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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Sphingolipid 10-desaturase.
Reaction catalysed
A (4E,8E)-sphinga-4,8-dienine ceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (4E,8E,10E)-sphinga-4,8,10-trienine ceramide + 2 ferricytochrome b5 + 2 H(2)O
  • The enzyme, characterized from the marine diatom Thalassiosira pseudonana, produces an all-trans product.
  • Similar triunsaturated sphingoid bases are found in some marine invertebrates.
  • The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase.
PRIAM enzyme-specific profiles1.14.19.19
KEGG Ligand Database for Enzyme Nomenclature1.14.19.19
IUBMB Enzyme Nomenclature1.14.19.19
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