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ENZYME

ENZYME entry: EC 1.17.7.4

Accepted Name
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Alternative Name(s)
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase
HMBPP reductase
Reaction catalysed
  • H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
  • dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
Comment(s)
  • Forms a system with a ferredoxin or a flavodoxin and an NAD(P)H-dependent reductase.
  • This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis.
  • This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts.
  • The enzyme acts in the reverse direction, producing a 5:1 mixture of isopentenyl diphosphate and prenyl diphosphate.
  • Formerly EC 1.17.1.2.
Cross-references
BRENDA1.17.7.4
EC2PDB1.17.7.4
ExplorEnz1.17.7.4
PRIAM enzyme-specific profiles1.17.7.4
KEGG Ligand Database for Enzyme Nomenclature1.17.7.4
IUBMB Enzyme Nomenclature1.17.7.4
IntEnz1.17.7.4
MEDLINEFind literature relating to 1.17.7.4
MetaCyc1.17.7.4
Rhea expert-curated reactions1.17.7.4
UniProtKB/Swiss-Prot
Q89UU5, ISPH1_BRADUQ629Z7, ISPH1_BURMAQ63WH0, ISPH1_BURPS
P0A5I1, ISPH1_MYCBOP9WKF8, ISPH1_MYCTOP9WKF9, ISPH1_MYCTU
Q6N3G0, ISPH1_RHOPAQ89QW7, ISPH2_BRADUQ62HM8, ISPH2_BURMA
P0DMK8, ISPH2_BURPSP0A5I3, ISPH2_MYCBOP9WKG0, ISPH2_MYCTO
P9WKG1, ISPH2_MYCTUQ6N1Y1, ISPH2_RHOPAB0C4N8, ISPH_ACAM1
Q9RBJ0, ISPH_ACIADB7GVR1, ISPH_ACIB3B7IAU0, ISPH_ACIB5
B2HZW3, ISPH_ACIBCB0VQ53, ISPH_ACIBSA3M9H2, ISPH_ACIBT
B0V8K4, ISPH_ACIBYA0LW20, ISPH_ACIC1B7JBD6, ISPH_ACIF2
B5ERJ7, ISPH_ACIF5A3N2G8, ISPH_ACTP2B3GYK1, ISPH_ACTP7
B0BRB3, ISPH_ACTPJA6VQH8, ISPH_ACTSZA0KG42, ISPH_AERHH
A4SIX8, ISPH_AERS4P58673, ISPH_AGRFCQ0VSD8, ISPH_ALCBS
Q5E7N1, ISPH_ALIF1B5FA63, ISPH_ALIFMB6ENC7, ISPH_ALISL
A6TRF9, ISPH_ALKMQA8MFE2, ISPH_ALKOOA7HCQ8, ISPH_ANADF
B9KIX9, ISPH_ANAMFQ5PAE7, ISPH_ANAMMB4UEK4, ISPH_ANASK
B7GH78, ISPH_ANOFWO67625, ISPH_AQUAEQ94B35, ISPH_ARATH
Q5P224, ISPH_AROAEB6YQB8, ISPH_AZOPCA1K4R4, ISPH_AZOSB
C1DPH8, ISPH_AZOVDC3P8J4, ISPH_BACAAC3LKW7, ISPH_BACAC
A0RIR1, ISPH_BACAHQ81LU9, ISPH_BACANB7JN13, ISPH_BACC0
Q730P8, ISPH_BACC1B7IYD9, ISPH_BACC2C1ESI2, ISPH_BACC3
B7HCR2, ISPH_BACC4B7HPI8, ISPH_BACC7A7GSY4, ISPH_BACCN
B9IY56, ISPH_BACCQQ634Q0, ISPH_BACCZQ5L9K3, ISPH_BACFN
Q64PU1, ISPH_BACFRQ6HDN0, ISPH_BACHKQ65H97, ISPH_BACLD
A9VHR7, ISPH_BACMKA8FFA1, ISPH_BACP2P54473, ISPH_BACSU
Q8A625, ISPH_BACTNA7Z6T1, ISPH_BACVZA1URX2, ISPH_BARBK
Q6G4C5, ISPH_BARHEQ6G0C9, ISPH_BARQUA9IQQ9, ISPH_BART1
Q1LSS7, ISPH_BAUCHB2IED0, ISPH_BEII9Q8G4L8, ISPH_BIFLO
Q493S1, ISPH_BLOPBQ7WHF2, ISPH_BORBRQ7W9B4, ISPH_BORPA
Q7VYS2, ISPH_BORPEA0A2Z5WA18, ISPH_BOTBRC0ZL73, ISPH_BREBN
B2S9W9, ISPH_BRUA1A6WWG6, ISPH_BRUA4Q57EP6, ISPH_BRUAB
Q8YFR1, ISPH_BRUMEQ8G257, ISPH_BRUSUB8D8U8, ISPH_BUCA5
P57247, ISPH_BUCAIQ8K9Z4, ISPH_BUCAPB8D752, ISPH_BUCAT
I1WW99, ISPH_BURP2Q8RA76, ISPH_CALS4A7ZCD0, ISPH_CAMC1
A7GXB5, ISPH_CAMC5A0RQC4, ISPH_CAMFFA7I0N0, ISPH_CAMHC
A8FLU3, ISPH_CAMJ8A7H3F3, ISPH_CAMJDP0C632, ISPH_CAMJE
A1VZM8, ISPH_CAMJJQ5HUR4, ISPH_CAMJRB9KD74, ISPH_CAMLR
Q9A345, ISPH_CAUVCA3PGE9, ISPH_CERS1Q3J5X0, ISPH_CERS4
A4WVQ4, ISPH_CERS5Q11KC7, ISPH_CHESBQ5L5D3, ISPH_CHLAB
Q3AT23, ISPH_CHLCHQ822D9, ISPH_CHLCVQ255J4, ISPH_CHLFF
B3EFF5, ISPH_CHLL2Q3B241, ISPH_CHLL3Q9PL59, ISPH_CHLMU
B3QQE0, ISPH_CHLP8B3EM42, ISPH_CHLPBA1BDJ5, ISPH_CHLPD
A4SGC0, ISPH_CHLPMQ9Z6P2, ISPH_CHLPNB0B991, ISPH_CHLT2
B3QSU2, ISPH_CHLT3Q3KKH8, ISPH_CHLTAB0BAX0, ISPH_CHLTB
Q8KFN9, ISPH_CHLTEO84867, ISPH_CHLTRQ1R0B2, ISPH_CHRSD
Q7NS59, ISPH_CHRVOB5E9S9, ISPH_CITBBA8ALT3, ISPH_CITK8
Q97I09, ISPH_CLOABQ187C6, ISPH_CLOD6Q0TRF3, ISPH_CLOP1
P58675, ISPH_CLOPEQ0STT3, ISPH_CLOPSQ895G2, ISPH_CLOTE
Q486R1, ISPH_COLP3Q6NI36, ISPH_CORDIQ8FQP0, ISPH_COREF
A4QCY9, ISPH_CORGBQ8NRM2, ISPH_CORGLB1WTZ2, ISPH_CROS5
A7MIM0, ISPH_CROS8Q6AA89, ISPH_CUTAKB8HWD3, ISPH_CYAP4
Q11YY5, ISPH_CYTH3Q47BK8, ISPH_DECARQ3Z6U4, ISPH_DEHM1
A5FPY7, ISPH_DEHMBQ3ZYL6, ISPH_DEHMCQ9RSG0, ISPH_DEIRA
B8J3G9, ISPH_DESDAQ6AL80, ISPH_DESPSB5YEC2, ISPH_DICT6
B8E2T7, ISPH_DICTDA8LLC7, ISPH_DINSHA7ZHB8, ISPH_ECO24
B7UI74, ISPH_ECO27B7MAE9, ISPH_ECO45B7L4F1, ISPH_ECO55
P62625, ISPH_ECO57B5YYC1, ISPH_ECO5EB7NHD3, ISPH_ECO7I
B7MNN4, ISPH_ECO81B7M0C5, ISPH_ECO8AC4ZPV5, ISPH_ECOBW
B1XBF4, ISPH_ECODHA7ZVX7, ISPH_ECOHSA1A777, ISPH_ECOK1
Q0TLW2, ISPH_ECOL5P62624, ISPH_ECOL6B1IRE6, ISPH_ECOLC
P62623, ISPH_ECOLIB7N7Q3, ISPH_ECOLUB6HYX7, ISPH_ECOSE
B1LFV9, ISPH_ECOSMQ1RGH3, ISPH_ECOUTC5B7M7, ISPH_EDWI9
Q5FFL5, ISPH_EHRRGQ5HB13, ISPH_EHRRWA4W6E4, ISPH_ENT38
B2VH04, ISPH_ERWT9B7LVN5, ISPH_ESCF3B1YL84, ISPH_EXIS2
C4L3Z5, ISPH_EXISAB0U064, ISPH_FRAP2Q14I06, ISPH_FRAT1
A7NA22, ISPH_FRATFQ2A587, ISPH_FRATHB2SES8, ISPH_FRATM
A0Q4T9, ISPH_FRATNQ0BNK1, ISPH_FRATOQ5NGK4, ISPH_FRATT
A4IYW2, ISPH_FRATWQ8RI52, ISPH_FUSNNB9LZG4, ISPH_GEODF
Q5KX24, ISPH_GEOKAQ39XB6, ISPH_GEOMGQ749Y8, ISPH_GEOSL
C6E2B3, ISPH_GEOSMC5D4R3, ISPH_GEOSWA4IR05, ISPH_GEOTN
A5GE10, ISPH_GEOURB8F6E6, ISPH_GLAP5B7KEG3, ISPH_GLOC7
Q7NG74, ISPH_GLOVIQ5FUH7, ISPH_GLUOXQ7VPK4, ISPH_HAEDU
Q4QLQ5, ISPH_HAEI8A5UD69, ISPH_HAEIEA5UID9, ISPH_HAEIG
P44976, ISPH_HAEINQ2S9U2, ISPH_HAHCHQ9KD37, ISPH_HALH5
C4K4R2, ISPH_HAMD5Q7VJV5, ISPH_HELHPB6JMP4, ISPH_HELP2
Q1CSL3, ISPH_HELPHP65186, ISPH_HELPJB2UUG0, ISPH_HELPS
P65185, ISPH_HELPYB0UV08, ISPH_HISS2Q0BYQ0, ISPH_HYPNA
Q5QZR7, ISPH_IDILOB5Y232, ISPH_KLEP3A6T4G3, ISPH_KLEP7
C5CIU9, ISPH_KOSOTQ6ADV0, ISPH_LEIXXQ72S57, ISPH_LEPIC
Q8F3I3, ISPH_LEPINC1KV98, ISPH_LISMCQ71ZL9, ISPH_LISMF
P58676, ISPH_LISMOB1HTG5, ISPH_LYSSCB9E6U8, ISPH_MACCJ
A0LD71, ISPH_MAGMMQ8EWR9, ISPH_MALP2Q65RQ4, ISPH_MANSM
A1TYZ2, ISPH_MARN8Q607E5, ISPH_METCAA2SJA8, ISPH_METPP
B8EQB9, ISPH_METSBB0JVA7, ISPH_MICANA4T986, ISPH_MYCGI
Q9X781, ISPH_MYCLEQ73WH6, ISPH_MYCPAA3Q4N0, ISPH_MYCSJ
A1UKL5, ISPH_MYCSKQ1B4H4, ISPH_MYCSSA0PKQ3, ISPH_MYCUA
A1TE06, ISPH_MYCVPB9L9K5, ISPH_NAUPAQ5FAF2, ISPH_NEIG1
B4RPZ2, ISPH_NEIG2A9M1J9, ISPH_NEIM0P65191, ISPH_NEIMA
P65192, ISPH_NEIMBA1KS64, ISPH_NEIMFQ2GDX3, ISPH_NEOSM
Q82WM1, ISPH_NITEUA6Q2R7, ISPH_NITSBQ72G08, ISPH_NITV2
A1VHK1, ISPH_NITV4B8DMK7, ISPH_NITV9Q5YQ94, ISPH_NOCFA
B2IZV5, ISPH_NOSP7P58674, ISPH_NOSS1Q316F5, ISPH_OLEA2
B1ZXD4, ISPH_OPITPQ6AVG6, ISPH_ORYSJA6LIB3, ISPH_PARD8
A1B842, ISPH_PARDPQ7U9K4, ISPH_PARMWQ6MC97, ISPH_PARUW
P57960, ISPH_PASMUQ6D0C6, ISPH_PECASC6DF01, ISPH_PECCP
B4SCU0, ISPH_PELPBA1ANP9, ISPH_PELPDA9BGS3, ISPH_PETMO
B4R8T7, ISPH_PHEZHQ7N8W9, ISPH_PHOLLQ6LUK8, ISPH_PHOPR
A6L1P5, ISPH_PHOV8B1XPG7, ISPH_PICP2Q8I295, ISPH_PLAF7
Q12EY5, ISPH_POLSJQ7MWK6, ISPH_PORGIB4S4X8, ISPH_PROA2
A3PAY5, ISPH_PROM0A2C096, ISPH_PROM1A2CCK3, ISPH_PROM3
A9BDN6, ISPH_PROM4A2BUP5, ISPH_PROM5Q31CR8, ISPH_PROM9
Q7VDS2, ISPH_PROMAB4F2T8, ISPH_PROMHQ7V4T7, ISPH_PROMM
Q7V329, ISPH_PROMPA2BP63, ISPH_PROMSQ46HB0, ISPH_PROMT
Q48NK3, ISPH_PSE14Q15R07, ISPH_PSEA6B7V0A0, ISPH_PSEA8
Q02GC0, ISPH_PSEABQ9HVM7, ISPH_PSEAEQ1I4S8, ISPH_PSEE4
Q4K5U7, ISPH_PSEF5P21864, ISPH_PSEFLC3KDX7, ISPH_PSEFS
A8F7S0, ISPH_PSELTA4XQV8, ISPH_PSEMYA5VY55, ISPH_PSEP1
Q3K6L8, ISPH_PSEPFB0KM87, ISPH_PSEPGQ88Q89, ISPH_PSEPK
B1JF80, ISPH_PSEPWQ889E1, ISPH_PSESMQ3IE99, ISPH_PSET1
Q4ZYJ1, ISPH_PSEU2Q4FQY8, ISPH_PSYA2Q1Q974, ISPH_PSYCK
A1SZP0, ISPH_PSYINA5WCZ2, ISPH_PSYWFP58677, ISPH_RALN1
B3PSB9, ISPH_RHIE6Q1MKH8, ISPH_RHIJ3Q985W3, ISPH_RHILO
B5ZSV9, ISPH_RHILWQ92RG2, ISPH_RHIMEB9JAQ2, ISPH_RHIR8
Q7ULU1, ISPH_RHOBAC1A2V7, ISPH_RHOE4Q0S489, ISPH_RHOJR
C1AYI4, ISPH_RHOOBB7K4V8, ISPH_RIPO1Q16AJ6, ISPH_ROSDO
Q5LNJ7, ISPH_RUEPOQ1GDG5, ISPH_RUESTA1AXS1, ISPH_RUTMC
Q21HK6, ISPH_SACD2B5F728, ISPH_SALA4A9MR43, ISPH_SALAR
Q57TL2, ISPH_SALCHB5FHE3, ISPH_SALDCB5R1N9, ISPH_SALEP
B5RG84, ISPH_SALG2B4TIE9, ISPH_SALHSB4T6H5, ISPH_SALNS
Q5PKI4, ISPH_SALPAA9MYG8, ISPH_SALPBC0Q4I9, ISPH_SALPC
B5BLL3, ISPH_SALPKB4TWP0, ISPH_SALSVP58678, ISPH_SALTI
P58679, ISPH_SALTYA8G9L7, ISPH_SERP5B0TJB2, ISPH_SHEHH
Q8EBI7, ISPH_SHEONA8H1H6, ISPH_SHEPAB2U248, ISPH_SHIB3
Q326J4, ISPH_SHIBSQ32K68, ISPH_SHIDSQ0T8G5, ISPH_SHIF8
Q7UDT8, ISPH_SHIFLQ3Z5Y1, ISPH_SHISSQ5WHC6, ISPH_SHOC1
Q2NVY3, ISPH_SODGMC4XUD2, ISPH_SOLM1Q82IE8, ISPH_STRAW
Q9FBM1, ISPH_STRCOB1W2D7, ISPH_STRGGB4SP20, ISPH_STRM5
B2FU83, ISPH_STRMKQ30S81, ISPH_SULDNA6Q7P9, ISPH_SULNB
Q67QZ8, ISPH_SYMTHQ3A3D3, ISPH_SYNC1Q31S64, ISPH_SYNE7
Q5N249, ISPH_SYNP6A5GIF7, ISPH_SYNPWA5GWG3, ISPH_SYNR3
Q0IDE5, ISPH_SYNS3Q3B080, ISPH_SYNS9Q3AN10, ISPH_SYNSC
Q55643, ISPH_SYNY3Q9X1F7, ISPH_THEMAB9K8E2, ISPH_THENN
A5IME1, ISPH_THEP1B0K9L0, ISPH_THEP3B0K197, ISPH_THEPX
B1LBI2, ISPH_THESQQ72G65, ISPH_THET2Q5SMC8, ISPH_THET8
Q8DK29, ISPH_THEVBB8GQR4, ISPH_THISHC4LD10, ISPH_TOLAT
Q73NQ6, ISPH_TREDEO83558, ISPH_TREPAB2S3D9, ISPH_TREPS
Q10WA8, ISPH_TRIEIB3E441, ISPH_TRIL1Q3M8X6, ISPH_TRIV2
Q83NB2, ISPH_TROW8Q83MR9, ISPH_TROWTA5CVK1, ISPH_VESOH
Q9KU44, ISPH_VIBCHQ87S87, ISPH_VIBPAQ8DET0, ISPH_VIBVU
Q7MNM5, ISPH_VIBVYQ8D2R2, ISPH_WIGBRQ73FQ1, ISPH_WOLPM
B3CM01, ISPH_WOLPPQ7M8Y6, ISPH_WOLSUQ5GTN6, ISPH_WOLTR
C0R4T5, ISPH_WOLWRQ8PN17, ISPH_XANACQ4US42, ISPH_XANC8
B0RY26, ISPH_XANCBQ8PBG4, ISPH_XANCPQ3BW40, ISPH_XANE5
Q2P5A8, ISPH_XANOMB2STC6, ISPH_XANOPQ5H2D9, ISPH_XANOR
B2I6V0, ISPH_XYLF2P65193, ISPH_XYLFAB0U3Q7, ISPH_XYLFM
P65194, ISPH_XYLFTA1JJE4, ISPH_YERE8A7FMD4, ISPH_YERP3
Q1C0J0, ISPH_YERPAB2K3M9, ISPH_YERPBP58680, ISPH_YERPE
A9R005, ISPH_YERPGQ1CMU8, ISPH_YERPNA4TQF0, ISPH_YERPP
Q66ES1, ISPH_YERPSB1JKZ5, ISPH_YERPYQ5NP61, ISPH_ZYMMO

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-