ENZYME

ENZYME entry: EC 1.14.19.6

Accepted Name

Acyl-CoA (9+3)-desaturase.

Alternative Name(s)

Delta(12) desaturase.

Delta(12) fatty acid desaturase.

Delta(12)(omega(6))-desaturase.

Delta(12)-fatty-acid desaturase.

Oleoyl-CoA 12-desaturase.

Oleoyl-CoA Delta(12) desaturase.

Reaction catalysed

Oleoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> linoleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O
Palmitoleoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> (9Z,12Z)-hexadeca-9,12-dienoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O

Comment(s)

This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9.
When acting on 19:1-Delta(10) fatty acyl-CoA the enzyme from the pathogenic protozoan Trypanosoma brucei introduces the new double bond at position 13, indicating that the new double bond is introduced three carbons from the existing cis double bond, toward the methyl-end of the fatty acid.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature