ENZYME entry: EC 1.14.20.4
Accepted Name |
anthocyanidin synthase.
|
Alternative Name(s) |
leucoanthocyanidin dioxygenase. |
leucocyanidin oxygenase. |
Reaction catalysed |
2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate |
Comment(s) |
- Is involved in the pathway by which many flowering plants make
anthocyanin flower pigments (glycosylated anthocyandins).
- Hydroxylates the C-3 carbon, followed by a trans diaxial elimination,
forming a C-2,C-3 enol.
- The product loses a second water molecule to form anthocyanidins.
- When assayed in vitro, non-enzymic epimerization of the product can
lead to formation of dihydroflavanols.
- Thus when the substrate is leucocyanidin, a mixture of (+)-taxifolin
and (+)-epitaxifolin are formed.
- The enzyme can also oxidize the formed (+)-taxifolin to quercetin
(cf. EC 1.14.20.6).
- Formerly EC 1.14.11.19.
|
Cross-references |
BRENDA | 1.14.20.4 |
EC2PDB | 1.14.20.4 |
ExplorEnz | 1.14.20.4 |
PRIAM enzyme-specific profiles | 1.14.20.4 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.20.4 |
IUBMB Enzyme Nomenclature | 1.14.20.4 |
IntEnz | 1.14.20.4 |
MEDLINE | Find literature relating to 1.14.20.4 |
MetaCyc | 1.14.20.4 |
Rhea expert-curated reactions | 1.14.20.4 |
UniProtKB/Swiss-Prot |
A2WQ39, ANS1_ORYSI; | Q93VC3, ANS1_ORYSJ; | Q67VR7, ANS2_ORYSJ; |
A0A2R6PI27, LDOX_ACTCC; | Q96323, LDOX_ARATH; | P41213, LDOX_MAIZE; |
P51091, LDOX_MALDO; | O04274, LDOX_PERFR; | P51092, LDOX_PETHY; |
P51093, LDOX_VITVI; |
|
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