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ENZYME entry: EC 1.14.19.68

Accepted Name
(S)-canadine synthase.
Alternative Name(s)
(S)-tetrahydroberberine synthase.
(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming).
CYP719A.
Reaction catalysed
(S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O(2) <=> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • The enzyme catalyzes an oxidative reaction that does not incorporate oxygen into the product.
  • Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine.
  • Formerly EC 1.1.3.36 and EC 1.14.21.5.
Cross-references
PROSITEPDOC00081
BRENDA1.14.19.68
EC2PDB1.14.19.68
ExplorEnz1.14.19.68
PRIAM enzyme-specific profiles1.14.19.68
KEGG Ligand Database for Enzyme Nomenclature1.14.19.68
IUBMB Enzyme Nomenclature1.14.19.68
IntEnz1.14.19.68
MEDLINEFind literature relating to 1.14.19.68
MetaCyc1.14.19.68
Rhea expert-curated reactions1.14.19.68
UniProtKB/Swiss-Prot
Q50LH4, C7193_ESCCA;  Q948Y1, C719A_COPJA;  B1NF19, C719D_ARGME;  
I3QBP4, C7A21_PAPSO;  

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