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ENZYME entry: EC 1.17.5.1

Accepted Name
Phenylacetyl-CoA dehydrogenase.
Alternative Name(s)
Phenylacetyl-CoA:acceptor oxidoreductase.
Reaction catalysed
Phenylacetyl-CoA + H(2)O + 2 quinone <=> phenylglyoxylyl-CoA + 2 quinol
Cofactor(s)
Iron-sulfur; Mo-molybdopterin.
Comment(s)
  • The enzyme is specific for phenylacetyl-CoA as substrate.
  • Phenylacetate, acetyl-CoA, benzoyl-CoA, propanoyl-CoA, crotonyl-CoA, succinyl-CoA and 3-hydroxybenzoyl-CoA cannot act as substrates.
  • The oxygen atom introduced into the product, phenylglyoxylyl-CoA, is derived from water and not molecular oxygen.
  • Duroquinone, menaquinone and 2,6-dichlorophenolindophenol (DCPIP) can act as acceptor, but the likely physiological acceptor is ubiquinone.
  • A second enzyme, EC 3.1.2.25 converts the phenylglyoxylyl-CoA formed into phenylglyoxylate.
Cross-references
BRENDA1.17.5.1
EC2PDB1.17.5.1
ExplorEnz1.17.5.1
PRIAM enzyme-specific profiles1.17.5.1
KEGG Ligand Database for Enzyme Nomenclature1.17.5.1
IUBMB Enzyme Nomenclature1.17.5.1
IntEnz1.17.5.1
MEDLINEFind literature relating to 1.17.5.1
MetaCyc1.17.5.1
Rhea expert-curated reactions1.17.5.1

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