Expasy logo

ENZYME

ENZYME entry: EC 1.17.7.1

PURL: https://purl.expasy.org/enzyme/EC/1.17.7.1
Accepted Name
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)
Alternative Name(s)
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
Reaction catalysed
(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + H(+)
Comment(s)
  • Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis.
  • Bacteria have a similar enzyme that uses flavodoxin rather than ferredoxin (cf. EC 1.17.7.3).
  • The enzyme from the plant Arabidopsis thaliana is active with photoreduced 5-deazaflavin but not with flavodoxin.
  • Formerly EC 1.17.4.3.
Cross-references
Rhea expert-curated reactions1.17.7.1
ExplorEnz1.17.7.1
IUBMB Enzyme Nomenclature1.17.7.1
UniProtKB/Swiss-Prot
B0C6E1, ISPG_ACAM1F4K0E8, ISPG_ARATHB1WQF1, ISPG_CROS5
B8HSI6, ISPG_CYAP4B7KJJ4, ISPG_GLOC7Q7NFA4, ISPG_GLOVI
B0JJJ8, ISPG_MICANB2J1G1, ISPG_NOSP7P58666, ISPG_NOSS1
Q6K8J4, ISPG_ORYSJQ7U712, ISPG_PARMWB1XHZ7, ISPG_PICP2
Q7VBS7, ISPG_PROMAQ7V7G9, ISPG_PROMMQ7V215, ISPG_PROMP
B7K5R5, ISPG_RIPO1Q31QC4, ISPG_SYNE7Q2JS69, ISPG_SYNJA
Q2JPZ9, ISPG_SYNJBQ5N3W3, ISPG_SYNP6Q0I9J4, ISPG_SYNS3
Q3AXP3, ISPG_SYNS9Q3AK30, ISPG_SYNSCP73672, ISPG_SYNY3
Q8DK70, ISPG_THEVBQ10W70, ISPG_TRIEIQ3MG27, ISPG_TRIV2
BRENDA1.17.7.1
MetaCyc1.17.7.1
KEGG Ligand Database for Enzyme Nomenclature1.17.7.1
EC2PDB1.17.7.1
MEDLINEFind literature relating to 1.17.7.1

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-