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ENZYME entry: EC

Accepted Name
Alkylcobalamin dealkylase.
Reaction catalysed
An alkylcobalamin + [alkylcobalamin reductase] + glutathione <=> cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione
  • This mammalian enzyme, which is cytosolic, can bind internalized alkylcobalamins and process them to cob(I)alamin using the thiolate of glutathione for nucleophilic displacement.
  • The product remains bound to the protein, and, following its oxidation to cob(II)alamin, is transferred by the enzyme, together with its interacting partner MMADHC, directly to downstream enzymes involved in adenosylcobalamin and methylcobalamin biosynthesis.
  • In addition to its dealkylase function, the enzyme also catalyze an entirely different decyanase reaction with cyanocobalamin (cf. EC
PRIAM enzyme-specific profiles2.5.1.151
KEGG Ligand Database for Enzyme Nomenclature2.5.1.151
IUBMB Enzyme Nomenclature2.5.1.151
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