ENZYME entry: EC 1.14.19.19

Accepted Name
Sphingolipid 10-desaturase.
Reaction catalysed
A (4E,8E)-sphinga-4,8-dienine ceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (4E,8E,10E)-sphinga-4,8,10-trienine ceramide + 2 ferricytochrome b5 + 2 H(2)O
Comment(s)
  • The enzyme, characterized from the marine diatom Thalassiosira pseudonana, produces an all-trans product.
  • Similar triunsaturated sphingoid bases are found in some marine invertebrates.
  • The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase.
Cross-references
BRENDA1.14.19.19
EC2PDB1.14.19.19
ExplorEnz1.14.19.19
PRIAM enzyme-specific profiles1.14.19.19
KEGG Ligand Database for Enzyme Nomenclature1.14.19.19
IUBMB Enzyme Nomenclature1.14.19.19
IntEnz1.14.19.19
MEDLINEFind literature relating to 1.14.19.19
MetaCyc1.14.19.19
UniProtKB/Swiss-Prot
Q4G2T3, DESAT_THAPS

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