Expasy logo

ENZYME

ENZYME entry: EC 1.14.19.65

Accepted Name
(S)-cheilanthifoline synthase
Alternative Name(s)
(S)-scoulerine oxidase (methylenedioxy-bridge-forming)
CYP719A14
Reaction catalysed
(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein catalyzing an oxidative reaction that does not incorporate oxygen into the product.
  • Forms the methylenedioxy bridge of the protoberberine alkaloid cheilanthifoline by the oxidative ring closure of adjacent phenolic and methoxy groups of scoulerine. cf. EC 1.14.19.73 which catalyzes a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-nandinine.
  • Formerly EC 1.1.3.33 and EC 1.14.21.2.
Cross-references
BRENDA1.14.19.65
EC2PDB1.14.19.65
ExplorEnz1.14.19.65
PRIAM enzyme-specific profiles1.14.19.65
KEGG Ligand Database for Enzyme Nomenclature1.14.19.65
IUBMB Enzyme Nomenclature1.14.19.65
IntEnz1.14.19.65
MEDLINEFind literature relating to 1.14.19.65
MetaCyc1.14.19.65
Rhea expert-curated reactions1.14.19.65
UniProtKB/Swiss-Prot
B5UAQ8, C7195_ESCCAB1NF20, C719E_ARGME

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-