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ENZYME

ENZYME entry: EC 1.14.19.20

PURL: https://purl.expasy.org/enzyme/EC/1.14.19.20
Accepted Name
Delta(7)-sterol 5(6)-desaturase
Alternative Name(s)
5-DES
Delta(7)-sterol 5-desaturase
Delta(7)-sterol-C5(6)-desaturase
Delta(7)-sterol Delta(5)-dehydrogenase
lathosterol 5-desaturase
lathosterol oxidase
Reaction catalysed
a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O
Comment(s)
  • This enzyme, found in eukaryotic organisms, catalyzes the introduction of a double bond between the C5 and C6 carbons of the B ring of Delta(7)-sterols, to yield the corresponding Delta(5,7)- sterols.
  • The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively.
  • The enzyme is located at the endoplasmic reticulum and is membrane bound.
  • Formerly EC 1.3.3.2 and EC 1.14.21.6.
Cross-references
BRENDA1.14.19.20
EC2PDB1.14.19.20
ExplorEnz1.14.19.20
KEGG Ligand Database for Enzyme Nomenclature1.14.19.20
IUBMB Enzyme Nomenclature1.14.19.20
MEDLINEFind literature relating to 1.14.19.20
MetaCyc1.14.19.20
Rhea expert-curated reactions1.14.19.20
UniProtKB/Swiss-Prot
I1RFM2, ERG3A_GIBZEO94457, ERG3A_SCHPOA0A0E0SNE8, ERG3B_GIBZE
O13666, ERG3B_SCHPOQ59VG6, ERG3_CANALO93875, ERG3_CANAX
Q8NJ57, ERG3_CANDCP50860, ERG3_CANGAQ754B9, ERG3_EREGS
Q8J207, ERG3_LEPMCQ7SBB6, ERG3_NEUCRP32353, ERG3_YEAST
Q39208, SC5D1_ARATHQ9M883, SC5D2_ARATHO75845, SC5D_HUMAN
O88822, SC5D_MOUSEQ9EQS5, SC5D_RATQ9ZT29, SC5D_TOBAC

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