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ENZYME entry: EC 1.14.19.54

Accepted Name
1,2-dehydroreticuline synthase.
Alternative Name(s)
CYP82Y2.
Reaction catalysed
(S)-reticuline + [reduced NADPH--hemoprotein reductase] + O(2) <=> 1,2-dehydroreticuline + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The enzyme from Papaver rhoeas (field poppy) is specific for (S)- reticuline and does not act on the (R)-form.
  • The enzyme from Papaver somniferum (opium poppy), which is involved in the biosynthesis of morphine and related alkaloids, forms a fusion protein with EC 1.5.1.27, which catalyzes the reduction of 1,2- dehydroreticuline to (R)-reticuline, thus forming an epimerase system that converts (S)-reticuline to (R)-reticuline.
Cross-references
BRENDA1.14.19.54
EC2PDB1.14.19.54
ExplorEnz1.14.19.54
PRIAM enzyme-specific profiles1.14.19.54
KEGG Ligand Database for Enzyme Nomenclature1.14.19.54
IUBMB Enzyme Nomenclature1.14.19.54
IntEnz1.14.19.54
MEDLINEFind literature relating to 1.14.19.54
MetaCyc1.14.19.54
UniProtKB/Swiss-Prot
P0DKI7, STORR_PAPSO

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