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ENZYME entry: EC 1.14.19.67

Accepted Name
Salutaridine synthase.
Alternative Name(s)
(R)-reticuline oxidase (C-C phenol-coupling).
Reaction catalysed
(R)-reticuline + [reduced NADPH--hemoprotein reductase] + O(2) <=> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product.
  • Formerly EC 1.1.3.35 and EC 1.14.21.4.
Cross-references
PROSITEPDOC00081
BRENDA1.14.19.67
EC2PDB1.14.19.67
ExplorEnz1.14.19.67
PRIAM enzyme-specific profiles1.14.19.67
KEGG Ligand Database for Enzyme Nomenclature1.14.19.67
IUBMB Enzyme Nomenclature1.14.19.67
IntEnz1.14.19.67
MEDLINEFind literature relating to 1.14.19.67
MetaCyc1.14.19.67
UniProtKB/Swiss-Prot
B1NF18, C719B_PAPSO

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