ENZYME entry: EC 1.14.19.68
Accepted Name |
(S)-canadine synthase.
|
Alternative Name(s) |
(S)-tetrahydroberberine synthase. |
(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming). |
CYP719A. |
Reaction catalysed |
(S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O(2) <=> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O |
Cofactor(s) |
Heme-thiolate.
|
Comment(s) |
- A cytochrome P450 (heme-thiolate) protein found in plants.
- The enzyme catalyzes an oxidative reaction that does not incorporate
oxygen into the product.
- Oxidation of the methoxyphenol group of the alkaloid
tetrahydrocolumbamine results in the formation of the methylenedioxy
bridge of canadine.
- Formerly EC 1.1.3.36 and EC 1.14.21.5.
|
Cross-references |
PROSITE | PDOC00081 |
BRENDA | 1.14.19.68 |
EC2PDB | 1.14.19.68 |
ExplorEnz | 1.14.19.68 |
PRIAM enzyme-specific profiles | 1.14.19.68 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.68 |
IUBMB Enzyme Nomenclature | 1.14.19.68 |
IntEnz | 1.14.19.68 |
MEDLINE | Find literature relating to 1.14.19.68 |
MetaCyc | 1.14.19.68 |
UniProtKB/Swiss-Prot |
|
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