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ENZYME entry: EC 1.17.7.4

Accepted Name
4-hydroxy-3-methylbut-2-enyl diphosphate reductase.
Alternative Name(s)
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase.
HMBPP reductase.
Reaction catalysed
  • Isopentenyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O <=> (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+)
  • Prenyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O <=> (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+)
Cofactor(s)
Iron-sulfur.
Comment(s)
  • Forms a system with a ferredoxin or a flavodoxin and an NAD(P)H-dependent reductase.
  • This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis.
  • This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts.
  • The enzyme acts in the reverse direction, producing a 5:1 mixture of isopentenyl diphosphate and prenyl diphosphate.
  • Formerly EC 1.17.1.2.
Cross-references
BRENDA1.17.7.4
EC2PDB1.17.7.4
ExplorEnz1.17.7.4
PRIAM enzyme-specific profiles1.17.7.4
KEGG Ligand Database for Enzyme Nomenclature1.17.7.4
IUBMB Enzyme Nomenclature1.17.7.4
IntEnz1.17.7.4
MEDLINEFind literature relating to 1.17.7.4
MetaCyc1.17.7.4
Rhea expert-curated reactions1.17.7.4
UniProtKB/Swiss-Prot
Q89UU5, ISPH1_BRADU;  Q629Z7, ISPH1_BURMA;  Q63WH0, ISPH1_BURPS;  
P0A5I1, ISPH1_MYCBO;  P9WKF8, ISPH1_MYCTO;  P9WKF9, ISPH1_MYCTU;  
Q6N3G0, ISPH1_RHOPA;  Q89QW7, ISPH2_BRADU;  Q62HM8, ISPH2_BURMA;  
P0DMK8, ISPH2_BURPS;  P0A5I3, ISPH2_MYCBO;  P9WKG0, ISPH2_MYCTO;  
P9WKG1, ISPH2_MYCTU;  Q6N1Y1, ISPH2_RHOPA;  B0C4N8, ISPH_ACAM1;  
Q9RBJ0, ISPH_ACIAD;  B7GVR1, ISPH_ACIB3;  B7IAU0, ISPH_ACIB5;  
B2HZW3, ISPH_ACIBC;  B0VQ53, ISPH_ACIBS;  A3M9H2, ISPH_ACIBT;  
B0V8K4, ISPH_ACIBY;  A0LW20, ISPH_ACIC1;  B7JBD6, ISPH_ACIF2;  
B5ERJ7, ISPH_ACIF5;  A3N2G8, ISPH_ACTP2;  B3GYK1, ISPH_ACTP7;  
B0BRB3, ISPH_ACTPJ;  A6VQH8, ISPH_ACTSZ;  A0KG42, ISPH_AERHH;  
A4SIX8, ISPH_AERS4;  P58673, ISPH_AGRFC;  B9JAQ2, ISPH_AGRRK;  
Q0VSD8, ISPH_ALCBS;  Q5E7N1, ISPH_ALIF1;  B5FA63, ISPH_ALIFM;  
B6ENC7, ISPH_ALISL;  Q9KD37, ISPH_ALKHC;  A6TRF9, ISPH_ALKMQ;  
A8MFE2, ISPH_ALKOO;  A7HCQ8, ISPH_ANADF;  B9KIX9, ISPH_ANAMF;  
Q5PAE7, ISPH_ANAMM;  B4UEK4, ISPH_ANASK;  B7GH78, ISPH_ANOFW;  
O67625, ISPH_AQUAE;  Q94B35, ISPH_ARATH;  Q5P224, ISPH_AROAE;  
B6YQB8, ISPH_AZOPC;  A1K4R4, ISPH_AZOSB;  C1DPH8, ISPH_AZOVD;  
C3P8J4, ISPH_BACAA;  C3LKW7, ISPH_BACAC;  A0RIR1, ISPH_BACAH;  
Q81LU9, ISPH_BACAN;  B7JN13, ISPH_BACC0;  Q730P8, ISPH_BACC1;  
B7IYD9, ISPH_BACC2;  C1ESI2, ISPH_BACC3;  B7HCR2, ISPH_BACC4;  
B7HPI8, ISPH_BACC7;  A7GSY4, ISPH_BACCN;  B9IY56, ISPH_BACCQ;  
Q634Q0, ISPH_BACCZ;  Q5L9K3, ISPH_BACFN;  Q64PU1, ISPH_BACFR;  
Q6HDN0, ISPH_BACHK;  Q65H97, ISPH_BACLD;  A9VHR7, ISPH_BACMK;  
A8FFA1, ISPH_BACP2;  Q5WHC6, ISPH_BACSK;  P54473, ISPH_BACSU;  
Q8A625, ISPH_BACTN;  A7Z6T1, ISPH_BACVZ;  A1URX2, ISPH_BARBK;  
Q6G4C5, ISPH_BARHE;  Q6G0C9, ISPH_BARQU;  A9IQQ9, ISPH_BART1;  
Q1LSS7, ISPH_BAUCH;  B2IED0, ISPH_BEII9;  Q8G4L8, ISPH_BIFLO;  
Q493S1, ISPH_BLOPB;  Q7WHF2, ISPH_BORBR;  Q7W9B4, ISPH_BORPA;  
Q7VYS2, ISPH_BORPE;  A0A2Z5WA18, ISPH_BOTBR;  C0ZL73, ISPH_BREBN;  
B2S9W9, ISPH_BRUA1;  A6WWG6, ISPH_BRUA4;  Q57EP6, ISPH_BRUAB;  
Q8YFR1, ISPH_BRUME;  Q8G257, ISPH_BRUSU;  B8D8U8, ISPH_BUCA5;  
P57247, ISPH_BUCAI;  Q8K9Z4, ISPH_BUCAP;  B8D752, ISPH_BUCAT;  
I1WW99, ISPH_BURP2;  Q8RA76, ISPH_CALS4;  A7ZCD0, ISPH_CAMC1;  
A7GXB5, ISPH_CAMC5;  A0RQC4, ISPH_CAMFF;  A7I0N0, ISPH_CAMHC;  
A8FLU3, ISPH_CAMJ8;  A7H3F3, ISPH_CAMJD;  P0C632, ISPH_CAMJE;  
A1VZM8, ISPH_CAMJJ;  Q5HUR4, ISPH_CAMJR;  B9KD74, ISPH_CAMLR;  
Q9A345, ISPH_CAUVC;  Q3J5X0, ISPH_CERS4;  A4WVQ4, ISPH_CERS5;  
Q11KC7, ISPH_CHESB;  Q5L5D3, ISPH_CHLAB;  Q3AT23, ISPH_CHLCH;  
Q822D9, ISPH_CHLCV;  Q255J4, ISPH_CHLFF;  B3EFF5, ISPH_CHLL2;  
Q3B241, ISPH_CHLL3;  Q9PL59, ISPH_CHLMU;  B3QQE0, ISPH_CHLP8;  
B3EM42, ISPH_CHLPB;  A1BDJ5, ISPH_CHLPD;  A4SGC0, ISPH_CHLPM;  
Q9Z6P2, ISPH_CHLPN;  B0B991, ISPH_CHLT2;  B3QSU2, ISPH_CHLT3;  
Q3KKH8, ISPH_CHLTA;  B0BAX0, ISPH_CHLTB;  Q8KFN9, ISPH_CHLTE;  
O84867, ISPH_CHLTR;  Q1R0B2, ISPH_CHRSD;  Q7NS59, ISPH_CHRVO;  
B5E9S9, ISPH_CITBB;  A8ALT3, ISPH_CITK8;  Q97I09, ISPH_CLOAB;  
Q187C6, ISPH_CLOD6;  Q0TRF3, ISPH_CLOP1;  P58675, ISPH_CLOPE;  
Q0STT3, ISPH_CLOPS;  Q895G2, ISPH_CLOTE;  Q486R1, ISPH_COLP3;  
Q6NI36, ISPH_CORDI;  Q8FQP0, ISPH_COREF;  A4QCY9, ISPH_CORGB;  
Q8NRM2, ISPH_CORGL;  B1WTZ2, ISPH_CROS5;  A7MIM0, ISPH_CROS8;  
Q6AA89, ISPH_CUTAK;  B8HWD3, ISPH_CYAP4;  Q11YY5, ISPH_CYTH3;  
Q47BK8, ISPH_DECAR;  Q3Z6U4, ISPH_DEHM1;  A5FPY7, ISPH_DEHMB;  
Q3ZYL6, ISPH_DEHMC;  Q9RSG0, ISPH_DEIRA;  Q316F5, ISPH_DESAG;  
B8J3G9, ISPH_DESDA;  C4XUD2, ISPH_DESMR;  Q6AL80, ISPH_DESPS;  
Q72G08, ISPH_DESVH;  B8DMK7, ISPH_DESVM;  A1VHK1, ISPH_DESVV;  
B5YEC2, ISPH_DICT6;  B8E2T7, ISPH_DICTD;  A8LLC7, ISPH_DINSH;  
A7ZHB8, ISPH_ECO24;  B7UI74, ISPH_ECO27;  B7MAE9, ISPH_ECO45;  
B7L4F1, ISPH_ECO55;  P62625, ISPH_ECO57;  B5YYC1, ISPH_ECO5E;  
B7NHD3, ISPH_ECO7I;  B7MNN4, ISPH_ECO81;  B7M0C5, ISPH_ECO8A;  
C4ZPV5, ISPH_ECOBW;  B1XBF4, ISPH_ECODH;  A7ZVX7, ISPH_ECOHS;  
A1A777, ISPH_ECOK1;  Q0TLW2, ISPH_ECOL5;  P62624, ISPH_ECOL6;  
B1IRE6, ISPH_ECOLC;  P62623, ISPH_ECOLI;  B7N7Q3, ISPH_ECOLU;  
B6HYX7, ISPH_ECOSE;  B1LFV9, ISPH_ECOSM;  Q1RGH3, ISPH_ECOUT;  
C5B7M7, ISPH_EDWI9;  Q5FFL5, ISPH_EHRRG;  Q5HB13, ISPH_EHRRW;  
A4W6E4, ISPH_ENT38;  B2VH04, ISPH_ERWT9;  B7LVN5, ISPH_ESCF3;  
B1YL84, ISPH_EXIS2;  C4L3Z5, ISPH_EXISA;  B0U064, ISPH_FRAP2;  
Q14I06, ISPH_FRAT1;  A7NA22, ISPH_FRATF;  Q2A587, ISPH_FRATH;  
B2SES8, ISPH_FRATM;  A0Q4T9, ISPH_FRATN;  Q0BNK1, ISPH_FRATO;  
Q5NGK4, ISPH_FRATT;  A4IYW2, ISPH_FRATW;  Q8RI52, ISPH_FUSNN;  
B9LZG4, ISPH_GEODF;  Q5KX24, ISPH_GEOKA;  B3E441, ISPH_GEOLS;  
Q39XB6, ISPH_GEOMG;  Q749Y8, ISPH_GEOSL;  C6E2B3, ISPH_GEOSM;  
C5D4R3, ISPH_GEOSW;  A4IR05, ISPH_GEOTN;  A5GE10, ISPH_GEOUR;  
B7KEG3, ISPH_GLOC7;  Q7NG74, ISPH_GLOVI;  Q5FUH7, ISPH_GLUOX;  
Q7VPK4, ISPH_HAEDU;  Q4QLQ5, ISPH_HAEI8;  A5UD69, ISPH_HAEIE;  
A5UID9, ISPH_HAEIG;  P44976, ISPH_HAEIN;  B8F6E6, ISPH_HAEPS;  
Q2S9U2, ISPH_HAHCH;  C4K4R2, ISPH_HAMD5;  Q7VJV5, ISPH_HELHP;  
B6JMP4, ISPH_HELP2;  Q1CSL3, ISPH_HELPH;  P65186, ISPH_HELPJ;  
B2UUG0, ISPH_HELPS;  P65185, ISPH_HELPY;  B0UV08, ISPH_HISS2;  
Q0BYQ0, ISPH_HYPNA;  Q5QZR7, ISPH_IDILO;  B5Y232, ISPH_KLEP3;  
A6T4G3, ISPH_KLEP7;  C5CIU9, ISPH_KOSOT;  Q6ADV0, ISPH_LEIXX;  
Q72S57, ISPH_LEPIC;  Q8F3I3, ISPH_LEPIN;  C1KV98, ISPH_LISMC;  
Q71ZL9, ISPH_LISMF;  P58676, ISPH_LISMO;  B1HTG5, ISPH_LYSSC;  
B9E6U8, ISPH_MACCJ;  A0LD71, ISPH_MAGMM;  Q65RQ4, ISPH_MANSM;  
A1TYZ2, ISPH_MARN8;  Q607E5, ISPH_METCA;  A2SJA8, ISPH_METPP;  
B8EQB9, ISPH_METSB;  B0JVA7, ISPH_MICAN;  A4T986, ISPH_MYCGI;  
Q9X781, ISPH_MYCLE;  Q73WH6, ISPH_MYCPA;  Q8EWR9, ISPH_MYCPE;  
A3Q4N0, ISPH_MYCSJ;  A1UKL5, ISPH_MYCSK;  Q1B4H4, ISPH_MYCSS;  
A0PKQ3, ISPH_MYCUA;  A1TE06, ISPH_MYCVP;  B9L9K5, ISPH_NAUPA;  
Q5FAF2, ISPH_NEIG1;  B4RPZ2, ISPH_NEIG2;  A9M1J9, ISPH_NEIM0;  
P65191, ISPH_NEIMA;  P65192, ISPH_NEIMB;  A1KS64, ISPH_NEIMF;  
Q2GDX3, ISPH_NEOSM;  Q82WM1, ISPH_NITEU;  A6Q2R7, ISPH_NITSB;  
Q5YQ94, ISPH_NOCFA;  B2IZV5, ISPH_NOSP7;  P58674, ISPH_NOSS1;  
B1ZXD4, ISPH_OPITP;  Q6AVG6, ISPH_ORYSJ;  A6LIB3, ISPH_PARD8;  
A1B842, ISPH_PARDP;  Q7U9K4, ISPH_PARMW;  Q6MC97, ISPH_PARUW;  
P57960, ISPH_PASMU;  Q6D0C6, ISPH_PECAS;  C6DF01, ISPH_PECCP;  
B4SCU0, ISPH_PELPB;  A1ANP9, ISPH_PELPD;  A9BGS3, ISPH_PETMO;  
B4R8T7, ISPH_PHEZH;  Q7N8W9, ISPH_PHOLL;  Q6LUK8, ISPH_PHOPR;  
A6L1P5, ISPH_PHOV8;  Q8I295, ISPH_PLAF7;  Q12EY5, ISPH_POLSJ;  
Q7MWK6, ISPH_PORGI;  B4S4X8, ISPH_PROA2;  A3PAY5, ISPH_PROM0;  
A2C096, ISPH_PROM1;  A2CCK3, ISPH_PROM3;  A9BDN6, ISPH_PROM4;  
A2BUP5, ISPH_PROM5;  Q31CR8, ISPH_PROM9;  Q7VDS2, ISPH_PROMA;  
B4F2T8, ISPH_PROMH;  Q7V4T7, ISPH_PROMM;  Q7V329, ISPH_PROMP;  
A2BP63, ISPH_PROMS;  Q46HB0, ISPH_PROMT;  Q48NK3, ISPH_PSE14;  
Q15R07, ISPH_PSEA6;  B7V0A0, ISPH_PSEA8;  Q02GC0, ISPH_PSEAB;  
Q9HVM7, ISPH_PSEAE;  Q1I4S8, ISPH_PSEE4;  Q4K5U7, ISPH_PSEF5;  
P21864, ISPH_PSEFL;  C3KDX7, ISPH_PSEFS;  A8F7S0, ISPH_PSELT;  
A4XQV8, ISPH_PSEMY;  A5VY55, ISPH_PSEP1;  Q3K6L8, ISPH_PSEPF;  
B0KM87, ISPH_PSEPG;  Q88Q89, ISPH_PSEPK;  B1JF80, ISPH_PSEPW;  
Q889E1, ISPH_PSESM;  Q3IE99, ISPH_PSET1;  Q4ZYJ1, ISPH_PSEU2;  
Q4FQY8, ISPH_PSYA2;  Q1Q974, ISPH_PSYCK;  A1SZP0, ISPH_PSYIN;  
A5WCZ2, ISPH_PSYWF;  P58677, ISPH_RALSO;  B3PSB9, ISPH_RHIE6;  
Q1MKH8, ISPH_RHIL3;  Q985W3, ISPH_RHILO;  B5ZSV9, ISPH_RHILW;  
Q92RG2, ISPH_RHIME;  Q7ULU1, ISPH_RHOBA;  C1A2V7, ISPH_RHOE4;  
Q0S489, ISPH_RHOJR;  C1AYI4, ISPH_RHOOB;  A3PGE9, ISPH_RHOS1;  
B7K4V8, ISPH_RIPO1;  Q16AJ6, ISPH_ROSDO;  Q5LNJ7, ISPH_RUEPO;  
Q1GDG5, ISPH_RUEST;  A1AXS1, ISPH_RUTMC;  Q21HK6, ISPH_SACD2;  
B5F728, ISPH_SALA4;  A9MR43, ISPH_SALAR;  Q57TL2, ISPH_SALCH;  
B5FHE3, ISPH_SALDC;  B5R1N9, ISPH_SALEP;  B5RG84, ISPH_SALG2;  
B4TIE9, ISPH_SALHS;  B4T6H5, ISPH_SALNS;  Q5PKI4, ISPH_SALPA;  
A9MYG8, ISPH_SALPB;  C0Q4I9, ISPH_SALPC;  B5BLL3, ISPH_SALPK;  
B4TWP0, ISPH_SALSV;  P58678, ISPH_SALTI;  P58679, ISPH_SALTY;  
A8G9L7, ISPH_SERP5;  B0TJB2, ISPH_SHEHH;  Q8EBI7, ISPH_SHEON;  
A8H1H6, ISPH_SHEPA;  B2U248, ISPH_SHIB3;  Q326J4, ISPH_SHIBS;  
Q32K68, ISPH_SHIDS;  Q0T8G5, ISPH_SHIF8;  Q7UDT8, ISPH_SHIFL;  
Q3Z5Y1, ISPH_SHISS;  Q2NVY3, ISPH_SODGM;  Q82IE8, ISPH_STRAW;  
Q9FBM1, ISPH_STRCO;  B1W2D7, ISPH_STRGG;  B4SP20, ISPH_STRM5;  
B2FU83, ISPH_STRMK;  Q30S81, ISPH_SULDN;  A6Q7P9, ISPH_SULNB;  
Q67QZ8, ISPH_SYMTH;  Q3A3D3, ISPH_SYNC1;  Q31S64, ISPH_SYNE7;  
B1XPG7, ISPH_SYNP2;  Q5N249, ISPH_SYNP6;  A5GIF7, ISPH_SYNPW;  
A5GWG3, ISPH_SYNR3;  Q0IDE5, ISPH_SYNS3;  Q3B080, ISPH_SYNS9;  
Q3AN10, ISPH_SYNSC;  Q55643, ISPH_SYNY3;  Q9X1F7, ISPH_THEMA;  
B9K8E2, ISPH_THENN;  A5IME1, ISPH_THEP1;  B0K9L0, ISPH_THEP3;  
B0K197, ISPH_THEPX;  B1LBI2, ISPH_THESQ;  Q72G65, ISPH_THET2;  
Q5SMC8, ISPH_THET8;  Q8DK29, ISPH_THEVB;  B8GQR4, ISPH_THISH;  
C4LD10, ISPH_TOLAT;  Q73NQ6, ISPH_TREDE;  O83558, ISPH_TREPA;  
B2S3D9, ISPH_TREPS;  Q10WA8, ISPH_TRIEI;  Q3M8X6, ISPH_TRIV2;  
Q83NB2, ISPH_TROW8;  Q83MR9, ISPH_TROWT;  A5CVK1, ISPH_VESOH;  
Q9KU44, ISPH_VIBCH;  Q87S87, ISPH_VIBPA;  Q8DET0, ISPH_VIBVU;  
Q7MNM5, ISPH_VIBVY;  Q8D2R2, ISPH_WIGBR;  Q73FQ1, ISPH_WOLPM;  
B3CM01, ISPH_WOLPP;  Q7M8Y6, ISPH_WOLSU;  Q5GTN6, ISPH_WOLTR;  
C0R4T5, ISPH_WOLWR;  Q8PN17, ISPH_XANAC;  Q3BW40, ISPH_XANC5;  
Q4US42, ISPH_XANC8;  B0RY26, ISPH_XANCB;  Q8PBG4, ISPH_XANCP;  
Q2P5A8, ISPH_XANOM;  B2STC6, ISPH_XANOP;  Q5H2D9, ISPH_XANOR;  
B2I6V0, ISPH_XYLF2;  P65193, ISPH_XYLFA;  B0U3Q7, ISPH_XYLFM;  
P65194, ISPH_XYLFT;  A1JJE4, ISPH_YERE8;  A7FMD4, ISPH_YERP3;  
Q1C0J0, ISPH_YERPA;  B2K3M9, ISPH_YERPB;  P58680, ISPH_YERPE;  
A9R005, ISPH_YERPG;  Q1CMU8, ISPH_YERPN;  A4TQF0, ISPH_YERPP;  
Q66ES1, ISPH_YERPS;  B1JKZ5, ISPH_YERPY;  Q5NP61, ISPH_ZYMMO;  

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