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ENZYME entry: EC 1.14.99.51

Accepted Name
Hercynylcysteine S-oxide synthase.
Reaction catalysed
Hercynine + L-cysteine + O(2) <=> S-hercyn-2-yl-L-cysteine S-oxide + H(2)O
Cofactor(s)
Fe(2+).
Comment(s)
  • The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44.
  • It is part of the biosynthesis pathway of ergothioneine.
  • The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine.
Cross-references
BRENDA1.14.99.51
EC2PDB1.14.99.51
ExplorEnz1.14.99.51
PRIAM enzyme-specific profiles1.14.99.51
KEGG Ligand Database for Enzyme Nomenclature1.14.99.51
IUBMB Enzyme Nomenclature1.14.99.51
IntEnz1.14.99.51
MEDLINEFind literature relating to 1.14.99.51
MetaCyc1.14.99.51
Rhea expert-curated reactions1.14.99.51
UniProtKB/Swiss-Prot
Q7RX33, EGT1_NEUCR;  O94632, EGT1_SCHPO;  

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