ENZYME entry: EC 2.5.1.151
| Accepted Name |
|---|
| Alkylcobalamin dealkylase.
|
| Reaction catalysed |
|---|
| An alkylcobalamin + [alkylcobalamin reductase] + glutathione <=> cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione |
| Comment(s) |
|---|
- This mammalian enzyme, which is cytosolic, can bind internalized
alkylcobalamins and process them to cob(I)alamin using the thiolate
of glutathione for nucleophilic displacement.
- The product remains bound to the protein, and, following its
oxidation to cob(II)alamin, is transferred by the enzyme, together
with its interacting partner MMADHC, directly to downstream enzymes
involved in adenosylcobalamin and methylcobalamin biosynthesis.
- In addition to its dealkylase function, the enzyme also catalyze an
entirely different decyanase reaction with cyanocobalamin (cf.
EC 1.16.1.6).
|
| Cross-references |
|---|
| BRENDA | 2.5.1.151 |
| EC2PDB | 2.5.1.151 |
| ExplorEnz | 2.5.1.151 |
| PRIAM enzyme-specific profiles | 2.5.1.151 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.151 |
| IUBMB Enzyme Nomenclature | 2.5.1.151 |
| IntEnz | 2.5.1.151 |
| MEDLINE | Find literature relating to 2.5.1.151 |
| MetaCyc | 2.5.1.151 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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