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ENZYME entry: EC 2.5.1.151

Accepted Name
alkylcobalamin dealkylase.
Alternative Name(s)
alkylcobalamin reductase.
Reaction catalysed
an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione <=> an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)
Comment(s)
  • This mammalian enzyme, which is cytosolic, can bind internalized alkylcobalamins and process them to cob(I)alamin using the thiolate of glutathione for nucleophilic displacement.
  • The product remains bound to the protein, and, following its oxidation to cob(II)alamin, is transferred by the enzyme, together with its interacting partner MMADHC, directly to downstream enzymes involved in adenosylcobalamin and methylcobalamin biosynthesis.
  • In addition to its dealkylase function, the enzyme also catalyze an entirely different decyanase reaction with cyanocobalamin (cf. EC 1.16.1.6).
Cross-references
BRENDA2.5.1.151
EC2PDB2.5.1.151
ExplorEnz2.5.1.151
PRIAM enzyme-specific profiles2.5.1.151
KEGG Ligand Database for Enzyme Nomenclature2.5.1.151
IUBMB Enzyme Nomenclature2.5.1.151
IntEnz2.5.1.151
MEDLINEFind literature relating to 2.5.1.151
MetaCyc2.5.1.151
Rhea expert-curated reactions2.5.1.151
UniProtKB/Swiss-Prot
Q5E9C8, MMAC_BOVIN;  Q5ZL21, MMAC_CHICK;  Q5RFU5, MMAC_DANRE;  
Q9Y4U1, MMAC_HUMAN;  Q9CZD0, MMAC_MOUSE;  

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