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ENZYME entry: EC 1.17.1.5

Accepted Name
Nicotinate dehydrogenase.
Alternative Name(s)
Nicotinate hydroxylase.
Nicotinic acid hydroxylase.
Reaction catalysed
Nicotinate + H(2)O + NADP(+) <=> 6-hydroxynicotinate + NADPH
Cofactor(s)
Fe cation; Flavoprotein.
Comment(s)
  • The enzyme is capable of acting on a variety of nicotinate analogs to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3- dicarboxylate, trigonelline and 6-methylnicotinate.
  • The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide.
  • Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri.
  • Other enzymes involved in this pathway are EC 1.3.7.1, EC 3.5.2.18, EC 1.1.1.291, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.
  • Formerly EC 1.5.1.13.
Cross-references
BRENDA1.17.1.5
EC2PDB1.17.1.5
ExplorEnz1.17.1.5
PRIAM enzyme-specific profiles1.17.1.5
KEGG Ligand Database for Enzyme Nomenclature1.17.1.5
IUBMB Enzyme Nomenclature1.17.1.5
IntEnz1.17.1.5
MEDLINEFind literature relating to 1.17.1.5
MetaCyc1.17.1.5
Rhea expert-curated reactions1.17.1.5
UniProtKB/Swiss-Prot
Q0QLF4, NDFS_EUBBA;  Q0QLF2, NDLMS_EUBBA;  Q0QLF1, NDMMS_EUBBA;  
Q0QLF3, NDSFS_EUBBA;  

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