ENZYME entry: EC 1.14.99.54

Accepted Name

lytic cellulose monooxygenase (C1-hydroxylating)

Alternative Name(s)

LPMO

lytic polysaccharide monooxygenase

Reaction catalysed

[(1->4)-beta-D-glucosyl]n+m + reduced acceptor + O2 <=> [(1->4)-beta-D-glucosyl]m-1-(1->4)-D-glucono-1,5-lactone + [(1->4)-beta-D-glucosyl]n + acceptor + H2O

Comment(s)

This enzyme, found in fungi and bacteria, cleaves cellulose in an oxidative manner.
The cellulose fragments that are formed contain a D-glucono-1,5- lactone residue at the reducing end, which hydrolyzes quickly and spontaneously to the aldonic acid.
The electrons are provided in vivo by the cytochrome b domain of EC 1.1.99.18.
Ascorbate can serve as the electron donor in vitro.

Cross-references

BRENDA

1.14.99.54

EC2PDB

1.14.99.54

ExplorEnz

1.14.99.54

PRIAM enzyme-specific profiles

1.14.99.54

KEGG Ligand Database for Enzyme Nomenclature

1.14.99.54

IUBMB Enzyme Nomenclature

1.14.99.54

IntEnz

1.14.99.54

MEDLINE

Find literature relating to 1.14.99.54

MetaCyc

1.14.99.54

Rhea expert-curated reactions

1.14.99.54

UniProtKB/Swiss-Prot

A3KKC4, LCEMO_STRA7

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