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ENZYME

ENZYME entry: EC 1.16.3.4

PURL: https://purl.expasy.org/enzyme/EC/1.16.3.4
Accepted Name
cuproxidase
Alternative Name(s)
copper efflux oxidase
Cu(I) oxidase
cuprous oxidase
Reaction catalysed
4 Cu(+) + O2 + 4 H(+) = 4 Cu(2+) + 2 H2O
Comment(s)
  • The enzyme, characterized from the bacterium Escherichia coli, is involved in copper tolerance under aerobic conditions.
  • The enzyme contains a substrate binding (type 1) copper site and a trinuclear copper center (consisting of type 2 and type 3 copper sites) in which oxygen binding and reduction takes place.
  • It also contains a methionine rich region that can bind additional copper ions. In vitro, if the substrate binding site is occupied by copper(II), the enzyme can function as a laccase-type quinol oxidase.
  • However, in vivo this site is occupied by a copper(I) ion and the enzyme functions as a cuprous oxidase.
Cross-references
BRENDA1.16.3.4
EC2PDB1.16.3.4
ExplorEnz1.16.3.4
KEGG Ligand Database for Enzyme Nomenclature1.16.3.4
IUBMB Enzyme Nomenclature1.16.3.4
MEDLINEFind literature relating to 1.16.3.4
MetaCyc1.16.3.4
Rhea expert-curated reactions1.16.3.4
UniProtKB/Swiss-Prot
P00450, CERU_HUMANQ61147, CERU_MOUSEP13635, CERU_RAT
Q9XT27, CERU_SHEEPQ8X947, CUEO_ECO57P36649, CUEO_ECOLI
Q8Z9E1, CUEO_SALTIQ8ZRS2, CUEO_SALTYQ8ZBK0, CUEO_YERPE
P38993, FET3_YEAST

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