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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.99.54

Accepted Name
Lytic cellulose monooxygenase (C1-hydroxylating).
Alternative Name(s)
LPMO.
Lytic polysaccharide monooxygenase.
Reaction catalysed
((1->4)-beta-D-glucosyl)(n+m) + reduced acceptor + O(2) <=> ((1->4)-beta-D-glucosyl)(m-1)-(1->4)-D-glucono-1,5-lactone + ((1->4)-beta-D-glucosyl)(n) + acceptor + H(2)O
Cofactor(s)
Cu(+).
Comment(s)
  • This enzyme, found in fungi and bacteria, cleaves cellulose in an oxidative manner.
  • The cellulose fragments that are formed contain a D-glucono-1,5- lactone residue at the reducing end, which hydrolyzes quickly and spontaneously to the aldonic acid.
  • The electrons are provided in vivo by the cytochrome b domain of EC 1.1.99.18.
  • Ascorbate can serve as the electron donor in vitro.
Cross-references
BRENDA1.14.99.54
EC2PDB1.14.99.54
ExplorEnz1.14.99.54
PRIAM enzyme-specific profiles1.14.99.54
KEGG Ligand Database for Enzyme Nomenclature1.14.99.54
IUBMB Enzyme Nomenclature1.14.99.54
IntEnz1.14.99.54
MEDLINEFind literature relating to 1.14.99.54
MetaCyc1.14.99.54
UniProtKB/Swiss-Prot
A3KKC4, LCEMO_STRA7

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.99.-
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