Home  |  Contact

ENZYME entry: EC 1.14.18.8

Accepted Name
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase.
Alternative Name(s)
7-alpha-hydroxy-4-cholesten-3-one 12-alpha-monooxygenase.
CYP12.
HCO 12-alpha-hydroxylase.
Sterol 12-alpha-hydroxylase.
Reaction catalysed
7-alpha-hydroxycholest-4-en-3-one + 2 ferrocytochrome b5 + 2 H(+) + O(2) <=> 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + 2 ferricytochrome b5 + + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Requires EC 1.6.2.4 and cytochrome b5 for maximal activity.
  • Important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid.
  • Formerly EC 1.14.13.95.
Cross-references
PROSITEPDOC00081
BRENDA1.14.18.8
EC2PDB1.14.18.8
ExplorEnz1.14.18.8
PRIAM enzyme-specific profiles1.14.18.8
KEGG Ligand Database for Enzyme Nomenclature1.14.18.8
IUBMB Enzyme Nomenclature1.14.18.8
IntEnz1.14.18.8
MEDLINEFind literature relating to 1.14.18.8
MetaCyc1.14.18.8
UniProtKB/Swiss-Prot
Q9UNU6, CP8B1_HUMAN;  O88962, CP8B1_MOUSE;  O02766, CP8B1_RABIT;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.18.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-