ENZYME entry: EC 1.14.19.6
Accepted Name |
Acyl-CoA (9+3)-desaturase.
|
Alternative Name(s) |
Delta(12) desaturase. |
Delta(12) fatty acid desaturase. |
Delta(12)(omega(6))-desaturase. |
Delta(12)-fatty-acid desaturase. |
Oleoyl-CoA 12-desaturase. |
Oleoyl-CoA Delta(12) desaturase. |
Reaction catalysed |
- Oleoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> linoleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O
- Palmitoleoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> (9Z,12Z)-hexadeca-9,12-dienoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O
|
Comment(s) |
- This microsomal enzyme introduces a cis double bond at position 12 of
fatty-acyl-CoAs that contain a cis double bond at position 9.
- When acting on 19:1-Delta(10) fatty acyl-CoA the enzyme from the
pathogenic protozoan Trypanosoma brucei introduces the new double
bond at position 13, indicating that the new double bond is
introduced three carbons from the existing cis double bond, toward
the methyl-end of the fatty acid.
|
Cross-references |
PROSITE | PDOC00399 |
BRENDA | 1.14.19.6 |
EC2PDB | 1.14.19.6 |
ExplorEnz | 1.14.19.6 |
PRIAM enzyme-specific profiles | 1.14.19.6 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.6 |
IUBMB Enzyme Nomenclature | 1.14.19.6 |
IntEnz | 1.14.19.6 |
MEDLINE | Find literature relating to 1.14.19.6 |
MetaCyc | 1.14.19.6 |
Rhea expert-curated reactions | 1.14.19.6 |
UniProtKB/Swiss-Prot |
|
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