Expasy logo

ENZYME

ENZYME entry: EC 1.14.19.19

Accepted Name
sphingolipid 10-desaturase
Reaction catalysed
a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine
Comment(s)
  • The enzyme, characterized from the marine diatom Thalassiosira pseudonana, produces an all-trans product.
  • Similar triunsaturated sphingoid bases are found in some marine invertebrates.
  • The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase.
Cross-references
BRENDA1.14.19.19
EC2PDB1.14.19.19
ExplorEnz1.14.19.19
PRIAM enzyme-specific profiles1.14.19.19
KEGG Ligand Database for Enzyme Nomenclature1.14.19.19
IUBMB Enzyme Nomenclature1.14.19.19
IntEnz1.14.19.19
MEDLINEFind literature relating to 1.14.19.19
MetaCyc1.14.19.19
Rhea expert-curated reactions1.14.19.19
UniProtKB/Swiss-Prot
Q4G2T3, DESAT_THAPS

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-