A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_09. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Sphingolipid 8-(E)-desaturase.
Alternative Name(s)
8 fatty acid desaturase.
8-sphingolipid desaturase.
Reaction catalysed
A (4E)-sphing-4-enine ceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (4E,8E)-sphing-4,8-dienine ceramide + 2 ferricytochrome b5 + 2 H(2)O
  • The enzyme, characterized from the yeasts Kluyveromyces lactis and Candida albicans and from the diatom Thalassiosira pseudonana, introduces a trans double bond at the 8-position of sphingoid bases in sphingolipids.
  • The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase.
  • The homologous enzymes from higher plants, EC, act on phytosphinganine (4-hydroxysphinganine) and produces a mixture of trans and cis isomers.
PRIAM enzyme-specific profiles1.14.19.18
KEGG Ligand Database for Enzyme Nomenclature1.14.19.18
IUBMB Enzyme Nomenclature1.14.19.18
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-