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ENZYME

ENZYME entry: EC 1.14.99.54

PURL: https://purl.expasy.org/enzyme/EC/1.14.99.54
Accepted Name
lytic cellulose monooxygenase (C1-hydroxylating)
Alternative Name(s)
LPMO
lytic polysaccharide monooxygenase
Reaction catalysed
[(1->4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = [(1->4)-beta-D-glucosyl]m-1-(1->4)-D-glucono-1,5-lactone + [(1->4)-beta-D-glucosyl]n + acceptor + H2O
Comment(s)
  • This enzyme, found in fungi and bacteria, cleaves cellulose in an oxidative manner.
  • The cellulose fragments that are formed contain a D-glucono-1,5- lactone residue at the reducing end, which hydrolyzes quickly and spontaneously to the aldonic acid.
  • The electrons are provided in vivo by the cytochrome b domain of EC 1.1.99.18.
  • Ascorbate can serve as the electron donor in vitro.
Cross-references
Rhea expert-curated reactions1.14.99.54
ExplorEnz1.14.99.54
IUBMB Enzyme Nomenclature1.14.99.54
UniProtKB/Swiss-Prot
A3KKC4, LCEMO_STRA7A0A384K4U6, LP9A_BOTFBA0A0J9XKT0, LP9A_GEOCN
I1REU9, LP9A_GIBZES7Q0E7, LP9A_GLOTAA0A1C9ZP88, LP9A_GLOTR
A0A5J6BJT3, LP9A_MALCIB2B629, LP9A_PODANA0A478ECY3, LP9A_TALPI
A0A482A9N4, LP9A_TALVEG3XAP7, LP9A_THEAUG2QNT0, LP9A_THET4
A0A0H4K9X4, LP9A_THETOG2R6N0, LP9A_THETTG0R6T8, LP9A_TRIR6
O14405, LP9A_TRIRFQ4WP32, LP9B_ASPFUA0A5N6UX39, LP9B_ASPTM
A0A384JJE6, LP9B_BOTFBA0A0J9XL55, LP9B_GEOCNS7RK00, LP9B_GLOTA
A0A5J6BJT1, LP9B_MALCIB2AVF1, LP9B_PODANG2QCJ3, LP9B_THET4
A0A1C9CXI1, LP9B_THETOG2RB73, LP9B_THETTQ7Z9M7, LP9B_TRIR6
A0A5N6V3W5, LP9C_ASPTMA0A384JJB6, LP9C_BOTFBQ5AZ52, LP9C_EMENI
A0A0J9XK58, LP9C_GEOCNS7QKE2, LP9C_GLOTAA0A1C9ZMC3, LP9C_GLOTR
A0A4P8PKE4, LP9C_MALCIB2AUV0, LP9C_PODANA0A5N6UUF2, LP9D_ASPTM
A0A384JLD1, LP9D_BOTFBQ5B8T4, LP9D_EMENIA0A0J9XBC9, LP9D_GEOCN
S7QP81, LP9D_GLOTAA0A5J6BJN5, LP9D_MALCIB2ARG6, LP9D_PODAN
A0A5N6UNY1, LP9E_ASPTMA0A384JDH0, LP9E_BOTFBQ5AQA6, LP9E_EMENI
A0A5J6BJT0, LP9E_MALCIG2RGE5, LP9E_THETTA0A5N6UWA3, LP9F_ASPTM
A0A384JXL6, LP9F_BOTFBQ5B6H0, LP9F_EMENIA0A5J6BJN2, LP9F_MALCI
Q1K4Q1, LP9F_NEUCRB2B403, LP9F_PODANA0A5N6UV50, LP9G_ASPTM
A0A384JTK5, LP9G_BOTFBC8V530, LP9G_EMENIA0A5J6BJP2, LP9G_MALCI
B2B5J7, LP9G_PODANG2QZK6, LP9G_THETTA0A384JZ02, LP9H_BOTFB
Q5BEI9, LP9H_EMENIB2ADG1, LP9H_PODANG2Q9T3, LP9H_THET4
A0A384J8V9, LP9I_BOTFBC8V4I9, LP9I_EMENIG2RGE6, LP9T_THETT
G2RB72, LP9U_THETTA8NCG7, LP9_COPC7A0A1Y2IY60, LP9_TRAC3
BRENDA1.14.99.54
MetaCyc1.14.99.54
KEGG Ligand Database for Enzyme Nomenclature1.14.99.54
MEDLINEFind literature relating to 1.14.99.54

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