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ENZYME entry: EC

Accepted Name
Acyl-lipid omega-6 desaturase (cytochrome b5).
Alternative Name(s)
Linoleate synthase.
Oleate desaturase.
Oleoyl-CoA desaturase.
Phosphatidylcholine desaturase.
Reaction catalysed
An oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O
  • This microsomal enzyme introduces a cis double bond in fatty acids attached to lipid molecules at a location 6 carbons away from the methyl end of the fatty acid.
  • The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond.
  • The most common substrates are oleoyl groups attached to either sn-1 or sn-2 position of the glycerol backbone in phosphatidylcholine.
  • Cf. EC
  • Formerly EC
PRIAM enzyme-specific profiles1.14.19.22
KEGG Ligand Database for Enzyme Nomenclature1.14.19.22
IUBMB Enzyme Nomenclature1.14.19.22
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