ENZYME entry: EC 1.17.1.5
| Accepted Name |
|---|
| Nicotinate dehydrogenase.
|
| Alternative Name(s) |
|---|
| Nicotinate hydroxylase. |
| Nicotinic acid hydroxylase. |
| Reaction catalysed |
|---|
| Nicotinate + H(2)O + NADP(+) <=> 6-hydroxynicotinate + NADPH |
| Cofactor(s) |
|---|
| Fe cation; Flavoprotein.
|
| Comment(s) |
|---|
- The enzyme is capable of acting on a variety of nicotinate analogs to
varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3-
dicarboxylate, trigonelline and 6-methylnicotinate.
- The enzyme from Clostridium barkeri also possesses a catalytically
essential, labile selenium that can be removed by reaction with
cyanide.
- Forms part of the nicotinate-fermentation catabolism pathway in
Eubacterium barkeri.
- Other enzymes involved in this pathway are EC 1.3.7.1, EC 3.5.2.18,
EC 1.1.1.291, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.
- Formerly EC 1.5.1.13.
|
| Cross-references |
|---|
| BRENDA | 1.17.1.5 |
| EC2PDB | 1.17.1.5 |
| ExplorEnz | 1.17.1.5 |
| PRIAM enzyme-specific profiles | 1.17.1.5 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.17.1.5 |
| IUBMB Enzyme Nomenclature | 1.17.1.5 |
| IntEnz | 1.17.1.5 |
| MEDLINE | Find literature relating to 1.17.1.5 |
| MetaCyc | 1.17.1.5 |
| UniProtKB/Swiss-Prot |
|
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