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ENZYME entry: EC 1.14.19.30

Accepted Name
Acyl-lipid (8-3)-desaturase.
Alternative Name(s)
Acyl-lipid 5-desaturase.
Delta(5)-fatty-acid desaturase.
Reaction catalysed
  • An (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O
  • An (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O
Comment(s)
  • The enzyme, which has been characterized from multiple organisms including the moss Physcomitrella patens, the marine microalga Rebecca salina, and the filamentous fungus Mortierella alpina, introduces a cis double bond at the 5-position in 20-carbon polyunsaturated fatty acids incorporated in a glycerolipid that contain a Delta(8) double bond.
  • The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
Cross-references
BRENDA1.14.19.30
EC2PDB1.14.19.30
ExplorEnz1.14.19.30
PRIAM enzyme-specific profiles1.14.19.30
KEGG Ligand Database for Enzyme Nomenclature1.14.19.30
IUBMB Enzyme Nomenclature1.14.19.30
IntEnz1.14.19.30
MEDLINEFind literature relating to 1.14.19.30
MetaCyc1.14.19.30
Rhea expert-curated reactions1.14.19.30
UniProtKB/Swiss-Prot
O74212, D5FAD_MORAP;  A9SIZ6, D5FAD_PHYPA;  A4KDP0, D5FAD_REBSA;  
Q8S3C1, D5FAD_THRSP;  O96099, FAD5B_DICDI;  

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