ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.17.1.5

Accepted Name

Nicotinate dehydrogenase.

Alternative Name(s)

Nicotinate hydroxylase.

Nicotinic acid hydroxylase.

Reaction catalysed

Nicotinate + H(2)O + NADP(+) <=> 6-hydroxynicotinate + NADPH

Cofactor(s)

Fe cation; Flavoprotein.

Comment(s)

The enzyme is capable of acting on a variety of nicotinate analogs to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3- dicarboxylate, trigonelline and 6-methylnicotinate.
The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide.
Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri.
Other enzymes involved in this pathway are EC 1.3.7.1, EC 3.5.2.18, EC 1.1.1.291, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.
Formerly EC 1.5.1.13.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature