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ENZYME

ENZYME entry: EC 1.14.19.80

PURL: https://purl.expasy.org/enzyme/EC/1.14.19.80
Accepted Name
(19E)-geissoschizine oxidase
Alternative Name(s)
CYP71D1V1
Reaction catalysed
(19E)-geissoschizine + reduced [NADPH--hemoprotein reductase] + O2 = akuammicine + formate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Comment(s)
  • A cytochrome P450 (heme-thiolate) enzyme characterized from the plant Catharanthus roseus (Madagascar periwinkle), that participates in the biosynthesis of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine.
  • The enzyme generates a nine-carbon ring that contains a nitrogen atom.
  • The direct product of the enzyme, 3,17-didehydrostemmadenine, is unstable, and in the absence of other enzymes becomes akuammicine non-enzymically.
  • However, in the presence of two dehydrogenases it is converted to stemmadenine via 17-dehydrostemmadenine.
Cross-references
BRENDA1.14.19.80
EC2PDB1.14.19.80
ExplorEnz1.14.19.80
KEGG Ligand Database for Enzyme Nomenclature1.14.19.80
IUBMB Enzyme Nomenclature1.14.19.80
MEDLINEFind literature relating to 1.14.19.80
MetaCyc1.14.19.80
Rhea expert-curated reactions1.14.19.80
UniProtKB/Swiss-Prot
A0A9E7S4M4, GO_ALSSCI1TEM0, GO_CATROP0DO79, GO_STRNX
P0DO88, GO_STRYXA0A9E7S4M3, RHS_ALSSC

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