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ENZYME entry: EC 1.14.19.65

Accepted Name
(S)-cheilanthifoline synthase.
Alternative Name(s)
(S)-scoulerine oxidase (methylenedioxy-bridge-forming).
CYP719A14.
Reaction catalysed
(S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O(2) <=> (S)-cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein catalyzing an oxidative reaction that does not incorporate oxygen into the product.
  • Forms the methylenedioxy bridge of the protoberberine alkaloid cheilanthifoline by the oxidative ring closure of adjacent phenolic and methoxy groups of scoulerine.
  • Cf. EC 1.14.19.73 which catalyzes a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-nandinine.
  • Formerly EC 1.1.3.33 and EC 1.14.21.2.
Cross-references
BRENDA1.14.19.65
EC2PDB1.14.19.65
ExplorEnz1.14.19.65
PRIAM enzyme-specific profiles1.14.19.65
KEGG Ligand Database for Enzyme Nomenclature1.14.19.65
IUBMB Enzyme Nomenclature1.14.19.65
IntEnz1.14.19.65
MEDLINEFind literature relating to 1.14.19.65
MetaCyc1.14.19.65
UniProtKB/Swiss-Prot
B5UAQ8, C7195_ESCCA;  B1NF20, C719E_ARGME;  

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