Home  |  Contact

ENZYME entry: EC 1.14.20.14

Accepted Name
Hapalindole-type alkaloid chlorinase.
Reaction catalysed
  • Hapalindole U + 2-oxoglutarate + O(2) + chloride <=> hapalindole G + succinate + CO(2) + H(2)O
  • 12-epi-fischerindole U + 2-oxoglutarate + O(2) + chloride <=> 12-epi-fischerindole G + succinate + CO(2) + H(2)O
Comment(s)
The enzyme, characterized from hapalindole-type alkaloids-producing cyanobacteria, is a specialized iron(II)/2-oxoglutarate-dependent oxygenase that catalyzes the chlorination of its substrates in a reaction that requires oxygen, chloride ions, ferrous iron and 2-oxoglutarate.
Cross-references
BRENDA1.14.20.14
EC2PDB1.14.20.14
ExplorEnz1.14.20.14
PRIAM enzyme-specific profiles1.14.20.14
KEGG Ligand Database for Enzyme Nomenclature1.14.20.14
IUBMB Enzyme Nomenclature1.14.20.14
IntEnz1.14.20.14
MEDLINEFind literature relating to 1.14.20.14
MetaCyc1.14.20.14
Rhea expert-curated reactions1.14.20.14

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.20.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-