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ENZYME entry: EC 1.14.19.38

Accepted Name
Acyl-lipid Delta(6)-acetylenase.
Reaction catalysed
  • A gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O
  • A stearidonoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O
Comment(s)
  • The enzyme, characterized from the moss Ceratodon purpureus, converts the double bond at position 6 of gamma-linolenate and stearidonate into a triple bond.
  • The product of the latter, dicranin, is the main fatty acid found in C.purpureus.
  • The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site.
  • The enzyme also has the activity of EC 1.14.19.47.
Cross-references
BRENDA1.14.19.38
EC2PDB1.14.19.38
ExplorEnz1.14.19.38
PRIAM enzyme-specific profiles1.14.19.38
KEGG Ligand Database for Enzyme Nomenclature1.14.19.38
IUBMB Enzyme Nomenclature1.14.19.38
IntEnz1.14.19.38
MEDLINEFind literature relating to 1.14.19.38
MetaCyc1.14.19.38
Rhea expert-curated reactions1.14.19.38
UniProtKB/Swiss-Prot
Q9LEN0, ACET6_CERPU

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