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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Hapalindole-type alkaloid chlorinase.
Reaction catalysed
  • Hapalindole U + 2-oxoglutarate + O(2) + chloride <=> hapalindole G + succinate + CO(2) + H(2)O
  • 12-epi-fischerindole U + 2-oxoglutarate + O(2) + chloride <=> 12-epi-fischerindole G + succinate + CO(2) + H(2)O
The enzyme, characterized from hapalindole-type alkaloids-producing cyanobacteria, is a specialized iron(II)/2-oxoglutarate-dependent oxygenase that catalyzes the chlorination of its substrates in a reaction that requires oxygen, chloride ions, ferrous iron and 2-oxoglutarate.
PRIAM enzyme-specific profiles1.14.20.14
KEGG Ligand Database for Enzyme Nomenclature1.14.20.14
IUBMB Enzyme Nomenclature1.14.20.14
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