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ENZYME entry: EC 1.14.19.49
Accepted Name |
tetracycline 7-halogenase.
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Reaction catalysed |
chloride + FADH2 + O2 + tetracycline <=> 7-chlorotetracycline + FAD + H(+) + 2 H2O |
Comment(s) |
- Characterized from the bacterium Streptomyces aureofaciens.
- The enzyme forms a lysine chloramine intermediate on an internal
lysine residue before transferring the chlorine to the substrate.
- It is stereo-selective for the 4S (natural) isomer of tetracycline.
- FADH2 is provided by a dedicated EC 1.5.1.36.
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Cross-references |
BRENDA | 1.14.19.49 |
EC2PDB | 1.14.19.49 |
ExplorEnz | 1.14.19.49 |
PRIAM enzyme-specific profiles | 1.14.19.49 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.49 |
IUBMB Enzyme Nomenclature | 1.14.19.49 |
IntEnz | 1.14.19.49 |
MEDLINE | Find literature relating to 1.14.19.49 |
MetaCyc | 1.14.19.49 |
Rhea expert-curated reactions | 1.14.19.49 |
UniProtKB/Swiss-Prot |
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