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ENZYME entry: EC

Accepted Name
Alternative Name(s)
copper efflux oxidase.
Cu(I) oxidase.
cuprous oxidase.
Reaction catalysed
4 Cu(+) + 4 H(+) + O2 <=> 4 Cu(2+) + 2 H2O
  • The enzyme, characterized from the bacterium Escherichia coli, is involved in copper tolerance under aerobic conditions.
  • The enzyme contains a substrate binding (type 1) copper site and a trinuclear copper center (consisting of type 2 and type 3 copper sites) in which oxygen binding and reduction takes place.
  • It also contains a methionine rich region that can bind additional copper ions. In vitro, if the substrate binding site is occupied by copper(II), the enzyme can function as a laccase-type quinol oxidase.
  • However, in vivo this site is occupied by a copper(I) ion and the enzyme functions as a cuprous oxidase.
PRIAM enzyme-specific profiles1.16.3.4
KEGG Ligand Database for Enzyme Nomenclature1.16.3.4
IUBMB Enzyme Nomenclature1.16.3.4
MEDLINEFind literature relating to
Rhea expert-curated reactions1.16.3.4

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.16.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.16.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-