A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 184.108.40.206
View entry in original ENZYME format
View entry in raw text format (no links)
|An alkylcobalamin + [alkylcobalamin reductase] + glutathione <=> cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione|
- This mammalian enzyme, which is cytosolic, can bind internalized
alkylcobalamins and process them to cob(I)alamin using the thiolate
of glutathione for nucleophilic displacement.
- The product remains bound to the protein, and, following its
oxidation to cob(II)alamin, is transferred by the enzyme, together
with its interacting partner MMADHC, directly to downstream enzymes
involved in adenosylcobalamin and methylcobalamin biosynthesis.
- In addition to its dealkylase function, the enzyme also catalyze an
entirely different decyanase reaction with cyanocobalamin (cf.
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-