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ENZYME entry: EC 1.14.19.55

Accepted Name
4-hydroxybenzoate brominase (decarboxylating).
Reaction catalysed
  • 4-hydroxybenzoate + 2 NADPH + 2 bromide + 2 O(2) + 2 H(+) <=> 2,4-dibromophenol + 2 NADP(+) + CO(2) + 4 H(2)O
  • 3,4-dihydroxybenzoate + 2 NADPH + 2 bromide + 2 O(2) + 2 H(+) <=> 3,5-dibromobenzene-1,2-diol + 2 NADP(+) + CO(2) + 4 H(2)O
Cofactor(s)
FAD.
Comment(s)
  • The enzyme, described from epiphytic marine bacteria of the genera Pseudoalteromonas and Marinomonas, is an unusual single-component FAD-dependent halogenase that contains a distinct NAD(P)H binding domain and does not require an additional flavin reductase for activity.
  • The enzyme catalyzes a bromination of its substrate, followed by a second bromination concurrent with decarboxylation.
Cross-references
BRENDA1.14.19.55
EC2PDB1.14.19.55
ExplorEnz1.14.19.55
PRIAM enzyme-specific profiles1.14.19.55
KEGG Ligand Database for Enzyme Nomenclature1.14.19.55
IUBMB Enzyme Nomenclature1.14.19.55
IntEnz1.14.19.55
MEDLINEFind literature relating to 1.14.19.55
MetaCyc1.14.19.55

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