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ENZYME

ENZYME entry: EC 1.14.19.6

PURL: https://purl.expasy.org/enzyme/EC/1.14.19.6
Accepted Name
acyl-CoA (9+3)-desaturase
Alternative Name(s)
Delta(12)(omega(6))-desaturase
Delta(12) desaturase
Delta(12) fatty acid desaturase
Delta(12)-fatty-acid desaturase
oleoyl-CoA 12-desaturase
oleoyl-CoA Delta(12) desaturase
Reaction catalysed
  • (9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  • (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
Comment(s)
  • This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9.
  • When acting on 19:1Delta(10) fatty acyl-CoA the enzyme from the pathogenic protozoan Trypanosoma brucei introduces the new double bond at position 13, indicating that the new double bond is introduced three carbons from the existing cis double bond, toward the methyl-end of the fatty acid.
  • Formerly EC 1.14.19.n3.
Cross-references
BRENDA1.14.19.6
EC2PDB1.14.19.6
ExplorEnz1.14.19.6
KEGG Ligand Database for Enzyme Nomenclature1.14.19.6
IUBMB Enzyme Nomenclature1.14.19.6
MEDLINEFind literature relating to 1.14.19.6
MetaCyc1.14.19.6
Rhea expert-curated reactions1.14.19.6
UniProtKB/Swiss-Prot
B7SB91, FAD12_ACHDOQ9Y8H5, FAD12_MORAPP59668, FAD12_MORIS
B7SB92, FAD12_TRICAQ8GZC3, FAD2_VERFOP46313, FAD6E_ARATH
G5EGA5, FAT2_CAEEL

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