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ENZYME entry: EC 1.14.19.29

Accepted Name
sphingolipid 8-(E/Z)-desaturase.
Alternative Name(s)
8 fatty acid desaturase.
8-sphingolipid desaturase.
Reaction catalysed
  • an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O
  • an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O
Comment(s)
  • The enzymes from higher plants convert sphinganine, 4E-sphing-4-enine and phytosphinganine into E/Z-mixtures of Delta(8)-desaturated products displaying different proportions of geometrical isomers depending on plant species.
  • The nature of the actual desaturase substrate has not yet been studied experimentally.
  • The enzymes contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase.
  • The homologous enzymes from some yeasts and diatoms, EC 1.14.19.18, act on sphing-4-enine ceramides and produce only the trans isomer.
Cross-references
BRENDA1.14.19.29
EC2PDB1.14.19.29
ExplorEnz1.14.19.29
PRIAM enzyme-specific profiles1.14.19.29
KEGG Ligand Database for Enzyme Nomenclature1.14.19.29
IUBMB Enzyme Nomenclature1.14.19.29
IntEnz1.14.19.29
MEDLINEFind literature relating to 1.14.19.29
MetaCyc1.14.19.29
Rhea expert-curated reactions1.14.19.29
UniProtKB/Swiss-Prot
Q9ZRP7, SLD1_ARATH;  Q9FR82, SLD1_BOROF;  Q43469, SLD1_HELAN;  
Q3EBF7, SLD2_ARATH;  

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