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ENZYME

ENZYME entry: EC 1.14.20.14

Accepted Name
hapalindole-type alkaloid chlorinase
Reaction catalysed
  • 2-oxoglutarate + chloride + H(+) + hapalindole U + O2 = CO2 + H2O + hapalindole G + succinate
  • 12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 = 12-epi-fischerindole G + CO2 + H2O + succinate
Comment(s)
The enzyme, characterized from hapalindole-type alkaloids-producing cyanobacteria, is a specialized iron(II)/2-oxoglutarate-dependent oxygenase that catalyzes the chlorination of its substrates in a reaction that requires oxygen, chloride ions, ferrous iron and 2-oxoglutarate.
Cross-references
BRENDA1.14.20.14
EC2PDB1.14.20.14
ExplorEnz1.14.20.14
PRIAM enzyme-specific profiles1.14.20.14
KEGG Ligand Database for Enzyme Nomenclature1.14.20.14
IUBMB Enzyme Nomenclature1.14.20.14
IntEnz1.14.20.14
MEDLINEFind literature relating to 1.14.20.14
MetaCyc1.14.20.14
Rhea expert-curated reactions1.14.20.14

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.20.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-