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ENZYME

ENZYME entry: EC 1.14.19.81

PURL: https://purl.expasy.org/enzyme/EC/1.14.19.81
Accepted Name
polyneuridine aldehyde synthase
Alternative Name(s)
CYP71AY4
CYP71AY5
sarpagan bridge enzyme
Reaction catalysed
(19E)-geissoschizine + reduced [NADPH--hemoprotein reductase] + O2 = polyneuridine aldehyde + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Comment(s)
  • A heme-thiolate protein (P450).
  • The enzyme, characterized from the plants Rauwolfia serpentina (Indian snakeroot) and Gelsemium sempervirens (yellow jessamine), is involved in the biosynthesis of monoterpenoid indole alkaloids of the sarpagan, ajmalan and alstophyllan classes.
Cross-references
BRENDA1.14.19.81
EC2PDB1.14.19.81
ExplorEnz1.14.19.81
KEGG Ligand Database for Enzyme Nomenclature1.14.19.81
IUBMB Enzyme Nomenclature1.14.19.81
MEDLINEFind literature relating to 1.14.19.81
MetaCyc1.14.19.81
Rhea expert-curated reactions1.14.19.81
UniProtKB/Swiss-Prot
P0DO13, SBE1_RAUSEP0DO14, SBE_GELSE

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