ENZYME

Home | Contact

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.5.1.151

Accepted Name
Alkylcobalamin dealkylase.
Reaction catalysed
An alkylcobalamin + [alkylcobalamin reductase] + glutathione <=> cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione
Comment(s)
This mammalian enzyme, which is cytosolic, can bind internalized alkylcobalamins and process them to cob(I)alamin using the thiolate of glutathione for nucleophilic displacement. The product remains bound to the protein, and, following its oxidation to cob(II)alamin, is transferred by the enzyme, together with its interacting partner MMADHC, directly to downstream enzymes involved in adenosylcobalamin and methylcobalamin biosynthesis. In addition to its dealkylase function, the enzyme also catalyze an entirely different decyanase reaction with cyanocobalamin (cf. EC 1.16.1.6).
Cross-references
BRENDA	2.5.1.151
EC2PDB	2.5.1.151
ExplorEnz	2.5.1.151
PRIAM enzyme-specific profiles	2.5.1.151
KEGG Ligand Database for Enzyme Nomenclature	2.5.1.151
IUBMB Enzyme Nomenclature	2.5.1.151
IntEnz	2.5.1.151
MEDLINE	Find literature relating to 2.5.1.151
MetaCyc	2.5.1.151