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ENZYME entry: EC 1.14.14.139

Accepted Name
5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase.
Alternative Name(s)
5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-monooxygenase.
CYP8B1.
Sterol 12-alpha-hydroxylase.
Reaction catalysed
5-beta-cholestane-3-alpha,7-alpha-diol + [reduced NADPH--hemoprotein reductase] + O(2) <=> 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in mammals.
  • This is the key enzyme in the biosynthesis of the bile acid cholic acid (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoic acid).
  • The activity of this enzyme determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid.
  • The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent.
  • Formerly EC 1.14.13.96.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.139
EC2PDB1.14.14.139
ExplorEnz1.14.14.139
PRIAM enzyme-specific profiles1.14.14.139
KEGG Ligand Database for Enzyme Nomenclature1.14.14.139
IUBMB Enzyme Nomenclature1.14.14.139
IntEnz1.14.14.139
MEDLINEFind literature relating to 1.14.14.139
MetaCyc1.14.14.139
UniProtKB/Swiss-Prot
Q7YRB2, CP8B1_PIG

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