ENZYME entry: EC 1.14.19.37

Accepted Name
Acyl-CoA 5-desaturase.
Alternative Name(s)
Acyl-CoA 5-desaturase (non-methylene-interrupted).
Reaction catalysed
  • (11Z,14Z)-icosa-11,14-dienoyl-CoA + reduced acceptor + O(2) <=> (5Z,11Z,14Z)-icosa-5,11,14-trienoyl-CoA + acceptor + 2 H(2)O
  • (11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + reduced acceptor + O(2) <=> (5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoyl-CoA + acceptor + 2 H(2)O
Comment(s)
  • The enzyme, characterized from the plant Anemone leveillei, introduces a cis double bond at carbon 5 of acyl-CoAs that do not contain a double bond at position 8.
  • In vivo it forms non-methylene-interrupted polyunsaturated fatty acids such as sciadonate and juniperonate.
  • When expressed in Arabidopsis thaliana the enzyme could also act on unsaturated substrates such as palmitoyl-CoA.
  • Cf. EC 1.14.19.44.
Cross-references
BRENDA1.14.19.37
EC2PDB1.14.19.37
ExplorEnz1.14.19.37
PRIAM enzyme-specific profiles1.14.19.37
KEGG Ligand Database for Enzyme Nomenclature1.14.19.37
IUBMB Enzyme Nomenclature1.14.19.37
IntEnz1.14.19.37
MEDLINEFind literature relating to 1.14.19.37
MetaCyc1.14.19.37
UniProtKB/Swiss-Prot
P0DOW2, AL10_ANELE;  P0DOW3, AL21_ANELE;  

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