ENZYME entry: EC 1.14.19.22

PURL: https://purl.expasy.org/enzyme/EC/1.14.19.22

Accepted Name

acyl-lipid omega-6 desaturase (cytochrome b5)

Alternative Name(s)

linoleate synthase

oleate desaturase

oleoyl-CoA desaturase

phosphatidylcholine desaturase

Reaction catalysed

a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Comment(s)

This microsomal enzyme introduces a cis double bond in fatty acids attached to lipid molecules at a location 6 carbons away from the methyl end of the fatty acid.
The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond.
The most common substrates are oleoyl groups attached to either sn-1 or sn-2 position of the glycerol backbone in phosphatidylcholine. cf. EC 1.14.19.23.
Formerly EC 1.3.1.35.

Cross-references

BRENDA

1.14.19.22

EC2PDB

1.14.19.22

ExplorEnz

1.14.19.22

KEGG Ligand Database for Enzyme Nomenclature

1.14.19.22

IUBMB Enzyme Nomenclature

1.14.19.22

MEDLINE

Find literature relating to 1.14.19.22

MetaCyc

1.14.19.22

Rhea expert-curated reactions

1.14.19.22

UniProtKB/Swiss-Prot

P46313, FAD6E_ARATH

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