A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_09. Read more about EC 7 here.
ENZYME entry: EC 1.17.7.1
| Accepted Name |
|---|
| (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin).
|
| Alternative Name(s) |
|---|
| (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase. |
| 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase. |
| Reaction catalysed |
|---|
| (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + 2 oxidized ferredoxin <=> 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin |
| Cofactor(s) |
|---|
| Iron-sulfur.
|
| Comment(s) |
|---|
- Forms part of an alternative non-mevalonate pathway for isoprenoid
biosynthesis.
- Bacteria have a similar enzyme that uses flavodoxin rather than
ferredoxin (cf. EC 1.17.7.3).
- The enzyme from the plant Arabidopsis thaliana is active with
photoreduced 5-deazaflavin but not with flavodoxin.
- Formerly EC 1.17.4.3.
|
| Cross-references |
|---|
| BRENDA | 1.17.7.1 |
| EC2PDB | 1.17.7.1 |
| ExplorEnz | 1.17.7.1 |
| PRIAM enzyme-specific profiles | 1.17.7.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.17.7.1 |
| IUBMB Enzyme Nomenclature | 1.17.7.1 |
| IntEnz | 1.17.7.1 |
| MEDLINE | Find literature relating to 1.17.7.1 |
| MetaCyc | 1.17.7.1 |
| UniProtKB/Swiss-Prot |
| B0C6E1, ISPG_ACAM1; | Q3MG27, ISPG_ANAVT; | F4K0E8, ISPG_ARATH; |
| B1WQF1, ISPG_CYAA5; | B8HSI6, ISPG_CYAP4; | B7KJJ4, ISPG_CYAP7; |
| B7K5R5, ISPG_CYAP8; | Q7NFA4, ISPG_GLOVI; | B0JJJ8, ISPG_MICAN; |
| B2J1G1, ISPG_NOSP7; | P58666, ISPG_NOSS1; | Q6K8J4, ISPG_ORYSJ; |
| Q7VBS7, ISPG_PROMA; | Q7V7G9, ISPG_PROMM; | Q7V215, ISPG_PROMP; |
| Q31QC4, ISPG_SYNE7; | Q2JS69, ISPG_SYNJA; | Q2JPZ9, ISPG_SYNJB; |
| B1XHZ7, ISPG_SYNP2; | Q5N3W3, ISPG_SYNP6; | Q7U712, ISPG_SYNPX; |
| Q0I9J4, ISPG_SYNS3; | Q3AXP3, ISPG_SYNS9; | Q3AK30, ISPG_SYNSC; |
| P73672, ISPG_SYNY3; | Q8DK70, ISPG_THEEB; | Q10W70, ISPG_TRIEI; |
|
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