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ENZYME

ENZYME entry: EC 1.17.7.1

PURL: https://purl.expasy.org/enzyme/EC/1.17.7.1
Accepted Name
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)
Alternative Name(s)
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
Reaction catalysed
(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + H(+)
Comment(s)
  • Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis.
  • Bacteria have a similar enzyme that uses flavodoxin rather than ferredoxin (cf. EC 1.17.7.3).
  • The enzyme from the plant Arabidopsis thaliana is active with photoreduced 5-deazaflavin but not with flavodoxin.
  • Formerly EC 1.17.4.3.
Cross-references
BRENDA1.17.7.1
EC2PDB1.17.7.1
ExplorEnz1.17.7.1
KEGG Ligand Database for Enzyme Nomenclature1.17.7.1
IUBMB Enzyme Nomenclature1.17.7.1
MEDLINEFind literature relating to 1.17.7.1
MetaCyc1.17.7.1
Rhea expert-curated reactions1.17.7.1
UniProtKB/Swiss-Prot
B0C6E1, ISPG_ACAM1F4K0E8, ISPG_ARATHB1WQF1, ISPG_CROS5
B8HSI6, ISPG_CYAP4B7KJJ4, ISPG_GLOC7Q7NFA4, ISPG_GLOVI
B0JJJ8, ISPG_MICANB2J1G1, ISPG_NOSP7P58666, ISPG_NOSS1
Q6K8J4, ISPG_ORYSJQ7U712, ISPG_PARMWB1XHZ7, ISPG_PICP2
Q7VBS7, ISPG_PROMAQ7V7G9, ISPG_PROMMQ7V215, ISPG_PROMP
B7K5R5, ISPG_RIPO1Q31QC4, ISPG_SYNE7Q2JS69, ISPG_SYNJA
Q2JPZ9, ISPG_SYNJBQ5N3W3, ISPG_SYNP6Q0I9J4, ISPG_SYNS3
Q3AXP3, ISPG_SYNS9Q3AK30, ISPG_SYNSCP73672, ISPG_SYNY3
Q8DK70, ISPG_THEVBQ10W70, ISPG_TRIEIQ3MG27, ISPG_TRIV2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-