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ENZYME entry: EC 1.14.19.44

Accepted Name
Acyl-CoA (8-3)-desaturase.
Alternative Name(s)
Acyl-CoA 5-desaturase (methylene-interrupted).
Reaction catalysed
  • (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> arachidonoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O
  • (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O
Comment(s)
  • The enzyme introduces a cis double bond at carbon 5 of acyl-CoAs that contain a double bond at position 8.
  • The enzymes from algae, mosses, mammals and the protozoan Leishmania major catalyze the desaturation of dihomo-gamma-linoleate ((8Z,11Z,14Z)-icosa-8,11,14-trienoate) and (8Z,11Z,14Z,17Z)-icosa- 8,11,14,17-tetraenoate to generate arachidonate and (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate, respectively.
  • The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site and does not require an external cytochrome.
  • Cf. EC 1.14.19.37.
Cross-references
BRENDA1.14.19.44
EC2PDB1.14.19.44
ExplorEnz1.14.19.44
PRIAM enzyme-specific profiles1.14.19.44
KEGG Ligand Database for Enzyme Nomenclature1.14.19.44
IUBMB Enzyme Nomenclature1.14.19.44
IntEnz1.14.19.44
MEDLINEFind literature relating to 1.14.19.44
MetaCyc1.14.19.44
Rhea expert-curated reactions1.14.19.44
UniProtKB/Swiss-Prot
B2KKL4, FAD1_SIGCA;  D8X2C5, FAD2_SIGCA;  O60427, FADS1_HUMAN;  
Q920L1, FADS1_MOUSE;  A4UVI1, FADS1_PAPAN;  Q920R3, FADS1_RAT;  
Q9DEX7, FADS2_DANRE;  G5EG11, FAT4_CAEEL;  

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