Expasy logo

ENZYME

ENZYME entry: EC 1.17.7.4

Accepted Name
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Alternative Name(s)
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase
HMBPP reductase
Reaction catalysed
  • H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
  • dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
Comment(s)
  • Forms a system with a ferredoxin or a flavodoxin and an NAD(P)H-dependent reductase.
  • This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis.
  • This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts.
  • The enzyme acts in the reverse direction, producing a 5:1 mixture of isopentenyl diphosphate and prenyl diphosphate.
  • Formerly EC 1.17.1.2.
Cross-references
BRENDA1.17.7.4
EC2PDB1.17.7.4
ExplorEnz1.17.7.4
PRIAM enzyme-specific profiles1.17.7.4
KEGG Ligand Database for Enzyme Nomenclature1.17.7.4
IUBMB Enzyme Nomenclature1.17.7.4
IntEnz1.17.7.4
MEDLINEFind literature relating to 1.17.7.4
MetaCyc1.17.7.4
Rhea expert-curated reactions1.17.7.4
UniProtKB/Swiss-Prot
Q89UU5, ISPH1_BRADUQ629Z7, ISPH1_BURMAQ63WH0, ISPH1_BURPS
P0A5I1, ISPH1_MYCBOP9WKF8, ISPH1_MYCTOP9WKF9, ISPH1_MYCTU
Q6N3G0, ISPH1_RHOPAQ89QW7, ISPH2_BRADUQ62HM8, ISPH2_BURMA
P0DMK8, ISPH2_BURPSP0A5I3, ISPH2_MYCBOP9WKG0, ISPH2_MYCTO
P9WKG1, ISPH2_MYCTUQ6N1Y1, ISPH2_RHOPAB0C4N8, ISPH_ACAM1
Q9RBJ0, ISPH_ACIADB7GVR1, ISPH_ACIB3B7IAU0, ISPH_ACIB5
B2HZW3, ISPH_ACIBCB0VQ53, ISPH_ACIBSA3M9H2, ISPH_ACIBT
B0V8K4, ISPH_ACIBYA0LW20, ISPH_ACIC1B7JBD6, ISPH_ACIF2
B5ERJ7, ISPH_ACIF5A3N2G8, ISPH_ACTP2B3GYK1, ISPH_ACTP7
B0BRB3, ISPH_ACTPJA6VQH8, ISPH_ACTSZA0KG42, ISPH_AERHH
A4SIX8, ISPH_AERS4P58673, ISPH_AGRFCB9JAQ2, ISPH_AGRRK
Q0VSD8, ISPH_ALCBSQ5E7N1, ISPH_ALIF1B5FA63, ISPH_ALIFM
B6ENC7, ISPH_ALISLQ5WHC6, ISPH_ALKCKA6TRF9, ISPH_ALKMQ
A8MFE2, ISPH_ALKOOA7HCQ8, ISPH_ANADFB9KIX9, ISPH_ANAMF
Q5PAE7, ISPH_ANAMMB4UEK4, ISPH_ANASKB7GH78, ISPH_ANOFW
O67625, ISPH_AQUAEQ94B35, ISPH_ARATHQ5P224, ISPH_AROAE
B6YQB8, ISPH_AZOPCA1K4R4, ISPH_AZOSBC1DPH8, ISPH_AZOVD
C3P8J4, ISPH_BACAAC3LKW7, ISPH_BACACA0RIR1, ISPH_BACAH
Q81LU9, ISPH_BACANB7JN13, ISPH_BACC0Q730P8, ISPH_BACC1
B7IYD9, ISPH_BACC2C1ESI2, ISPH_BACC3B7HCR2, ISPH_BACC4
B7HPI8, ISPH_BACC7A7GSY4, ISPH_BACCNB9IY56, ISPH_BACCQ
Q634Q0, ISPH_BACCZQ5L9K3, ISPH_BACFNQ64PU1, ISPH_BACFR
Q6HDN0, ISPH_BACHKQ65H97, ISPH_BACLDA9VHR7, ISPH_BACMK
A8FFA1, ISPH_BACP2P54473, ISPH_BACSUQ8A625, ISPH_BACTN
A7Z6T1, ISPH_BACVZA1URX2, ISPH_BARBKQ6G4C5, ISPH_BARHE
Q6G0C9, ISPH_BARQUA9IQQ9, ISPH_BART1Q1LSS7, ISPH_BAUCH
B2IED0, ISPH_BEII9Q8G4L8, ISPH_BIFLOQ493S1, ISPH_BLOPB
Q7WHF2, ISPH_BORBRQ7W9B4, ISPH_BORPAQ7VYS2, ISPH_BORPE
A0A2Z5WA18, ISPH_BOTBRC0ZL73, ISPH_BREBNB2S9W9, ISPH_BRUA1
A6WWG6, ISPH_BRUA4Q57EP6, ISPH_BRUABQ8YFR1, ISPH_BRUME
Q8G257, ISPH_BRUSUB8D8U8, ISPH_BUCA5P57247, ISPH_BUCAI
Q8K9Z4, ISPH_BUCAPB8D752, ISPH_BUCATI1WW99, ISPH_BURP2
Q8RA76, ISPH_CALS4A7ZCD0, ISPH_CAMC1A7GXB5, ISPH_CAMC5
A0RQC4, ISPH_CAMFFA7I0N0, ISPH_CAMHCA8FLU3, ISPH_CAMJ8
A7H3F3, ISPH_CAMJDP0C632, ISPH_CAMJEA1VZM8, ISPH_CAMJJ
Q5HUR4, ISPH_CAMJRB9KD74, ISPH_CAMLRQ9A345, ISPH_CAUVC
A3PGE9, ISPH_CERS1Q3J5X0, ISPH_CERS4A4WVQ4, ISPH_CERS5
Q11KC7, ISPH_CHESBQ5L5D3, ISPH_CHLABQ3AT23, ISPH_CHLCH
Q822D9, ISPH_CHLCVQ255J4, ISPH_CHLFFB3EFF5, ISPH_CHLL2
Q3B241, ISPH_CHLL3Q9PL59, ISPH_CHLMUB3QQE0, ISPH_CHLP8
B3EM42, ISPH_CHLPBA1BDJ5, ISPH_CHLPDA4SGC0, ISPH_CHLPM
Q9Z6P2, ISPH_CHLPNB0B991, ISPH_CHLT2B3QSU2, ISPH_CHLT3
Q3KKH8, ISPH_CHLTAB0BAX0, ISPH_CHLTBQ8KFN9, ISPH_CHLTE
O84867, ISPH_CHLTRQ1R0B2, ISPH_CHRSDQ7NS59, ISPH_CHRVO
B5E9S9, ISPH_CITBBA8ALT3, ISPH_CITK8Q97I09, ISPH_CLOAB
Q187C6, ISPH_CLOD6Q0TRF3, ISPH_CLOP1P58675, ISPH_CLOPE
Q0STT3, ISPH_CLOPSQ895G2, ISPH_CLOTEQ486R1, ISPH_COLP3
Q6NI36, ISPH_CORDIQ8FQP0, ISPH_COREFA4QCY9, ISPH_CORGB
Q8NRM2, ISPH_CORGLB1WTZ2, ISPH_CROS5A7MIM0, ISPH_CROS8
Q6AA89, ISPH_CUTAKB8HWD3, ISPH_CYAP4Q11YY5, ISPH_CYTH3
Q47BK8, ISPH_DECARQ3Z6U4, ISPH_DEHM1A5FPY7, ISPH_DEHMB
Q3ZYL6, ISPH_DEHMCQ9RSG0, ISPH_DEIRAB8J3G9, ISPH_DESDA
Q6AL80, ISPH_DESPSQ72G08, ISPH_DESVHB8DMK7, ISPH_DESVM
A1VHK1, ISPH_DESVVB5YEC2, ISPH_DICT6B8E2T7, ISPH_DICTD
A8LLC7, ISPH_DINSHA7ZHB8, ISPH_ECO24B7UI74, ISPH_ECO27
B7MAE9, ISPH_ECO45B7L4F1, ISPH_ECO55P62625, ISPH_ECO57
B5YYC1, ISPH_ECO5EB7NHD3, ISPH_ECO7IB7MNN4, ISPH_ECO81
B7M0C5, ISPH_ECO8AC4ZPV5, ISPH_ECOBWB1XBF4, ISPH_ECODH
A7ZVX7, ISPH_ECOHSA1A777, ISPH_ECOK1Q0TLW2, ISPH_ECOL5
P62624, ISPH_ECOL6B1IRE6, ISPH_ECOLCP62623, ISPH_ECOLI
B7N7Q3, ISPH_ECOLUB6HYX7, ISPH_ECOSEB1LFV9, ISPH_ECOSM
Q1RGH3, ISPH_ECOUTC5B7M7, ISPH_EDWI9Q5FFL5, ISPH_EHRRG
Q5HB13, ISPH_EHRRWA4W6E4, ISPH_ENT38B2VH04, ISPH_ERWT9
B7LVN5, ISPH_ESCF3B1YL84, ISPH_EXIS2C4L3Z5, ISPH_EXISA
B0U064, ISPH_FRAP2Q14I06, ISPH_FRAT1A7NA22, ISPH_FRATF
Q2A587, ISPH_FRATHB2SES8, ISPH_FRATMA0Q4T9, ISPH_FRATN
Q0BNK1, ISPH_FRATOQ5NGK4, ISPH_FRATTA4IYW2, ISPH_FRATW
Q8RI52, ISPH_FUSNNB9LZG4, ISPH_GEODFQ5KX24, ISPH_GEOKA
Q39XB6, ISPH_GEOMGQ749Y8, ISPH_GEOSLC6E2B3, ISPH_GEOSM
C5D4R3, ISPH_GEOSWA4IR05, ISPH_GEOTNA5GE10, ISPH_GEOUR
B8F6E6, ISPH_GLAP5B7KEG3, ISPH_GLOC7Q7NG74, ISPH_GLOVI
Q5FUH7, ISPH_GLUOXQ7VPK4, ISPH_HAEDUQ4QLQ5, ISPH_HAEI8
A5UD69, ISPH_HAEIEA5UID9, ISPH_HAEIGP44976, ISPH_HAEIN
Q2S9U2, ISPH_HAHCHQ9KD37, ISPH_HALH5C4K4R2, ISPH_HAMD5
Q7VJV5, ISPH_HELHPB6JMP4, ISPH_HELP2Q1CSL3, ISPH_HELPH
P65186, ISPH_HELPJB2UUG0, ISPH_HELPSP65185, ISPH_HELPY
B0UV08, ISPH_HISS2Q0BYQ0, ISPH_HYPNAQ5QZR7, ISPH_IDILO
B5Y232, ISPH_KLEP3A6T4G3, ISPH_KLEP7C5CIU9, ISPH_KOSOT
Q6ADV0, ISPH_LEIXXQ72S57, ISPH_LEPICQ8F3I3, ISPH_LEPIN
C1KV98, ISPH_LISMCQ71ZL9, ISPH_LISMFP58676, ISPH_LISMO
B1HTG5, ISPH_LYSSCB9E6U8, ISPH_MACCJA0LD71, ISPH_MAGMM
Q8EWR9, ISPH_MALP2Q65RQ4, ISPH_MANSMA1TYZ2, ISPH_MARN8
Q607E5, ISPH_METCAA2SJA8, ISPH_METPPB8EQB9, ISPH_METSB
B0JVA7, ISPH_MICANA4T986, ISPH_MYCGIQ9X781, ISPH_MYCLE
Q73WH6, ISPH_MYCPAA3Q4N0, ISPH_MYCSJA1UKL5, ISPH_MYCSK
Q1B4H4, ISPH_MYCSSA0PKQ3, ISPH_MYCUAA1TE06, ISPH_MYCVP
B9L9K5, ISPH_NAUPAQ5FAF2, ISPH_NEIG1B4RPZ2, ISPH_NEIG2
A9M1J9, ISPH_NEIM0P65191, ISPH_NEIMAP65192, ISPH_NEIMB
A1KS64, ISPH_NEIMFQ2GDX3, ISPH_NEOSMQ82WM1, ISPH_NITEU
A6Q2R7, ISPH_NITSBQ5YQ94, ISPH_NOCFAB2IZV5, ISPH_NOSP7
P58674, ISPH_NOSS1Q316F5, ISPH_OLEA2B1ZXD4, ISPH_OPITP
Q6AVG6, ISPH_ORYSJA6LIB3, ISPH_PARD8A1B842, ISPH_PARDP
Q7U9K4, ISPH_PARMWQ6MC97, ISPH_PARUWP57960, ISPH_PASMU
Q6D0C6, ISPH_PECASC6DF01, ISPH_PECCPB4SCU0, ISPH_PELPB
A1ANP9, ISPH_PELPDA9BGS3, ISPH_PETMOB4R8T7, ISPH_PHEZH
Q7N8W9, ISPH_PHOLLQ6LUK8, ISPH_PHOPRA6L1P5, ISPH_PHOV8
Q8I295, ISPH_PLAF7Q12EY5, ISPH_POLSJQ7MWK6, ISPH_PORGI
B4S4X8, ISPH_PROA2A3PAY5, ISPH_PROM0A2C096, ISPH_PROM1
A2CCK3, ISPH_PROM3A9BDN6, ISPH_PROM4A2BUP5, ISPH_PROM5
Q31CR8, ISPH_PROM9Q7VDS2, ISPH_PROMAB4F2T8, ISPH_PROMH
Q7V4T7, ISPH_PROMMQ7V329, ISPH_PROMPA2BP63, ISPH_PROMS
Q46HB0, ISPH_PROMTQ48NK3, ISPH_PSE14Q15R07, ISPH_PSEA6
B7V0A0, ISPH_PSEA8Q02GC0, ISPH_PSEABQ9HVM7, ISPH_PSEAE
Q1I4S8, ISPH_PSEE4Q4K5U7, ISPH_PSEF5P21864, ISPH_PSEFL
C3KDX7, ISPH_PSEFSA8F7S0, ISPH_PSELTA4XQV8, ISPH_PSEMY
A5VY55, ISPH_PSEP1Q3K6L8, ISPH_PSEPFB0KM87, ISPH_PSEPG
Q88Q89, ISPH_PSEPKB1JF80, ISPH_PSEPWQ889E1, ISPH_PSESM
Q3IE99, ISPH_PSET1Q4ZYJ1, ISPH_PSEU2Q4FQY8, ISPH_PSYA2
Q1Q974, ISPH_PSYCKA1SZP0, ISPH_PSYINA5WCZ2, ISPH_PSYWF
P58677, ISPH_RALN1B3PSB9, ISPH_RHIE6Q1MKH8, ISPH_RHIL3
Q985W3, ISPH_RHILOB5ZSV9, ISPH_RHILWQ92RG2, ISPH_RHIME
Q7ULU1, ISPH_RHOBAC1A2V7, ISPH_RHOE4Q0S489, ISPH_RHOJR
C1AYI4, ISPH_RHOOBB7K4V8, ISPH_RIPO1Q16AJ6, ISPH_ROSDO
Q5LNJ7, ISPH_RUEPOQ1GDG5, ISPH_RUESTA1AXS1, ISPH_RUTMC
Q21HK6, ISPH_SACD2B5F728, ISPH_SALA4A9MR43, ISPH_SALAR
Q57TL2, ISPH_SALCHB5FHE3, ISPH_SALDCB5R1N9, ISPH_SALEP
B5RG84, ISPH_SALG2B4TIE9, ISPH_SALHSB4T6H5, ISPH_SALNS
Q5PKI4, ISPH_SALPAA9MYG8, ISPH_SALPBC0Q4I9, ISPH_SALPC
B5BLL3, ISPH_SALPKB4TWP0, ISPH_SALSVP58678, ISPH_SALTI
P58679, ISPH_SALTYA8G9L7, ISPH_SERP5B0TJB2, ISPH_SHEHH
Q8EBI7, ISPH_SHEONA8H1H6, ISPH_SHEPAB2U248, ISPH_SHIB3
Q326J4, ISPH_SHIBSQ32K68, ISPH_SHIDSQ0T8G5, ISPH_SHIF8
Q7UDT8, ISPH_SHIFLQ3Z5Y1, ISPH_SHISSQ2NVY3, ISPH_SODGM
C4XUD2, ISPH_SOLM1Q82IE8, ISPH_STRAWQ9FBM1, ISPH_STRCO
B1W2D7, ISPH_STRGGB4SP20, ISPH_STRM5B2FU83, ISPH_STRMK
Q30S81, ISPH_SULDNA6Q7P9, ISPH_SULNBQ67QZ8, ISPH_SYMTH
Q3A3D3, ISPH_SYNC1Q31S64, ISPH_SYNE7B1XPG7, ISPH_SYNP2
Q5N249, ISPH_SYNP6A5GIF7, ISPH_SYNPWA5GWG3, ISPH_SYNR3
Q0IDE5, ISPH_SYNS3Q3B080, ISPH_SYNS9Q3AN10, ISPH_SYNSC
Q55643, ISPH_SYNY3Q9X1F7, ISPH_THEMAB9K8E2, ISPH_THENN
A5IME1, ISPH_THEP1B0K9L0, ISPH_THEP3B0K197, ISPH_THEPX
B1LBI2, ISPH_THESQQ72G65, ISPH_THET2Q5SMC8, ISPH_THET8
Q8DK29, ISPH_THEVBB8GQR4, ISPH_THISHC4LD10, ISPH_TOLAT
Q73NQ6, ISPH_TREDEO83558, ISPH_TREPAB2S3D9, ISPH_TREPS
Q10WA8, ISPH_TRIEIB3E441, ISPH_TRIL1Q3M8X6, ISPH_TRIV2
Q83NB2, ISPH_TROW8Q83MR9, ISPH_TROWTA5CVK1, ISPH_VESOH
Q9KU44, ISPH_VIBCHQ87S87, ISPH_VIBPAQ8DET0, ISPH_VIBVU
Q7MNM5, ISPH_VIBVYQ8D2R2, ISPH_WIGBRQ73FQ1, ISPH_WOLPM
B3CM01, ISPH_WOLPPQ7M8Y6, ISPH_WOLSUQ5GTN6, ISPH_WOLTR
C0R4T5, ISPH_WOLWRQ8PN17, ISPH_XANACQ3BW40, ISPH_XANC5
Q4US42, ISPH_XANC8B0RY26, ISPH_XANCBQ8PBG4, ISPH_XANCP
Q2P5A8, ISPH_XANOMB2STC6, ISPH_XANOPQ5H2D9, ISPH_XANOR
B2I6V0, ISPH_XYLF2P65193, ISPH_XYLFAB0U3Q7, ISPH_XYLFM
P65194, ISPH_XYLFTA1JJE4, ISPH_YERE8A7FMD4, ISPH_YERP3
Q1C0J0, ISPH_YERPAB2K3M9, ISPH_YERPBP58680, ISPH_YERPE
A9R005, ISPH_YERPGQ1CMU8, ISPH_YERPNA4TQF0, ISPH_YERPP
Q66ES1, ISPH_YERPSB1JKZ5, ISPH_YERPYQ5NP61, ISPH_ZYMMO

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-