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ENZYME

ENZYME entry: EC 1.14.19.30

Accepted Name
acyl-lipid (8-3)-desaturase
Alternative Name(s)
acyl-lipid 5-desaturase
Delta(5)-fatty-acid desaturase
Reaction catalysed
  • an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
  • an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
Comment(s)
  • The enzyme, which has been characterized from multiple organisms including the moss Physcomitrella patens, the marine microalga Rebecca salina, and the filamentous fungus Mortierella alpina, introduces a cis double bond at the 5-position in 20-carbon polyunsaturated fatty acids incorporated in a glycerolipid that contain a Delta(8) double bond.
  • The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
Cross-references
BRENDA1.14.19.30
EC2PDB1.14.19.30
ExplorEnz1.14.19.30
PRIAM enzyme-specific profiles1.14.19.30
KEGG Ligand Database for Enzyme Nomenclature1.14.19.30
IUBMB Enzyme Nomenclature1.14.19.30
IntEnz1.14.19.30
MEDLINEFind literature relating to 1.14.19.30
MetaCyc1.14.19.30
Rhea expert-curated reactions1.14.19.30
UniProtKB/Swiss-Prot
O74212, D5FAD_MORAPA9SIZ6, D5FAD_PHYPAA4KDP0, D5FAD_REBSA
Q8S3C1, D5FAD_THRSPO96099, FAD5B_DICDI

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