_KOMPGO59715, DEGS_SCHPO
Q9ZPH4, DES1L_ARATHQ6H5U3, DES1L_ORYSJ

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