Home  |  Contact

ENZYME entry: EC 1.14.19.72

Accepted Name
(-)-pluviatolide synthase.
Alternative Name(s)
CYP719A23.
Reaction catalysed
(-)-matairesinol + [reduced NADPH--hemoprotein reductase] + O(2) <=> (-)-pluviatolide + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • The enzyme from the plants Sinopodophyllum hexandrum and Podophyllum peltatum catalyzes the formation of a methylenedioxy-bridge.
  • It is involved in the biosynthesis of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
  • Formerly EC 1.14.21.11.
Cross-references
BRENDA1.14.19.72
EC2PDB1.14.19.72
ExplorEnz1.14.19.72
PRIAM enzyme-specific profiles1.14.19.72
KEGG Ligand Database for Enzyme Nomenclature1.14.19.72
IUBMB Enzyme Nomenclature1.14.19.72
IntEnz1.14.19.72
MEDLINEFind literature relating to 1.14.19.72
MetaCyc1.14.19.72
Rhea expert-curated reactions1.14.19.72
UniProtKB/Swiss-Prot
L7T720, C719A_PODPE;  L7T8H2, C719A_SINHE;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-