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ENZYME

ENZYME entry: EC 1.14.19.68

Accepted Name
(S)-canadine synthase
Alternative Name(s)
(S)-tetrahydroberberine synthase
(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming)
CYP719A
Reaction catalysed
(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • The enzyme catalyzes an oxidative reaction that does not incorporate oxygen into the product.
  • Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine.
  • Formerly EC 1.1.3.36 and EC 1.14.21.5.
Cross-references
BRENDA1.14.19.68
EC2PDB1.14.19.68
ExplorEnz1.14.19.68
PRIAM enzyme-specific profiles1.14.19.68
KEGG Ligand Database for Enzyme Nomenclature1.14.19.68
IUBMB Enzyme Nomenclature1.14.19.68
IntEnz1.14.19.68
MEDLINEFind literature relating to 1.14.19.68
MetaCyc1.14.19.68
Rhea expert-curated reactions1.14.19.68
UniProtKB/Swiss-Prot
Q50LH4, C7193_ESCCAQ948Y1, C719A_COPJAB1NF19, C719D_ARGME
I3QBP4, C7A21_PAPSO

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