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ENZYME entry: EC

Accepted Name
Sphingolipid 8-(E)-desaturase.
Alternative Name(s)
8 fatty acid desaturase.
8-sphingolipid desaturase.
Reaction catalysed
A (4E)-sphing-4-enine ceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (4E,8E)-sphing-4,8-dienine ceramide + 2 ferricytochrome b5 + 2 H(2)O
  • The enzyme, characterized from the yeasts Kluyveromyces lactis and Candida albicans and from the diatom Thalassiosira pseudonana, introduces a trans double bond at the 8-position of sphingoid bases in sphingolipids.
  • The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase.
  • The homologous enzymes from higher plants, EC, act on phytosphinganine (4-hydroxysphinganine) and produces a mixture of trans and cis isomers.
PRIAM enzyme-specific profiles1.14.19.18
KEGG Ligand Database for Enzyme Nomenclature1.14.19.18
IUBMB Enzyme Nomenclature1.14.19.18
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.19.18

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