ENZYME entry: EC 1.17.8.1

Accepted Name
Hydroxysqualene dehydroxylase.
Reaction catalysed
Squalene + FAD + H(2)O <=> hydroxysqualene + FADH(2)
Comment(s)
  • This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103 and EC 4.2.3.156, in the conversion of all-trans-farnesyl diphosphate to squalene.
  • Eukaryotes achieve the same goal in a single step, catalyzed by EC 2.5.1.21.
Cross-references
BRENDA1.17.8.1
EC2PDB1.17.8.1
ExplorEnz1.17.8.1
PRIAM enzyme-specific profiles1.17.8.1
KEGG Ligand Database for Enzyme Nomenclature1.17.8.1
IUBMB Enzyme Nomenclature1.17.8.1
IntEnz1.17.8.1
MEDLINEFind literature relating to 1.17.8.1
MetaCyc1.17.8.1
UniProtKB/Swiss-Prot
Q6N3F3, HPNE_RHOPA;  P55349, HPNE_SINFN;  Q5NP65, HPNE_ZYMMO;  

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