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ENZYME entry: EC 1.14.19.73

Accepted Name
(S)-nandinine synthase.
Alternative Name(s)
CYP719A3.
Reaction catalysed
(S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O(2) <=> (S)-nandinine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) enzyme found in plants.
  • The enzyme catalyzes an oxidative reaction that does not incorporate oxygen into the product.
  • Forms the methylenedioxy bridge of the protoberberine alkaloid (S)- nandinine by the oxidative ring closure of adjacent phenolic and methoxy groups of (S)-scoulerine.
  • Cf. EC 1.14.19.65, which catalyzes a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-cheilanthifoline.
  • Formerly EC 1.14.21.12.
Cross-references
BRENDA1.14.19.73
EC2PDB1.14.19.73
ExplorEnz1.14.19.73
PRIAM enzyme-specific profiles1.14.19.73
KEGG Ligand Database for Enzyme Nomenclature1.14.19.73
IUBMB Enzyme Nomenclature1.14.19.73
IntEnz1.14.19.73
MEDLINEFind literature relating to 1.14.19.73
MetaCyc1.14.19.73
UniProtKB/Swiss-Prot
Q50LH4, C7193_ESCCA;  B1NF19, C719D_ARGME;  

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