ENZYME entry: EC 1.14.99.58
Accepted Name |
Heme oxygenase (biliverdin-IX-beta and delta-forming).
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Reaction catalysed |
- Protoheme + 3 reduced acceptor + 3 O(2) <=> biliverdin-IX-delta + CO + Fe(2+) + 3 acceptor + 3 H(2)O
- Protoheme + 3 reduced acceptor + 3 O(2) <=> biliverdin-IX-beta + CO + Fe(2+) + 3 acceptor + 3 H(2)O
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Comment(s) |
- The enzyme, characterized from the bacterium Pseudomonas aeruginosa,
differs from EC 1.14.15.20 in that the heme substrate is rotated by
approximately 110 degrees within the active site, resulting in
cleavage at a different part of the ring.
- It forms a mixture of about 70% biliverdin-IX-delta and 30%
biliverdin-IX-beta.
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Cross-references |
BRENDA | 1.14.99.58 |
EC2PDB | 1.14.99.58 |
ExplorEnz | 1.14.99.58 |
PRIAM enzyme-specific profiles | 1.14.99.58 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.99.58 |
IUBMB Enzyme Nomenclature | 1.14.99.58 |
IntEnz | 1.14.99.58 |
MEDLINE | Find literature relating to 1.14.99.58 |
MetaCyc | 1.14.99.58 |
Rhea expert-curated reactions | 1.14.99.58 |
UniProtKB/Swiss-Prot |
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