ENZYME entry: EC 1.16.1.6
| Accepted Name |
|---|
| Cyanocobalamin reductase (cyanide-eliminating).
|
| Alternative Name(s) |
|---|
| Cyanocobalamin reductase. |
| Cyanocobalamin reductase (NADPH, cyanide-eliminating). |
| Cyanocobalamin reductase (NADPH; CN-eliminating). |
| NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating). |
| Reaction catalysed |
|---|
| 2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) <=> 2 cyanocob(III)alamin + 2 [cyanocobalamin reductase] + NADPH |
| Cofactor(s) |
|---|
| Flavoprotein.
|
| Comment(s) |
|---|
- The mammalian enzyme, which is cytosolic, can bind internalized
cyanocobalamin and process it to cob(II)alamin by removing the upper
axial ligand.
- The product remains bound to the protein, which, together with its
interacting partner MMADHC, transfers it directly to downstream
enzymes involved in adenosylcobalamin and methylcobalamin
biosynthesis.
- In addition to its decyanase function, the mammalian enzyme also
catalyzes an entirely different chemical reaction with
alkylcobalamins, using the thiolate of glutathione for nucleophilic
displacement, generating cob(I)alamin and the corresponding
glutathione thioether (cf. EC 2.5.1.151).
- Formerly EC 1.6.99.12.
|
| Cross-references |
|---|
| BRENDA | 1.16.1.6 |
| EC2PDB | 1.16.1.6 |
| ExplorEnz | 1.16.1.6 |
| PRIAM enzyme-specific profiles | 1.16.1.6 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.16.1.6 |
| IUBMB Enzyme Nomenclature | 1.16.1.6 |
| IntEnz | 1.16.1.6 |
| MEDLINE | Find literature relating to 1.16.1.6 |
| MetaCyc | 1.16.1.6 |
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