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ENZYME entry: EC 1.14.99.58

Accepted Name
Heme oxygenase (biliverdin-IX-beta and delta-forming).
Reaction catalysed
  • Protoheme + 3 reduced acceptor + 3 O(2) <=> biliverdin-IX-delta + CO + Fe(2+) + 3 acceptor + 3 H(2)O
  • Protoheme + 3 reduced acceptor + 3 O(2) <=> biliverdin-IX-beta + CO + Fe(2+) + 3 acceptor + 3 H(2)O
Comment(s)
  • The enzyme, characterized from the bacterium Pseudomonas aeruginosa, differs from EC 1.14.15.20 in that the heme substrate is rotated by approximately 110 degrees within the active site, resulting in cleavage at a different part of the ring.
  • It forms a mixture of about 70% biliverdin-IX-delta and 30% biliverdin-IX-beta.
Cross-references
BRENDA1.14.99.58
EC2PDB1.14.99.58
ExplorEnz1.14.99.58
PRIAM enzyme-specific profiles1.14.99.58
KEGG Ligand Database for Enzyme Nomenclature1.14.99.58
IUBMB Enzyme Nomenclature1.14.99.58
IntEnz1.14.99.58
MEDLINEFind literature relating to 1.14.99.58
MetaCyc1.14.99.58
Rhea expert-curated reactions1.14.99.58
UniProtKB/Swiss-Prot
Q9KL41, HUTZ_VIBCH;  G3XCZ8, PIGA_PSEAE;  

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