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ENZYME entry: EC 4.2.3.156

Accepted Name
hydroxysqualene synthase.
Reaction catalysed
H2O + presqualene diphosphate <=> diphosphate + hydroxysqualene
Comment(s)
  • This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103 and EC 1.17.18.1, in the conversion of all-trans-farnesyl diphosphate to squalene.
  • Eukaryotes achieve the same goal in a single step, catalyzed by EC 2.5.1.21.
Cross-references
BRENDA4.2.3.156
EC2PDB4.2.3.156
ExplorEnz4.2.3.156
PRIAM enzyme-specific profiles4.2.3.156
KEGG Ligand Database for Enzyme Nomenclature4.2.3.156
IUBMB Enzyme Nomenclature4.2.3.156
IntEnz4.2.3.156
MEDLINEFind literature relating to 4.2.3.156
MetaCyc4.2.3.156
Rhea expert-curated reactions4.2.3.156
UniProtKB/Swiss-Prot
Q6N3F1, HPNC_RHOPA;  P55351, HPNC_SINFN;  Q5NP67, HPNC_ZYMMO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-