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ENZYME entry: EC 1.14.99.69

Accepted Name
tRNA 2-(methylsulfanyl)-N(6)-isopentenyladenosine(37) hydroxylase.
Alternative Name(s)
tRNA 2-(methylsulfanyl)-N(6)-dimethylallyladenosine(37) hydroxylase.
tRNA 2-methylthio-N(6)-isopentenyl adenosine(37) hydroxylase.
Reaction catalysed
N(6)-(3-methylbut-2-en-1-yl)-2-(methylsulfanyl)adenosine(37) in tRNA + reduced acceptor + O(2) <=> N(6)-((2E)-4-hydroxy-3-methylbut-2-en-1-yl)-2-(methylsulfanyl)adenosine(37) in tRNA + acceptor + H(2)O
Comment(s)
  • The enzyme, found only within a small subset of facultative anaerobic bacteria, belongs to the nonheme diiron family.
  • The enzyme from Salmonella typhimurium was shown to catalyze a stereoselective (E) hydroxylation at the terminal C(4)-position of the dimethylallyl group.
Cross-references
BRENDA1.14.99.69
EC2PDB1.14.99.69
ExplorEnz1.14.99.69
PRIAM enzyme-specific profiles1.14.99.69
KEGG Ligand Database for Enzyme Nomenclature1.14.99.69
IUBMB Enzyme Nomenclature1.14.99.69
IntEnz1.14.99.69
MEDLINEFind literature relating to 1.14.99.69
MetaCyc1.14.99.69
Rhea expert-curated reactions1.14.99.69

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