Home  |  Contact

ENZYME entry: EC 1.16.1.6

Accepted Name
Cyanocobalamin reductase (cyanide-eliminating).
Alternative Name(s)
Cyanocobalamin reductase.
Cyanocobalamin reductase (NADPH, cyanide-eliminating).
Cyanocobalamin reductase (NADPH; CN-eliminating).
NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating).
Reaction catalysed
2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) <=> 2 cyanocob(III)alamin + 2 [cyanocobalamin reductase] + NADPH
Cofactor(s)
Flavoprotein.
Comment(s)
  • The mammalian enzyme, which is cytosolic, can bind internalized cyanocobalamin and process it to cob(II)alamin by removing the upper axial ligand.
  • The product remains bound to the protein, which, together with its interacting partner MMADHC, transfers it directly to downstream enzymes involved in adenosylcobalamin and methylcobalamin biosynthesis.
  • In addition to its decyanase function, the mammalian enzyme also catalyzes an entirely different chemical reaction with alkylcobalamins, using the thiolate of glutathione for nucleophilic displacement, generating cob(I)alamin and the corresponding glutathione thioether (cf. EC 2.5.1.151).
  • Formerly EC 1.6.99.12.
Cross-references
BRENDA1.16.1.6
EC2PDB1.16.1.6
ExplorEnz1.16.1.6
PRIAM enzyme-specific profiles1.16.1.6
KEGG Ligand Database for Enzyme Nomenclature1.16.1.6
IUBMB Enzyme Nomenclature1.16.1.6
IntEnz1.16.1.6
MEDLINEFind literature relating to 1.16.1.6
MetaCyc1.16.1.6
UniProtKB/Swiss-Prot
Q5E9C8, MMAC_BOVIN;  Q5ZL21, MMAC_CHICK;  Q5RFU5, MMAC_DANRE;  
Q9Y4U1, MMAC_HUMAN;  Q9CZD0, MMAC_MOUSE;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.16.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.16.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-