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ENZYME entry: EC 1.14.19.49

Accepted Name
tetracycline 7-halogenase.
Reaction catalysed
chloride + FADH2 + O2 + tetracycline <=> 7-chlorotetracycline + FAD + H(+) + 2 H2O
Comment(s)
  • Characterized from the bacterium Streptomyces aureofaciens.
  • The enzyme forms a lysine chloramine intermediate on an internal lysine residue before transferring the chlorine to the substrate.
  • It is stereo-selective for the 4S (natural) isomer of tetracycline.
  • FADH2 is provided by a dedicated EC 1.5.1.36.
Cross-references
BRENDA1.14.19.49
EC2PDB1.14.19.49
ExplorEnz1.14.19.49
PRIAM enzyme-specific profiles1.14.19.49
KEGG Ligand Database for Enzyme Nomenclature1.14.19.49
IUBMB Enzyme Nomenclature1.14.19.49
IntEnz1.14.19.49
MEDLINEFind literature relating to 1.14.19.49
MetaCyc1.14.19.49
Rhea expert-curated reactions1.14.19.49
UniProtKB/Swiss-Prot
A0A1E7MYN1, CTCP_KITAU

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