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ENZYME entry: EC 1.14.19.49
| Accepted Name |
|---|
| tetracycline 7-halogenase.
|
| Reaction catalysed |
|---|
| chloride + FADH2 + O2 + tetracycline <=> 7-chlorotetracycline + FAD + H(+) + 2 H2O |
| Comment(s) |
|---|
- Characterized from the bacterium Streptomyces aureofaciens.
- The enzyme forms a lysine chloramine intermediate on an internal
lysine residue before transferring the chlorine to the substrate.
- It is stereo-selective for the 4S (natural) isomer of tetracycline.
- FADH2 is provided by a dedicated EC 1.5.1.36.
|
| Cross-references |
|---|
| BRENDA | 1.14.19.49 |
| EC2PDB | 1.14.19.49 |
| ExplorEnz | 1.14.19.49 |
| PRIAM enzyme-specific profiles | 1.14.19.49 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.49 |
| IUBMB Enzyme Nomenclature | 1.14.19.49 |
| IntEnz | 1.14.19.49 |
| MEDLINE | Find literature relating to 1.14.19.49 |
| MetaCyc | 1.14.19.49 |
| Rhea expert-curated reactions | 1.14.19.49 |
| UniProtKB/Swiss-Prot |
|
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