Home  |  Contact

ENZYME entry: EC 1.14.19.20

Accepted Name
Delta(7)-sterol 5(6)-desaturase.
Alternative Name(s)
5-DES.
Delta(7)-sterol 5-desaturase.
Delta(7)-sterol Delta(5)-dehydrogenase.
Delta(7)-sterol-C5(6)-desaturase.
Lathosterol 5-desaturase.
Lathosterol oxidase.
Reaction catalysed
A Delta(7)-sterol + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a Delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H(2)O
Comment(s)
  • This enzyme, found in eukaryotic organisms, catalyzes the introduction of a double bond between the C(5) and C(6) carbons of the B ring of Delta(7)-sterols, to yield the corresponding Delta(5,7)-sterols.
  • The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively.
  • The enzyme is located at the endoplasmic reticulum and is membrane bound.
  • Formerly EC 1.3.3.2 and EC 1.14.21.6.
Cross-references
BRENDA1.14.19.20
EC2PDB1.14.19.20
ExplorEnz1.14.19.20
PRIAM enzyme-specific profiles1.14.19.20
KEGG Ligand Database for Enzyme Nomenclature1.14.19.20
IUBMB Enzyme Nomenclature1.14.19.20
IntEnz1.14.19.20
MEDLINEFind literature relating to 1.14.19.20
MetaCyc1.14.19.20
UniProtKB/Swiss-Prot
O94457, ERG31_SCHPO;  O13666, ERG32_SCHPO;  Q754B9, ERG3_ASHGO;  
O93875, ERG3_CANAX;  Q8NJ57, ERG3_CANDC;  P50860, ERG3_CANGA;  
Q8J207, ERG3_LEPMC;  Q7SBB6, ERG3_NEUCR;  P32353, ERG3_YEAST;  
Q39208, SC5D1_ARATH;  Q9M883, SC5D2_ARATH;  O75845, SC5D_HUMAN;  
O88822, SC5D_MOUSE;  Q9EQS5, SC5D_RAT;  Q9ZT29, SC5D_TOBAC;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-