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ENZYME

ENZYME entry: EC 1.17.7.4

PURL: https://purl.expasy.org/enzyme/EC/1.17.7.4
Accepted Name
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Alternative Name(s)
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase
HMBPP reductase
Reaction catalysed
  • isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)
  • dimethylallyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)
Comment(s)
  • Forms a system with a ferredoxin or a flavodoxin and an NAD(P)H-dependent reductase.
  • This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis.
  • This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts.
  • The enzyme acts in the reverse direction, producing a 5:1 mixture of isopentenyl diphosphate and prenyl diphosphate.
  • Formerly EC 1.17.1.2.
Cross-references
BRENDA1.17.7.4
EC2PDB1.17.7.4
ExplorEnz1.17.7.4
KEGG Ligand Database for Enzyme Nomenclature1.17.7.4
IUBMB Enzyme Nomenclature1.17.7.4
MEDLINEFind literature relating to 1.17.7.4
MetaCyc1.17.7.4
Rhea expert-curated reactions1.17.7.4
UniProtKB/Swiss-Prot
A0A7J6F8C5, HDR_CANSAQ89UU5, ISPH1_BRADUQ629Z7, ISPH1_BURMA
Q63WH0, ISPH1_BURPSP0A5I1, ISPH1_MYCBOP9WKF8, ISPH1_MYCTO
P9WKF9, ISPH1_MYCTUQ6N3G0, ISPH1_RHOPAQ89QW7, ISPH2_BRADU
Q62HM8, ISPH2_BURMAP0DMK8, ISPH2_BURPSP0A5I3, ISPH2_MYCBO
P9WKG0, ISPH2_MYCTOP9WKG1, ISPH2_MYCTUQ6N1Y1, ISPH2_RHOPA
B0C4N8, ISPH_ACAM1Q9RBJ0, ISPH_ACIADB7GVR1, ISPH_ACIB3
B7IAU0, ISPH_ACIB5B2HZW3, ISPH_ACIBCB0VQ53, ISPH_ACIBS
A3M9H2, ISPH_ACIBTB0V8K4, ISPH_ACIBYA0LW20, ISPH_ACIC1
B7JBD6, ISPH_ACIF2B5ERJ7, ISPH_ACIF5A3N2G8, ISPH_ACTP2
B3GYK1, ISPH_ACTP7B0BRB3, ISPH_ACTPJA6VQH8, ISPH_ACTSZ
A0KG42, ISPH_AERHHA4SIX8, ISPH_AERS4P58673, ISPH_AGRFC
Q0VSD8, ISPH_ALCBSQ5E7N1, ISPH_ALIF1B5FA63, ISPH_ALIFM
B6ENC7, ISPH_ALISLA6TRF9, ISPH_ALKMQA8MFE2, ISPH_ALKOO
A7HCQ8, ISPH_ANADFB9KIX9, ISPH_ANAMFQ5PAE7, ISPH_ANAMM
B4UEK4, ISPH_ANASKB7GH78, ISPH_ANOFWO67625, ISPH_AQUAE
Q94B35, ISPH_ARATHQ5P224, ISPH_AROAEB6YQB8, ISPH_AZOPC
A1K4R4, ISPH_AZOSBC1DPH8, ISPH_AZOVDC3P8J4, ISPH_BACAA
C3LKW7, ISPH_BACACA0RIR1, ISPH_BACAHQ81LU9, ISPH_BACAN
B7JN13, ISPH_BACC0Q730P8, ISPH_BACC1B7IYD9, ISPH_BACC2
C1ESI2, ISPH_BACC3B7HCR2, ISPH_BACC4B7HPI8, ISPH_BACC7
A7GSY4, ISPH_BACCNB9IY56, ISPH_BACCQQ634Q0, ISPH_BACCZ
Q5L9K3, ISPH_BACFNQ64PU1, ISPH_BACFRQ6HDN0, ISPH_BACHK
Q65H97, ISPH_BACLDA9VHR7, ISPH_BACMKA8FFA1, ISPH_BACP2
P54473, ISPH_BACSUQ8A625, ISPH_BACTNA7Z6T1, ISPH_BACVZ
A1URX2, ISPH_BARBKQ6G4C5, ISPH_BARHEQ6G0C9, ISPH_BARQU
A9IQQ9, ISPH_BART1Q1LSS7, ISPH_BAUCHB2IED0, ISPH_BEII9
Q8G4L8, ISPH_BIFLOQ493S1, ISPH_BLOPBQ7WHF2, ISPH_BORBR
Q7W9B4, ISPH_BORPAQ7VYS2, ISPH_BORPEA0A2Z5WA18, ISPH_BOTBR
C0ZL73, ISPH_BREBNB2S9W9, ISPH_BRUA1A6WWG6, ISPH_BRUA4
Q57EP6, ISPH_BRUABQ8YFR1, ISPH_BRUMEQ8G257, ISPH_BRUSU
B8D8U8, ISPH_BUCA5P57247, ISPH_BUCAIQ8K9Z4, ISPH_BUCAP
B8D752, ISPH_BUCATI1WW99, ISPH_BURP2Q8RA76, ISPH_CALS4
A7ZCD0, ISPH_CAMC1A7GXB5, ISPH_CAMC5A0RQC4, ISPH_CAMFF
A7I0N0, ISPH_CAMHCA8FLU3, ISPH_CAMJ8A7H3F3, ISPH_CAMJD
P0C632, ISPH_CAMJEA1VZM8, ISPH_CAMJJQ5HUR4, ISPH_CAMJR
B9KD74, ISPH_CAMLRQ9A345, ISPH_CAUVCA3PGE9, ISPH_CERS1
Q3J5X0, ISPH_CERS4A4WVQ4, ISPH_CERS5Q11KC7, ISPH_CHESB
Q5L5D3, ISPH_CHLABQ3AT23, ISPH_CHLCHQ822D9, ISPH_CHLCV
Q255J4, ISPH_CHLFFB3EFF5, ISPH_CHLL2Q3B241, ISPH_CHLL3
Q9PL59, ISPH_CHLMUB3QQE0, ISPH_CHLP8B3EM42, ISPH_CHLPB
A1BDJ5, ISPH_CHLPDA4SGC0, ISPH_CHLPMQ9Z6P2, ISPH_CHLPN
B0B991, ISPH_CHLT2B3QSU2, ISPH_CHLT3Q3KKH8, ISPH_CHLTA
B0BAX0, ISPH_CHLTBQ8KFN9, ISPH_CHLTEO84867, ISPH_CHLTR
Q1R0B2, ISPH_CHRI1Q7NS59, ISPH_CHRVOB5E9S9, ISPH_CITBB
A8ALT3, ISPH_CITK8Q97I09, ISPH_CLOABQ187C6, ISPH_CLOD6
Q0TRF3, ISPH_CLOP1P58675, ISPH_CLOPEQ0STT3, ISPH_CLOPS
Q895G2, ISPH_CLOTEQ486R1, ISPH_COLP3Q6NI36, ISPH_CORDI
Q8FQP0, ISPH_COREFA4QCY9, ISPH_CORGBQ8NRM2, ISPH_CORGL
B1WTZ2, ISPH_CROS5A7MIM0, ISPH_CROS8Q6AA89, ISPH_CUTAK
B8HWD3, ISPH_CYAP4Q11YY5, ISPH_CYTH3Q47BK8, ISPH_DECAR
Q3Z6U4, ISPH_DEHM1A5FPY7, ISPH_DEHMBQ3ZYL6, ISPH_DEHMC
Q9RSG0, ISPH_DEIRAB8J3G9, ISPH_DESDAQ6AL80, ISPH_DESPS
B5YEC2, ISPH_DICT6B8E2T7, ISPH_DICTDA8LLC7, ISPH_DINSH
A7ZHB8, ISPH_ECO24B7UI74, ISPH_ECO27B7MAE9, ISPH_ECO45
B7L4F1, ISPH_ECO55P62625, ISPH_ECO57B5YYC1, ISPH_ECO5E
B7NHD3, ISPH_ECO7IB7MNN4, ISPH_ECO81B7M0C5, ISPH_ECO8A
C4ZPV5, ISPH_ECOBWB1XBF4, ISPH_ECODHA7ZVX7, ISPH_ECOHS
A1A777, ISPH_ECOK1Q0TLW2, ISPH_ECOL5P62624, ISPH_ECOL6
B1IRE6, ISPH_ECOLCP62623, ISPH_ECOLIB7N7Q3, ISPH_ECOLU
B6HYX7, ISPH_ECOSEB1LFV9, ISPH_ECOSMQ1RGH3, ISPH_ECOUT
A4XQV8, ISPH_ECTM1C5B7M7, ISPH_EDWI9Q5FFL5, ISPH_EHRRG
Q5HB13, ISPH_EHRRWQ2GDX3, ISPH_EHRS3A4W6E4, ISPH_ENT38
B2VH04, ISPH_ERWT9B7LVN5, ISPH_ESCF3B1YL84, ISPH_EXIS2
C4L3Z5, ISPH_EXISAB0U064, ISPH_FRAP2Q14I06, ISPH_FRAT1
A7NA22, ISPH_FRATFQ2A587, ISPH_FRATHB2SES8, ISPH_FRATM
A0Q4T9, ISPH_FRATNQ0BNK1, ISPH_FRATOQ5NGK4, ISPH_FRATT
A4IYW2, ISPH_FRATWQ8RI52, ISPH_FUSNNB9LZG4, ISPH_GEODF
Q5KX24, ISPH_GEOKAQ39XB6, ISPH_GEOMGQ749Y8, ISPH_GEOSL
C6E2B3, ISPH_GEOSMC5D4R3, ISPH_GEOSWA4IR05, ISPH_GEOTN
A5GE10, ISPH_GEOURB8F6E6, ISPH_GLAP5B7KEG3, ISPH_GLOC7
Q7NG74, ISPH_GLOVIQ5FUH7, ISPH_GLUOXQ7VPK4, ISPH_HAEDU
Q4QLQ5, ISPH_HAEI8A5UD69, ISPH_HAEIEA5UID9, ISPH_HAEIG
P44976, ISPH_HAEINQ2S9U2, ISPH_HAHCHQ9KD37, ISPH_HALH5
C4K4R2, ISPH_HAMD5Q7VJV5, ISPH_HELHPB6JMP4, ISPH_HELP2
Q1CSL3, ISPH_HELPHP65186, ISPH_HELPJB2UUG0, ISPH_HELPS
P65185, ISPH_HELPYB0UV08, ISPH_HISS2Q0BYQ0, ISPH_HYPNA
Q5QZR7, ISPH_IDILOA6T4G3, ISPH_KLEP7B5Y232, ISPH_KLEV3
C5CIU9, ISPH_KOSOTQ6ADV0, ISPH_LEIXXQ72S57, ISPH_LEPIC
Q8F3I3, ISPH_LEPINC1KV98, ISPH_LISMCQ71ZL9, ISPH_LISMF
P58676, ISPH_LISMOB1HTG5, ISPH_LYSSCB9E6U8, ISPH_MACCJ
A0LD71, ISPH_MAGMMQ8EWR9, ISPH_MALP2Q65RQ4, ISPH_MANSM
A1TYZ2, ISPH_MARN8Q607E5, ISPH_METCAA2SJA8, ISPH_METPP
B8EQB9, ISPH_METSBB0JVA7, ISPH_MICANA4T986, ISPH_MYCGI
Q9X781, ISPH_MYCLEQ73WH6, ISPH_MYCPAA3Q4N0, ISPH_MYCSJ
A1UKL5, ISPH_MYCSKQ1B4H4, ISPH_MYCSSA0PKQ3, ISPH_MYCUA
A1TE06, ISPH_MYCVPB9L9K5, ISPH_NAUPAQ5FAF2, ISPH_NEIG1
B4RPZ2, ISPH_NEIG2A9M1J9, ISPH_NEIM0P65191, ISPH_NEIMA
P65192, ISPH_NEIMBA1KS64, ISPH_NEIMFQ82WM1, ISPH_NITEU
A6Q2R7, ISPH_NITSBQ72G08, ISPH_NITV2A1VHK1, ISPH_NITV4
B8DMK7, ISPH_NITV9Q5YQ94, ISPH_NOCFAB2IZV5, ISPH_NOSP7
P58674, ISPH_NOSS1Q316F5, ISPH_OLEA2B1ZXD4, ISPH_OPITP
Q6AVG6, ISPH_ORYSJA6LIB3, ISPH_PARD8A1B842, ISPH_PARDP
Q7U9K4, ISPH_PARMWQ6MC97, ISPH_PARUWP57960, ISPH_PASMU
Q6D0C6, ISPH_PECASC6DF01, ISPH_PECCPB4SCU0, ISPH_PELPB
A1ANP9, ISPH_PELPDA9BGS3, ISPH_PETMOB4R8T7, ISPH_PHEZH
Q7N8W9, ISPH_PHOLLQ6LUK8, ISPH_PHOPRA6L1P5, ISPH_PHOV8
B1XPG7, ISPH_PICP2Q8I295, ISPH_PLAF7Q12EY5, ISPH_POLSJ
Q7MWK6, ISPH_PORGIB4S4X8, ISPH_PROA2A3PAY5, ISPH_PROM0
A2C096, ISPH_PROM1A2CCK3, ISPH_PROM3A9BDN6, ISPH_PROM4
A2BUP5, ISPH_PROM5Q31CR8, ISPH_PROM9Q7VDS2, ISPH_PROMA
B4F2T8, ISPH_PROMHQ7V4T7, ISPH_PROMMQ7V329, ISPH_PROMP
A2BP63, ISPH_PROMSQ46HB0, ISPH_PROMTQ48NK3, ISPH_PSE14
Q15R07, ISPH_PSEA6B7V0A0, ISPH_PSEA8Q02GC0, ISPH_PSEAB
Q9HVM7, ISPH_PSEAEQ1I4S8, ISPH_PSEE4Q4K5U7, ISPH_PSEF5
P21864, ISPH_PSEFLC3KDX7, ISPH_PSEFSA8F7S0, ISPH_PSELT
A5VY55, ISPH_PSEP1Q3K6L8, ISPH_PSEPFB0KM87, ISPH_PSEPG
Q88Q89, ISPH_PSEPKB1JF80, ISPH_PSEPWQ889E1, ISPH_PSESM
Q3IE99, ISPH_PSET1Q4ZYJ1, ISPH_PSEU2Q4FQY8, ISPH_PSYA2
Q1Q974, ISPH_PSYCKA1SZP0, ISPH_PSYINA5WCZ2, ISPH_PSYWF
P58677, ISPH_RALN1B3PSB9, ISPH_RHIE6Q1MKH8, ISPH_RHIJ3
Q985W3, ISPH_RHILOB5ZSV9, ISPH_RHILWQ92RG2, ISPH_RHIME
B9JAQ2, ISPH_RHIR8Q7ULU1, ISPH_RHOBAC1A2V7, ISPH_RHOE4
Q0S489, ISPH_RHOJRC1AYI4, ISPH_RHOOBB7K4V8, ISPH_RIPO1
Q16AJ6, ISPH_ROSDOQ5LNJ7, ISPH_RUEPOQ1GDG5, ISPH_RUEST
A1AXS1, ISPH_RUTMCQ21HK6, ISPH_SACD2B5F728, ISPH_SALA4
A9MR43, ISPH_SALARQ57TL2, ISPH_SALCHB5FHE3, ISPH_SALDC
B5R1N9, ISPH_SALEPB5RG84, ISPH_SALG2B4TIE9, ISPH_SALHS
B4T6H5, ISPH_SALNSQ5PKI4, ISPH_SALPAA9MYG8, ISPH_SALPB
C0Q4I9, ISPH_SALPCB5BLL3, ISPH_SALPKB4TWP0, ISPH_SALSV
P58678, ISPH_SALTIP58679, ISPH_SALTYA8G9L7, ISPH_SERP5
B0TJB2, ISPH_SHEHHQ8EBI7, ISPH_SHEONA8H1H6, ISPH_SHEPA
B2U248, ISPH_SHIB3Q326J4, ISPH_SHIBSQ32K68, ISPH_SHIDS
Q0T8G5, ISPH_SHIF8Q7UDT8, ISPH_SHIFLQ3Z5Y1, ISPH_SHISS
Q5WHC6, ISPH_SHOC1Q2NVY3, ISPH_SODGMC4XUD2, ISPH_SOLM1
Q82IE8, ISPH_STRAWQ9FBM1, ISPH_STRCOB1W2D7, ISPH_STRGG
B4SP20, ISPH_STRM5B2FU83, ISPH_STRMKQ30S81, ISPH_SULDN
A6Q7P9, ISPH_SULNBQ67QZ8, ISPH_SYMTHQ3A3D3, ISPH_SYNC1
Q31S64, ISPH_SYNE7Q5N249, ISPH_SYNP6A5GIF7, ISPH_SYNPW
A5GWG3, ISPH_SYNR3Q0IDE5, ISPH_SYNS3Q3B080, ISPH_SYNS9
Q3AN10, ISPH_SYNSCQ55643, ISPH_SYNY3Q9X1F7, ISPH_THEMA
B9K8E2, ISPH_THENNA5IME1, ISPH_THEP1B0K9L0, ISPH_THEP3
B0K197, ISPH_THEPXB1LBI2, ISPH_THESQQ72G65, ISPH_THET2
Q5SMC8, ISPH_THET8Q8DK29, ISPH_THEVBB8GQR4, ISPH_THISH
C4LD10, ISPH_TOLATQ73NQ6, ISPH_TREDEO83558, ISPH_TREPA
B2S3D9, ISPH_TREPSQ10WA8, ISPH_TRIEIB3E441, ISPH_TRIL1
Q3M8X6, ISPH_TRIV2Q83NB2, ISPH_TROW8Q83MR9, ISPH_TROWT
A5CVK1, ISPH_VESOHQ9KU44, ISPH_VIBCHQ87S87, ISPH_VIBPA
Q8DET0, ISPH_VIBVUQ7MNM5, ISPH_VIBVYQ8D2R2, ISPH_WIGBR
Q73FQ1, ISPH_WOLPMB3CM01, ISPH_WOLPPQ7M8Y6, ISPH_WOLSU
Q5GTN6, ISPH_WOLTRC0R4T5, ISPH_WOLWRQ8PN17, ISPH_XANAC
Q4US42, ISPH_XANC8B0RY26, ISPH_XANCBQ8PBG4, ISPH_XANCP
Q3BW40, ISPH_XANE5Q2P5A8, ISPH_XANOMB2STC6, ISPH_XANOP
Q5H2D9, ISPH_XANORB2I6V0, ISPH_XYLF2P65193, ISPH_XYLFA
B0U3Q7, ISPH_XYLFMP65194, ISPH_XYLFTA1JJE4, ISPH_YERE8
A7FMD4, ISPH_YERP3Q1C0J0, ISPH_YERPAB2K3M9, ISPH_YERPB
P58680, ISPH_YERPEA9R005, ISPH_YERPGQ1CMU8, ISPH_YERPN
A4TQF0, ISPH_YERPPQ66ES1, ISPH_YERPSB1JKZ5, ISPH_YERPY
Q5NP61, ISPH_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-