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ENZYME

ENZYME entry: EC 1.17.7.3

PURL: https://purl.expasy.org/enzyme/EC/1.17.7.3
Accepted Name
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)
Alternative Name(s)
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
Reaction catalysed
(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + oxidized [flavodoxin] + H2O + 2 H(+) = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]
Comment(s)
  • Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria.
  • Plants and cyanobacteria have a similar enzyme that utilizes ferredoxin rather than flavodoxin (cf. EC 1.17.7.1).
Cross-references
BRENDA1.17.7.3
EC2PDB1.17.7.3
ExplorEnz1.17.7.3
KEGG Ligand Database for Enzyme Nomenclature1.17.7.3
IUBMB Enzyme Nomenclature1.17.7.3
MEDLINEFind literature relating to 1.17.7.3
MetaCyc1.17.7.3
Rhea expert-curated reactions1.17.7.3
UniProtKB/Swiss-Prot
Q82K43, ISPG1_STRAWQ9X7W2, ISPG1_STRCOQ82ML3, ISPG2_STRAW
Q9KYR9, ISPG2_STRCOQ6FEM3, ISPG_ACIADB7H069, ISPG_ACIB3
B7I5G7, ISPG_ACIB5B2I3E5, ISPG_ACIBCB0VKR8, ISPG_ACIBS
A3M211, ISPG_ACIBTB0V5G7, ISPG_ACIBYA0LV34, ISPG_ACIC1
A5FX97, ISPG_ACICJB7JC30, ISPG_ACIF2B5EJF3, ISPG_ACIF5
A3N1H8, ISPG_ACTP2B3GY64, ISPG_ACTP7B0BQB9, ISPG_ACTPJ
A6VQX6, ISPG_ACTSZB6JA27, ISPG_AFIC5P58665, ISPG_AGRFC
B2UKT9, ISPG_AKKM8Q0VNE0, ISPG_ALCBSQ5E772, ISPG_ALIF1
B5FAX2, ISPG_ALIFMB6EGY7, ISPG_ALISLB9JV07, ISPG_ALLAM
B4RV89, ISPG_ALTMDQ5PAJ1, ISPG_ANAMMB7GH89, ISPG_ANOFW
O67496, ISPG_AQUAEQ5P7B3, ISPG_AROAEA0JUS8, ISPG_ARTS2
C1DE57, ISPG_AZOVDC3P8I5, ISPG_BACAAC3LKV7, ISPG_BACAC
A0RIQ2, ISPG_BACAHQ81LV7, ISPG_BACANB7JN03, ISPG_BACC0
Q730Q8, ISPG_BACC1B7IYD0, ISPG_BACC2C1ES01, ISPG_BACC3
B7HCQ3, ISPG_BACC4B7HPH8, ISPG_BACC7A7GSX5, ISPG_BACCN
B9IY45, ISPG_BACCQQ818H8, ISPG_BACCRQ634Q9, ISPG_BACCZ
Q5L7W2, ISPG_BACFNQ64N34, ISPG_BACFRQ6HDN9, ISPG_BACHK
Q65HA9, ISPG_BACLDA9VH61, ISPG_BACMKA8FF87, ISPG_BACP2
P54482, ISPG_BACSUQ8A4T0, ISPG_BACTNA7Z6S2, ISPG_BACVZ
A1UR54, ISPG_BARBKQ6G1X4, ISPG_BARHEQ6G104, ISPG_BARQU
A9IYW1, ISPG_BART1Q1LU77, ISPG_BAUCHB2IE63, ISPG_BEII9
Q8G7Y6, ISPG_BIFLOQ492E0, ISPG_BLOPBQ7WHN0, ISPG_BORBR
Q7W6P6, ISPG_BORPAQ7VWL0, ISPG_BORPEQ89VV9, ISPG_BRADU
A5ETI5, ISPG_BRASBA4YKQ8, ISPG_BRASOC0ZF58, ISPG_BREBN
B2S7K6, ISPG_BRUA1Q2YLG4, ISPG_BRUA2A6WXY9, ISPG_BRUA4
Q57BA5, ISPG_BRUABA9M820, ISPG_BRUC2C0RF32, ISPG_BRUMB
Q8YJ17, ISPG_BRUMEA9WWQ2, ISPG_BRUSIQ8FYT2, ISPG_BRUSU
P57374, ISPG_BUCAIQ8K9P4, ISPG_BUCAPB1YR44, ISPG_BURA4
B4EAW9, ISPG_BURCJA3MK75, ISPG_BURM7A2S2A2, ISPG_BURM9
Q62JW4, ISPG_BURMAA1V4K1, ISPG_BURMSA3NVX1, ISPG_BURP0
Q3JRQ3, ISPG_BURP1A3NA54, ISPG_BURP6Q63UT3, ISPG_BURPS
Q8RA30, ISPG_CALS4A4XLZ4, ISPG_CALS8A7ZCT9, ISPG_CAMC1
A7GZ54, ISPG_CAMC5A0RPL8, ISPG_CAMFFA8FLB6, ISPG_CAMJ8
A7H4D8, ISPG_CAMJDQ9PPM1, ISPG_CAMJEA1VZ41, ISPG_CAMJJ
Q5HV95, ISPG_CAMJRB9KD64, ISPG_CAMLRQ9A9W0, ISPG_CAUVC
B3PDM1, ISPG_CELJUQ5L669, ISPG_CHLABQ823I7, ISPG_CHLCV
Q254D2, ISPG_CHLFFQ9PKY3, ISPG_CHLMUQ9Z8H0, ISPG_CHLPN
B0B9G5, ISPG_CHLT2Q3KMW4, ISPG_CHLTAB0BB44, ISPG_CHLTB
Q8KG23, ISPG_CHLTEO84060, ISPG_CHLTRQ1QTK8, ISPG_CHRI1
Q7NS88, ISPG_CHRVOA8AD71, ISPG_CITK8A5CT01, ISPG_CLAM3
B0RDZ5, ISPG_CLASEQ97I56, ISPG_CLOABP58667, ISPG_CLOPE
Q895K3, ISPG_CLOTEQ47WC0, ISPG_COLP3Q6NGL3, ISPG_CORDI
Q8FP82, ISPG_COREFQ8NP12, ISPG_CORGLQ4JV28, ISPG_CORJK
B1VGA4, ISPG_CORU7A7MGV7, ISPG_CROS8Q6A7L2, ISPG_CUTAK
Q47BR6, ISPG_DECARA5FS85, ISPG_DEHMBQ3ZZC9, ISPG_DEHMC
Q9RXC9, ISPG_DEIRAQ6AP32, ISPG_DESPSA8LI72, ISPG_DINSH
A7ZPV8, ISPG_ECO24B7UGW1, ISPG_ECO27B7MI00, ISPG_ECO45
B7LDA7, ISPG_ECO55P62622, ISPG_ECO57B5Z0Y4, ISPG_ECO5E
B7NRG5, ISPG_ECO7IB7MYF0, ISPG_ECO81B7M7L9, ISPG_ECO8A
C4ZX90, ISPG_ECOBWB1XAZ0, ISPG_ECODHA8A321, ISPG_ECOHS
A1AE53, ISPG_ECOK1Q0TEX0, ISPG_ECOL5P62621, ISPG_ECOL6
B1IWE6, ISPG_ECOLCP62620, ISPG_ECOLIB7N6A3, ISPG_ECOLU
B6I587, ISPG_ECOSEB1LNH0, ISPG_ECOSMQ1R8L8, ISPG_ECOUT
A4XY32, ISPG_ECTM1Q3YRZ7, ISPG_EHRCJQ5FHA6, ISPG_EHRRG
Q5HB57, ISPG_EHRRWA4WD93, ISPG_ENT38B2VE89, ISPG_ERWT9
B7LKC3, ISPG_ESCF3B1YLA2, ISPG_EXIS2C4L3K5, ISPG_EXISA
Q0RDR2, ISPG_FRAAAQ2J717, ISPG_FRACCQ14IL6, ISPG_FRAT1
B2SG03, ISPG_FRATMA0Q6U8, ISPG_FRATNQ0BMA6, ISPG_FRATO
Q5NH64, ISPG_FRATTQ8RG40, ISPG_FUSNNQ5KX35, ISPG_GEOKA
Q74D60, ISPG_GEOSLC5D4Q3, ISPG_GEOSWA4IQZ4, ISPG_GEOTN
A9HJ48, ISPG_GLUDAQ5FUR7, ISPG_GLUOXQ0BUK0, ISPG_GRABC
Q7VME2, ISPG_HAEDUQ4QNH4, ISPG_HAEI8A5UAB9, ISPG_HAEIE
A5UGH1, ISPG_HAEIGP44667, ISPG_HAEINQ2SDW4, ISPG_HAHCH
Q9KD18, ISPG_HALH5C4K4I8, ISPG_HAMD5Q17XU2, ISPG_HELAH
Q7VI04, ISPG_HELHPB6JLL3, ISPG_HELP2B5Z6Z7, ISPG_HELPG
Q1CTP7, ISPG_HELPHQ9ZLL0, ISPG_HELPJB2UTK0, ISPG_HELPS
O25342, ISPG_HELPYQ0I2E9, ISPG_HISS1B0USG8, ISPG_HISS2
B4U9V3, ISPG_HYDS0Q0C4J3, ISPG_HYPNAQ5QYA9, ISPG_IDILO
Q28R10, ISPG_JANSCA6TCD4, ISPG_KLEP7B5XNL5, ISPG_KLEV3
B2GKS3, ISPG_KOCRDQ1IRS5, ISPG_KORVEC1DD43, ISPG_LARHH
Q1MSE5, ISPG_LAWIPQ6AEX9, ISPG_LEIXXQ04UL2, ISPG_LEPBJ
Q04YW2, ISPG_LEPBLQ72TR2, ISPG_LEPICQ8F1H5, ISPG_LEPIN
C1L2Z7, ISPG_LISMCQ71ZM9, ISPG_LISMFP58668, ISPG_LISMO
B1HSS4, ISPG_LYSSCB9E6U1, ISPG_MACCJA0LDN3, ISPG_MAGMM
Q8EUI6, ISPG_MALP2Q65R84, ISPG_MANSMA6VV06, ISPG_MARMS
A1TZQ0, ISPG_MARN8C6BYK9, ISPG_MARSDQ604Q5, ISPG_METCA
Q1H0U9, ISPG_METFKQ7TXN6, ISPG_MYCBOA1KML3, ISPG_MYCBP
C1AFY4, ISPG_MYCBTQ7NBH3, ISPG_MYCGAB8ZRU5, ISPG_MYCLB
Q9CBU5, ISPG_MYCLEQ73VS3, ISPG_MYCPAA5U6M2, ISPG_MYCTA
P9WKG2, ISPG_MYCTOP9WKG3, ISPG_MYCTUB2A390, ISPG_NATTJ
B9LA27, ISPG_NAUPAQ5F913, ISPG_NEIG1B4RMG4, ISPG_NEIG2
A9LZN8, ISPG_NEIM0Q9JU34, ISPG_NEIMAQ9JZ40, ISPG_NEIMB
A1KUD8, ISPG_NEIMFQ0AE42, ISPG_NITECQ82XV0, ISPG_NITEU
Q1QQI9, ISPG_NITHXA6Q1U2, ISPG_NITSBQ72CD9, ISPG_NITV2
Q3SVD0, ISPG_NITWNQ5YS74, ISPG_NOCFAA1R501, ISPG_PAEAT
A6LGR5, ISPG_PARD8A1B323, ISPG_PARDPA8L6E2, ISPG_PARS2
Q6MD85, ISPG_PARUWP57987, ISPG_PASMUQ6D276, ISPG_PECAS
C6DBH4, ISPG_PECCPQ4FNA0, ISPG_PELUBC0QRI5, ISPG_PERMH
Q7N706, ISPG_PHOLLQ6LU49, ISPG_PHOPRA6L089, ISPG_PHOV8
Q7MVT7, ISPG_PORGIB4EZT3, ISPG_PROMHP72241, ISPG_PROST
Q48LZ4, ISPG_PSE14B7UWI8, ISPG_PSEA8Q02RV7, ISPG_PSEAB
Q9HXJ4, ISPG_PSEAEB8HG44, ISPG_PSECPQ1IEI1, ISPG_PSEE4
Q4K6U9, ISPG_PSEF5C3K1L4, ISPG_PSEFSA8F4Y8, ISPG_PSELT
A5VYT5, ISPG_PSEP1A6V0W0, ISPG_PSEP7Q3K7B6, ISPG_PSEPF
B0KPI7, ISPG_PSEPGQ88PJ7, ISPG_PSEPKB1JDV8, ISPG_PSEPW
Q886Z0, ISPG_PSESMQ3ICZ5, ISPG_PSET1Q4ZX23, ISPG_PSEU2
Q4FTW7, ISPG_PSYA2Q1QD18, ISPG_PSYCKA1SU39, ISPG_PSYIN
P58669, ISPG_RALN1B2U9U9, ISPG_RALPJA9WR14, ISPG_RENSM
B3PR71, ISPG_RHIE6Q2K333, ISPG_RHIECQ1MAC5, ISPG_RHIJ3
Q98FG0, ISPG_RHILOB5ZUA0, ISPG_RHILWQ92L19, ISPG_RHIME
B9JE02, ISPG_RHIR8Q7UWC8, ISPG_RHOBAC1B2V4, ISPG_RHOOB
Q2J2S7, ISPG_RHOP2Q07V91, ISPG_RHOP5Q6NCF3, ISPG_RHOPA
Q21C20, ISPG_RHOPBB3QBC6, ISPG_RHOPTQ2RWE4, ISPG_RHORT
Q5LQ99, ISPG_RUEPOQ1GIC1, ISPG_RUESTB8I6E1, ISPG_RUMCH
A1AW46, ISPG_RUTMCQ21KT3, ISPG_SACD2B5F198, ISPG_SALA4
A8M723, ISPG_SALAIA9MHL5, ISPG_SALARQ57LI6, ISPG_SALCH
B5FR63, ISPG_SALDCB5R582, ISPG_SALEPB5RCZ2, ISPG_SALG2
B4TD93, ISPG_SALHSB4T0P9, ISPG_SALNSQ5PNI2, ISPG_SALPA
A9N201, ISPG_SALPBB5BAY5, ISPG_SALPKB4TR95, ISPG_SALSV
P58670, ISPG_SALTIA4X4L9, ISPG_SALTOP58671, ISPG_SALTY
A8GHW5, ISPG_SERP5A1S863, ISPG_SHEAMB8E9S7, ISPG_SHEB2
A3D6V9, ISPG_SHEB5A6WQP7, ISPG_SHEB8A9KXK8, ISPG_SHEB9
Q12PT4, ISPG_SHEDOQ085U6, ISPG_SHEFNB0TLI4, ISPG_SHEHH
A3QCG2, ISPG_SHELPQ8EC32, ISPG_SHEONA8H245, ISPG_SHEPA
A4Y8U0, ISPG_SHEPCB8CKR1, ISPG_SHEPWA0KUJ5, ISPG_SHESA
A8FT70, ISPG_SHESHQ0HKV9, ISPG_SHESMQ0HX57, ISPG_SHESR
A1RHQ3, ISPG_SHESWB1KKJ2, ISPG_SHEWMB2TXU0, ISPG_SHIB3
Q31XX5, ISPG_SHIBSQ32D47, ISPG_SHIDSQ0T204, ISPG_SHIF8
Q83K43, ISPG_SHIFLQ3YZ37, ISPG_SHISSQ5WHB2, ISPG_SHOC1
C3MAL6, ISPG_SINFNA6UE79, ISPG_SINMWQ2NS40, ISPG_SODGM
Q029T9, ISPG_SOLUEB1VYP5, ISPG_STRGGB4SRZ0, ISPG_STRM5
B2FL74, ISPG_STRMKQ30TM4, ISPG_SULDNA6QC65, ISPG_SULNB
B2V7Y2, ISPG_SULSYQ67PA7, ISPG_SYMTHB7IFY1, ISPG_THEAB
Q47RY0, ISPG_THEFYQ9WZZ3, ISPG_THEMAA5IIP2, ISPG_THEP1
B1LC43, ISPG_THESQQ72H18, ISPG_THET2Q5SLI8, ISPG_THET8
Q84GJ3, ISPG_THETHB5YIQ4, ISPG_THEYDQ73N90, ISPG_TREDE
O83460, ISPG_TREPAQ83NE4, ISPG_TROW8Q83N18, ISPG_TROWT
A5CX35, ISPG_VESOHB7VJT8, ISPG_VIBA3A7MU42, ISPG_VIBC1
Q9KTX1, ISPG_VIBCHQ87S16, ISPG_VIBPAQ8DEZ8, ISPG_VIBVU
Q7MNF1, ISPG_VIBVYQ8D1Y3, ISPG_WIGBRQ73IP1, ISPG_WOLPM
B3CNN4, ISPG_WOLPPQ7M8Z2, ISPG_WOLSUQ5GRK4, ISPG_WOLTR
C0R5E5, ISPG_WOLWRQ8PLJ8, ISPG_XANACQ4UTW8, ISPG_XANC8
B0RTS9, ISPG_XANCBQ8P9R7, ISPG_XANCPQ3BUK3, ISPG_XANE5
Q2P3M7, ISPG_XANOMQ5H0N8, ISPG_XANORQ9PAE3, ISPG_XYLFA
Q87A73, ISPG_XYLFTA1JKS2, ISPG_YERE8A7FFY9, ISPG_YERP3
Q1C5I8, ISPG_YERPAB2K9Q0, ISPG_YERPBP58672, ISPG_YERPE
A9R802, ISPG_YERPGQ1CK91, ISPG_YERPNA4TMT7, ISPG_YERPP
Q667Z9, ISPG_YERPSB1JS05, ISPG_YERPYQ5NR50, ISPG_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-